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Aniline quinazoline derivatives, preparation method and uses thereof

A technology of aniline quinazoline and its derivatives, which is applied in the fields of medicinal chemistry and pharmacotherapeutics, can solve the problem of increased toxicity, and achieve the effects of low toxicity, easy transport, and good water solubility

Inactive Publication Date: 2008-10-22
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Drugs that are completely insoluble in water are not easy to show biological activity, and the toxicity will become greater

Method used

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  • Aniline quinazoline derivatives, preparation method and uses thereof
  • Aniline quinazoline derivatives, preparation method and uses thereof
  • Aniline quinazoline derivatives, preparation method and uses thereof

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Abstract

The invention relates to the field of medical chemistry and pharmacotherapeutics, specifically, the invention relates to an aniline quinazoline derivative, the preparation method and the use thereof shown in the following general formula I. The side chain of the aniline quinazoline derivative provided by the invention comprises various pyrrolidine rings; compared with Iressa, the derivative has stronger cytotoxic activity to tumor cell lines and is a promising antitumor medicine.

Description

Aniline quinazoline derivatives, their preparation and use technical field The present invention relates to the field of medicinal chemistry and pharmacotherapeutics, in particular, the present invention relates to an aniline quinazoline derivative, its preparation method and its use. Background technique Tumor is a disease that seriously endangers health. Among various diseases, the mortality rate of malignant tumors ranks second, second only to cardiovascular and cerebrovascular diseases. Since the 1970s, the incidence of malignant tumors has been increasing at an annual rate of 3% to 5%. According to statistics, more than 6 million patients die of malignant tumors all over the world every year, and nearly 6 million people develop tumors every year. Therefore, searching for highly effective, low-toxic, and cheap anticancer drugs has become a research hotspot for medical workers worldwide. Protein tyrosine kinase (PTK) plays an important role in the process of cell sig...

Claims

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Application Information

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IPC IPC(8): C07D403/12A61K31/506A61P35/00
Inventor 段文虎赵翠花蒋华良丁健陈晓蓓谢华
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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