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Polymer-based anti-cancer agents

A technology of copolymers and block copolymers, applied in cancer treatment, in the field of polymer-based anticancer agents, can solve problems such as side effects and patient pain, relatively ineffective damage, high treatment costs, and imperfections

Inactive Publication Date: 2009-05-13
BRUCE MEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although different approaches to cancer treatment (e.g., chemotherapy, endocrine therapy, radiation therapy, and surgery) have been greatly developed in recent decades, they are still far from perfect in terms of outcomes for different cancer types
In addition, some known cancer treatments are marred by high treatment costs, side effects and patient distress, and relative inefficiency.

Method used

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  • Polymer-based anti-cancer agents
  • Polymer-based anti-cancer agents
  • Polymer-based anti-cancer agents

Examples

Experimental program
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Embodiment

[0124] In embodiments, different amphiphilic block copolymers are used. and Polymers were obtained from BASF Corporation. Amphiphilic block copolymers labeled DORVAL 1 are A variant of the polymer that simply swaps the central propylene oxide chain for the corresponding polystyrene chain. The block copolymer was ordered from PolymerSource, Canada. The polymer has the following schematic structure: (EO)x-(St)y-(EO)x, where x≈70, and y≈27, Mn: PEO(3100)-PSt(2800)-PEO (3100) and Mw / Mn=1.11.

[0125] Growth rate inhibition of breast cancer cells

[0126] detected Effects on cell growth of human breast cancer cell lines cultured in vitro. by incorporation 3 H-thymidine was used to measure growth rate. The rapidly growing breast cancer cell line MCF-7, and the slower growing breast cancer cell line SK-BR-3 were examined.

[0127] Briefly, approximately 3×10 4 cells were seeded on 24-well microtiter plates and cultured overnight (humidified air, 5% CO 2 , 37°C). Afte...

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Abstract

The present invention relates to the use of amphiphilic block copolymers for treating and preventing cancer, and in particular by reducing the proliferation rate of cancer cells. Preferred block copolymers comprises a central hydrophobic chain, preferably a polypropylene oxide chain, two which at least two hydrophilic side chains, preferably polyethylene oxide chains, are connected.

Description

technical field [0001] The present invention relates generally to the treatment of cancer, and in particular to the use of polymer-based anticancer agents in the treatment of such cancer. Background technique [0002] Cancer is a class of diseases characterized by the uncontrolled division of cells and the ability of these cells to spread either by invasion, by direct growth into adjacent tissues, or by metastasis, by implantation in distant sites in the body. [0003] Today, cancer is the leading cause of human death, and the number of individuals affected by the disease is increasing every year. Although different approaches to cancer treatment (e.g., chemotherapy, endocrine therapy, radiation therapy, and surgery) have been greatly developed in recent decades, they are still far from perfect in terms of outcomes for different cancer types . In addition, some known cancer treatment methods are also marred by the disadvantages of high treatment cost, side effects and pati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/765A61K31/785A61P35/00
CPCA61K31/785A61K31/765A61P35/00A61P43/00
Inventor 拉尔斯·布鲁斯英格丽德·布鲁斯
Owner BRUCE MEDICAL
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