Skin enrichment using CoQ10 as the delivery system

A skin, composition technology, applied in the field of dermatological preparations, which can solve the problem of reduced efficacy

Inactive Publication Date: 2008-10-15
ZYMES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, at certain points in a person's life, the synthetic site of CoQ10 begins to be less effective (Blizakov et al., supra)

Method used

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  • Skin enrichment using CoQ10 as the delivery system
  • Skin enrichment using CoQ10 as the delivery system
  • Skin enrichment using CoQ10 as the delivery system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

acne medication

[0062] In one embodiment, the present invention provides a composition comprising a compound according to general formula (I) for use in the treatment of acne and improvement of skin health. In one embodiment, adapalene is present as the active ingredient in the formulation in the range of about 0.01% to about 5% per gram. In some embodiments, adapalene is present at a concentration of about 0.1% / gram to form a topical gel delivery system.

[0063] Adapalene is effective in treating existing acne lesions and preventing their development or further proliferation. This drug can be used indefinitely with minimal side effects. Adapalene is a chemically stable retinoid-like analog containing a carboxylic acid residue. Unfortunately, it is only slightly soluble in polar solvents such as ethanol and practically insoluble in water. For adapalene to be effective, it must be absorbed through epithelial cells which have multiple layers. Due to its natural chemical str...

Embodiment 1

[0115] The following formulations represent some typical anti-acne formulations according to the invention. When these formulations are applied topically to the skin, the symptoms of acne are improved.

Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4

[0116] In one embodiment, the topical composition comprises azelaic acid, as described below. In one embodiment, the formulation is a cream. Typically, the cream may contain:

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Abstract

The present invention provides several skin enrichment formulations comprising ubiquinones. The present invention provides a composition for the treatment of acne, topical antimicrobial ointment, sunscreening agents, facial cleansing, reduction of skin inflammation, firming skin tone, cosmetic foundation, skin protection, lip skin protection and skin cream. In a preferred embodiment, the composition contains Coenzyme Q10.

Description

Skin concentrate using CoQ10 as delivery system Cross references to related applications The application requires the U.S. provisional application 60 / 668,273 submitted on April 5th, 2005 and the priority of the U.S. provisional application 60 / 667,380 submitted on April 1st, 2005, their content is incorporated by reference for all purposes This article. Background of the invention [0002] Ubiquinone, also commonly referred to as coenzyme Qn (n=1-12), constitutes a major cellular component of many biological forms. In humans, CoQ10 is the major constituent of this type of polyprenoidal natural product, known to function primarily as a redox carrier in the respiratory chain, and it is the form most studied as a potential therapeutic agent (Lenaz ,COENZYMEQ.BIOCHEMISTRY,BiOENERGETiCS,AND CLINICALAPPLICATIONSOFUBIQUINONE,Wiley-Interscience:New York(1985);Trumpower,FUNCTIONOFUBIQUINONESINENERGY CONSERVINGSYSTEMS,AcademicPress,NewYork(1982);Thomson, R.H.,NATURALLYOCCURRINGQUINONE...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/075A61K31/205A61K31/355A61K31/20A61K31/34A61K31/07
Inventor B・H・利普舒茨D・多尔尼克
Owner ZYMES
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