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Quality control detection method of Xuefu Zhuyu oral liquid

A blood stasis removal, control detection technology, applied in the direction of blood diseases, medical preparations containing active ingredients, liquid delivery, etc., can solve the problems that cannot guarantee the detection of drugs, to achieve stability and uniformity, comprehensive quality control, Good precision and reproducibility

Active Publication Date: 2009-02-11
JILIN AODONG YANBIAN PHARM CO LTD
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Problems solved by technology

[0003] The original testing standard of "Xuefu Zhuyu Oral Liquid" is recorded in the thirteenth volume of the new drug standard of the Ministry of Health of the People's Republic of China. The original standard only contains medicinal materials For the TLC identification of Fructus Fructus Fructus and Radix Paeoniae Rubra and the detection content of Radix Radix Radix Radix Radix Paeoniae Rubra by HPLC, since there are few detection methods in the original standard, a comprehensive detection of the drug cannot be guaranteed

Method used

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  • Quality control detection method of Xuefu Zhuyu oral liquid
  • Quality control detection method of Xuefu Zhuyu oral liquid
  • Quality control detection method of Xuefu Zhuyu oral liquid

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Embodiment 1

[0030] 1) Take 10ml of Xuefuzhuyu Oral Liquid, put it in a separatory funnel, shake and extract 2 times with water-saturated n-butanol, 10ml each time, combine the n-butanol solution, wash with water twice, and evaporate the n-butanol layer to dryness. Add 1ml of methanol to the residue to dissolve it as the test solution. Take another hesperidin reference substance, add methanol to make a solution containing 1mg per 1ml, and use it as the reference substance solution; according to the thin-layer chromatography test, draw 2μl of each of the above two solutions, and point them on the same spot and prepare them with 1% sodium hydroxide. Use ethyl acetate-methanol-water (100:17:13) as the developer on a thin-layer silica gel G thin-layer plate, develop with a distance of 3 cm, take it out, dry it, and then develop it with toluene-ethyl acetate-formic acid-water ( 20:10:1:1) the upper layer solution is the developing agent, unfolding, the spreading distance is 8cm, take out, dry, ...

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Abstract

The invention discloses a quality control and test method of an oral solution for activating blood circulation and resolving blood stagnation, which is a thin-layer chromatography test method for detecting achyranthes and liquorice in the prescription of the oral solution for activating blood circulation and resolving blood stagnation on the basis of an original detection standard. The detection method improves the thin-layer chromatography method of fructus aurantii and increases the determining content of the high-performance and liquid-phase chromatography method of angelica and rhizoma Ligustici Wallichi in the prescription. The method provided by the invention is advanced, has good precision and repeatability, is used for controlling the quality of the medicament of the oral solution for activating blood circulation and resolving blood stagnation, can control the quality of the oral solution overall and guarantee stable and homogeneous product quality.

Description

technical field [0001] The invention discloses a quality control detection method for Xuefu Zhuyu Oral Liquid, which belongs to the technical field of pharmaceutical detection methods. Background technique [0002] The "Xuefu Zhuyu Oral Liquid" involved in the present invention is prepared by the following process: 180g of Angelica sinensis, 90g of Chuanxiong, 60g of Bupleurum, 120g of Radix Paeoniae Rubra, and 120g of Citrus aurantii, and add 6 times the amount of water and steam distillation Distilled for 8 hours to extract the volatile oil, the volatile oil is used for later use; the dregs, 240g of peach kernel, 180g of safflower, 180g of rehmannia glutinosa, 180g of Achyranthes bidentata, 90g of platycodon grandiflorum, 60g of licorice and other six flavors are decocted in water three times, and the amount of water added is 6 times the amount of medicinal materials for the first time. 6 times the amount of medicinal materials for the second time, 5 times the amount of me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/75A61K9/10G01N30/90G01N30/02A61P29/00A61P25/20A61P7/00
Inventor 郭淑芹解钧秀于江波许加胜王永彬李伟
Owner JILIN AODONG YANBIAN PHARM CO LTD
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