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Compositions and methods for treatment for neoplasms

A composition and tumor technology, applied in the identification of compositions, the field of compositions for treating or preventing tumors such as cancer, can solve problems such as poor prognosis of primary brain tumors

Inactive Publication Date: 2008-07-09
COMBINATORX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Primary brain tumors have an extremely poor prognosis despite vigorous treatment with existing therapies

Method used

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  • Compositions and methods for treatment for neoplasms
  • Compositions and methods for treatment for neoplasms
  • Compositions and methods for treatment for neoplasms

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0214] Antiproliferative Agent Screening Assays

[0215] experimental method

[0216] Approved small molecule drugs selected from drug libraries were screened in combination for their antiproliferative activity against the D54MG glioblastoma multiforme (GBM) cell line. Cell titer - blue pigment (Promega) was used to measure the metabolic potential of D54MG cells and can be used as an indirect measure of the number of surviving cells in the well. Cell Titer - The blue pigment is a non-fluorescent pigment that is reduced by living cells to a red fluorescent product that can be easily quantified.

[0217] tumor cell culture

[0218] At 37±0.5°C and 5% CO 2 The human D54MG cell line was cultured in Roswell Park Memorial Institute (RPMI)-1640 medium supplemented with 10% fetal bovine serum (FBS), 2mM glutamine, 1% penicillin and 1% streptomycin (provided by Dr. Courtesy Darrell Bigner, Duke Univeristy).

[0219] test compound

[0220] Irinotecan hydrochloride was obtained fro...

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PUM

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Abstract

The present invention is characterized by: a composition comprising two, three or more drugs for treating tumor patients; a method for treating tumors such as cancer (for example, brain cancer); comprising two, three or more drugs kits of drugs for the treatment of cancer; and methods for the identification of combinations of compounds that may be useful in the treatment of cancer patients.

Description

Background of the invention [0001] The present invention relates to: pharmaceutical combinations and methods for treating tumors, such as cancer (eg, brain cancer); kits comprising pharmaceutical compositions and pharmaceutical combinations for treating tumors; and methods for identifying combinations of compounds for treating tumors. [0002] Cancer is a disease characterized by the uncontrolled growth of abnormal cells. Cancer cells grow unrestrictedly overcoming obstacles imparted to normal cells, which have a finite lifespan. As cancer cells continue to grow, genetic alterations can persist until the cancer cells manifest themselves in pursuit of a more aggressive growth phenotype. If left untreated, metastasis can ensue, in which cancer cells spread through the lymph system or bloodstream to distant areas of the body, destroying healthy tissue. Brain tumors are the leading cause of death from childhood cancer and the second most common cause of cancer-related death in m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/47
CPCA61K31/48A61K31/675A61K31/366A61K31/7048A61K31/4745A61K31/44A61K45/06A61K31/522A61P35/00A61P35/02A61P43/00A61K2300/00A61K31/47
Inventor L·M·约翰森M·S·李M·J·尼科尓斯G·R·齐默曼
Owner COMBINATORX
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