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Improved simulated moving bed chromatographic fractionation system

A technology for simulating moving bed and chromatographic separation, applied in separation methods, ion exchange, ion exchange regeneration, etc., can solve problems such as not being able to reduce system pressure, and achieve the effect of improving operating pressure and stability

Inactive Publication Date: 2009-04-08
NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, although the simulated moving bed with open-loop structure reduces the amount of stationary phase, it cannot reduce the system pressure.

Method used

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  • Improved simulated moving bed chromatographic fractionation system
  • Improved simulated moving bed chromatographic fractionation system
  • Improved simulated moving bed chromatographic fractionation system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The simulated moving bed experimental device is Pilot System C916 (Germany Knauer), and carry out such as figure 2 Modification shown: omit zone I, and arrange 2 hypersil C18 columns (10cm×1.0cm, Dalian Yilite) in each zone II-III. The eluent is directly pumped into zone II; the raw material is pumped into the separation system from between zone II and zone III; the raffinate is collected from the outlet of zone III; the extract is collected from the outlet of zone IV. The positions of the four material ports move to the next column outlet along the direction of the mobile phase at regular intervals. The flow rate and switching time of each zone are listed in Table 1. Among the zones II~IV, the pressure in zone III is the highest, which is 3.5Mpa.

Embodiment 2

[0023] The simulated moving bed experimental device is Pilot System C916 (Germany Knauer), and carry out such as image 3 Modification shown: omit zone I, and arrange 2 hypersil C18 columns (10cm×1.0cm, Dalian Yilite) in each zone II-III. Rinse zone II directly with eluent and collect extract from zone IV outlet. Zone II is disconnected from Zone III, and the raw material liquid flows directly into Zone III. The outlet liquid in Zone II is collected regularly, and after replenishing the mobile phase and raw materials, it merges with the raw material liquid and flows into Zone III. The flow rate and switching time of each zone are listed in Table 1. Among the zones I~IV, the pressure in zone III is the highest, which is 3.5Mpa.

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Abstract

The invention relates to an improved chromatographic separation system for an analog moving bed. The separation system can be formed by open-loop series connection of an II region, an III region and an IV region, wherein the number of chromatographic columns of each region is more than and equal to 1; the II region is arranged between an eluent inlet and a feed inlet; the III region is arranged between the feed inlet and a raffinate outlet; and the IV region is arranged between the raffinate outlet and an extract outlet. The separation system can also be formed by the II region, the III region and the IV region in turn, wherein the II region and the III region are disconnected with each other; the III region is in series connection with the IV region; the number of the chromatographic columns of each region is more than and equal to 1; the II region is arranged between the eluent inlet and the feed inlet; the III region is arranged between the feed inlet and the raffinate outlet; and the IV region is arranged between the raffinate outlet and the extract outlet. The separation system can reduce the amount of stationary phase to reduce the cost, and simultaneously can reduce the system pressure and improve the operation stability of the chromatographic separation system for the analog moving bed.

Description

technical field [0001] The invention relates to an improved simulated moving bed chromatographic separation system. Background technique [0002] The Simulated Moving Bed (SMB) was first implemented by UOP Inc. in the petrochemical industry, and has a history of more than 50 years. The simulated moving bed consists of multiple chromatographic columns connected end to end to form a closed loop. The simulated moving bed is divided into four zones by eluent inlet, extract outlet, raw material inlet and raffinate outlet: between the eluent inlet and the extract outlet is called zone I; between the extract outlet and the feed Between the liquid inlet is zone II; between the feed liquid inlet and the raffinate outlet is zone III; between the raffinate outlet and the eluent inlet is zone IV. At regular intervals, the positions of the inlet and outlet of the four materials are moved along the direction of the mobile phase to the outlet of the next column (or each column is moved i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D15/08B01D11/00
Inventor 危凤赵迎宪陈明杰张艳辉
Owner NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG