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Naphthenic acid, 1,10-phenanthroline rare earth complex, preparation method and antimycotic application thereof

A technology of rare earth complexes and o-phenanthroline, applied in botany equipment and methods, antifungal agents, chemicals for biological control, etc., can solve the problems of antifungal properties that need further research, and achieve remarkable results. The effect of simple synthesis method

Inactive Publication Date: 2008-08-06
HEBEI NORMAL UNIV
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Problems solved by technology

The research results disclosed in the prior art mainly focus on the inhibitory effect of simple rare earth inorganic or organic salts on bacteria. Although they have strong antibacterial properties and a wide antibacterial spectrum, the acidity of the solution is strong, which has a double effect on the growth of fungi. effect, its antifungal properties need further study

Method used

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  • Naphthenic acid, 1,10-phenanthroline rare earth complex, preparation method and antimycotic application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The synthesis of embodiment 1 rare earth complex

[0027] The structural formula of the rare earth complex provided by the present invention is: RE L 3 phen nH 2 O;

[0028] Where RE: can be Eu in rare earth elements 3+ , Tb 3+ 、Gd 3+ , La 3+ , Y 3+ Any one of; n=0 or 1;

[0029] L is the first ligand: α-Naphthoic acid, β-Naphthoic acid, α-Naphthlcetic acid, β-Naphthlcetic acid can be used as one of the four naphthoic acids. The Chinese names of the four naphthoic acids are α-naphthoic acid, β - naphthoic acid, alpha-naphthylacetic acid, beta-naphthylacetic acid;

[0030] Phen is the second ligand: Phen is the abbreviation of 1,10-phenanthroline (1,10-phenanthroline), and its chemical formula is C 12 h 8 N 2 ; There are 19 complexes in total, and the composition and chemical formula of the rare earth complexes are listed in the following table:

[0031] Table 1: Composition and chemical formula list of the synthesized rare earth complexes

[0032] ...

Embodiment 2

[0039] Embodiment 2 ligand, DMF (N, N-dimethylformamide), rare earth ion, the comparison of rare earth complex bacteriostasis

[0040] Using DMF as a solvent, prepare 0.012mol / L of 1,10-phenanthroline, four kinds of naphthoic acids, Eucl 3 , Tbcl 3 , Gdcl 3 、Lacl 3 、Ycl 3 and Eu(α-NMA) 3 phen H 2 O, Tb(α-NMA) 3 phen H 2 O, Gd(α-NMA) 3 phen H 2 O, La(α-NMA) 3 phen, Y(α-NMA) 3 phen, Eu(β-NMA) 3 phen, Tb(β-NMA) 3 phen, Gd(β-NMA) 3 phen, Y(β-NMA) 3 phen, Eu(α-NAA) 3 phen, Tb(α-NAA) 3 phen, Gd(α-NAA) 3 phen, La(α-NAA) 3 phen, Y(α-NAA) 3 phen, Eu(β-NAA) 3 phen, Tb(β-NAA) 3 phen, Gd(β-NAA) 3 phen H 2 O, La(β-NAA) 3 phen, Y(β-NAA) 3 phen solution. The effects of ligand, DMF, rare earth ions and complexes on yeast growth were compared by filter paper method (d=0.6cm).

[0041] Prepare YPD (Yeast Peptone Dextrose medium, English name Yeast Peptone Dextrose) medium, 1000mL (20g of peptone and 10g of yeast powder) will be dissolved to 950mL, adjusted to pH=6.5, ...

Embodiment 3

[0044] The mensuration that embodiment 3 medicine concentration affects yeast growth

[0045] Adopt filter paper method (d=0.6cm) to carry out quantitative antibacterial experiment: prepare various complexes of concentration gradient (0.004mol / L, 0.008mol / L, 0.01mol / L, 0.012mol / L), will have the same kind Filter paper sheets with different concentrations of drugs were pasted on the same plate to observe the effect of drug concentration on fungal growth.

[0046] The preparation of culture medium is identical with example 2. Select the preserved strain of yeast and activate it for 3 to 4 times to obtain bacteria with better activity. The activated bacteria were inoculated in the liquid medium, and cultured at 180 rpm at 30°C for 18 hours (about 10 9 pieces / ml). Take YPD Yeast Peptone Dextrose Agar medium (Yeast Peptone Dextrose Agar) to melt and cool to 48-50°C, add 500 μl of bacterial solution per 20ml and shake quickly, pour the plate, stick filter paper on the plate, each...

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Abstract

The invention discloses a naphthoic acid and 1, 10-o-phenanthroline rare-earth complex and relative function for inhibiting yeast, which is represented as REL3phen nH2O, wherein RE is rare-earth element as Eu3+, Tb3+, Gd3+, La3+ or Y3+, L is one of alpha-Naphthoic acid, beta-Naphthoic acid, alpha-Naphthlcetic acid and beta-Naphthlcetic acid, n=0 or 1. The preparation method comprises using L as first ligand and o-phenanthroline as second ligand while RE3+: L: phen is 1:3:1, adding alcohol and dissolving, mixing the two ligands to be added into a rare-earth chloride solution, mixing and reacting to synthesize rare-earth complex. The bacteriostatic test of filter paper method on fungus proves that the rare-earth complex has significant inhibition on yeast stronger than pure ion and complex, with concentration dosage effect. The invention provides useful reference for microbe bacteria inhibitor development.

Description

technical field [0001] The invention relates to a rare earth complex, in particular to a rare earth complex with naphthoic acid and 1,10-phenanthroline as ligands, and belongs to the technical field of microbial antibacterial. Background technique [0002] Rare earths, my country's reserve resources account for about 80% of the world, rare earths have a unique electronic layer and nuclear structure, and have good antibacterial, anti-inflammatory, anti-tumor effects. Since the 20th century, research on rare earths in the field of life sciences has been continuously reported. Due to its low toxicity, its antibacterial properties have good application prospects in agriculture, medical and health. For example, cerium nitrate has been used clinically as a bactericidal and anti-inflammatory agent due to its good therapeutic effect on burns. Rare earth can improve the disease resistance of crops by inhibiting the growth and reproduction of pathogenic bacteria. With the increasin...

Claims

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Application Information

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IPC IPC(8): C07F5/00A01N55/02A61K31/555A01P1/00A61P31/10
Inventor 赵宝华王瑞芬杨楠赵娜马亚娟刘金玲
Owner HEBEI NORMAL UNIV
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