Patch and patch preparation

A technology of patch and cross-linking agent, applied in the field of patch and patch preparation, can solve the problem that the patch cannot fully meet the application, and achieve the effects of excellent cohesion, less residue and less skin irritation

Inactive Publication Date: 2009-01-07
NITTO DENKO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This indicates that the patch of this example cannot adequately satisfy the application aspect

Method used

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  • Patch and patch preparation
  • Patch and patch preparation

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

experiment example 1

[0060]

[0062] It can be clearly seen from Table 1 that in Example 1, skin irritation, adhesiveness, residue and cohesion, which represent practical properties, are all excellent or within a tolerable range.

[0063]In addition, in Examples 2, 3, and 4, in which the BR of Example 1 was replaced by IR, IIR, and SIS, respectively, skin irritation, adhesiveness, residue, and cohesion of practical properties were exhibited, all of which were excellent or within the tolerable range. In particular, Example 4 using SIS is most preferred because the properties are well balanced.

[0064] In addition, Example 5 (in which LIR3 of Example 2 was replaced with LIR2 (trifunctional liquid rubber component)) exhibited excellent results such as improved cohesion and the like. This indicates that the liquid rubber component preferably has at least 3 functional groups in its molecule.

Embodiment A

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Abstract

The present invention aims to provide a patch and a patch preparation that do not require an acrylic polymer, and are capable of maintaining a large amount of an organic liquid component in an adhesive layer. The present invention provides a patch containing a support and an adhesive layer provided on at least one surface of the support, wherein the adhesive layer contains a synthetic rubber component other than polyisobutylene and solid at 25 DEG C, a liquid rubber component having a crosslinkable functional group in a molecule, and an organic liquid component, the adhesive layer is crosslinked, and the liquid rubber component is contained in a proportion of less than 30 wt% relative to the total weight of the synthetic rubber component solid at 25 DEG C and the liquid rubber component.

Description

technical field [0001] The present invention relates to a patch and a patch preparation. Background technique [0002] Conventionally developed patches include an adhesive layer formed on one surface of a support. This adhesive layer is required to positively secure the patch to the skin surface. However, when the adhesive force of the skin is too high, the skin may be irritated during detachment of the patch from the skin. As a means of reducing such skin irritation, the adhesive component may contain an organic liquid component. In addition, when the adhesive layer is a drug-containing patch preparation, the adhesive component may contain an organic liquid component to control the release ability of the drug from the adhesive layer or to stabilize the drug in the adhesive layer. [0003] For this purpose, an adhesive layer in which an acrylic polymer is crosslinked to hold an organic liquid component is suggested. However, chemical ingredients such as certain drugs ten...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32
CPCA61L31/041A61K9/7053Y10T428/2883C08L21/00A61K9/70A61K47/30
Inventor 滨田昌志笠原刚石仓准船桥美纪
Owner NITTO DENKO CORP
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