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Biological absorbable polymer artificial dressing and preparation method

A polymer and artificial technology, applied in the direction of absorbent pads, rayon manufacturing, single-component polyester rayon, etc., can solve the problems such as the inability to keep the wound surface moist, the dressing fibers fall off easily, and the granulation tissue adheres to the scab. Improve skin wound repair effect, enhance mechanical properties, and improve cell adhesion ability

Inactive Publication Date: 2009-05-27
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Benefits of technology

This patented describes an improved method for making polymers called polygalactides (PGA) by forming fibers from these materials through elecerostatic spinning techniques. These PGAs have unique features such as high strength at breakage levels compared to traditional plastics or rubbers used in medical applications like suturing surgery tissue repairs. Additionally, they also enhance their biodegradability when implanted into living organisms due to its chemical structure. Overall, this new material provides technical benefits over existing methods while improving upon current technologies.

Problems solved by technology

This patented technical problem addressed in this patent is how to create highly durably flexible, conformable, and hygroscopicity-free multifunctional implant systems capable of delivering medications safely through blood vessels while still providing adequacy therapy during treatment procedures (such as hemostatic applications).

Method used

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  • Biological absorbable polymer artificial dressing and preparation method
  • Biological absorbable polymer artificial dressing and preparation method
  • Biological absorbable polymer artificial dressing and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0045] Embodiment 1: use a kind of polylactide-glycolide electrospun fiber membrane loaded with dimethyl sulfone in a mass percentage of 10%, the steps and conditions of its preparation method are as follows:

[0046] (1) Polylactide-glycolide is dissolved in a distilled chloroform, and it is prepared into a solution with a mass volume ratio of 10%;

[0047] (2) dimethyl sulfone is dissolved in acetone, and it is prepared into a solution with a mass volume ratio of 125 mg / ml;

[0048] (3) Then add the solution of step (2) to the solution of step (1), so that the mass percentage of dimethyl sulfone in polylactide-glycolide is 10%;

[0049] (4) The solution of step (3) is placed on a magnetic stirrer to stir;

[0050] (5) Emulsify in an ice bath at 10,000rpm for 15min;

[0051] (6) Pour the solution treated in step (5) into a clean syringe, smear and seal the joint between the syringe push rod and the sleeve with silicone grease, and perform electrospinning;

[0052] (7) The ...

Embodiment 2

[0055] Example 2: A group of polylactide-glycolide electrospun fiber membranes loaded with dimethyl sulfone at a mass percentage of 0.01%, the steps and conditions of its preparation method: step (3) dimethyl sulfone accounts for polypropylene The mass percentage of lactide-glycolide is 0.01%, the flow rate of the solution in step (7) is 2.2ml / h, and the spinning temperature is controlled to be 24° C., and other steps are the same as in Example 1.

[0056] This polylactide-glycolide electrospun fiber membrane loaded with dimethyl sulfone at a mass percentage of 0.01% was used for cell proliferation experiments. Cell proliferation was detected by tetrazolium salt colorimetry. Such as Figure 9 , the results of cell proliferation detection showed that when the mass percentage of dimethyl sulfone was 0.01%, the proliferation rate of cells on the surface of the fiber membrane increased, indicating that the loading mass percentage of polylactide-glycolide with 0.01% dimethyl sulfo...

Embodiment 3

[0057] Example 3 A group of polylactide-glycolide electrospun fiber membranes loaded with dimethyl sulfone at a mass percentage of 0.1%, the steps and conditions of its preparation method: step (3) dimethyl sulfone accounts for polylactide The mass percent of ester-glycolide is 0.1%, the solution flow rate in step (7) is 2.3ml / h, the temperature of the controlled spinning is 22°C, and other steps are the same as in Example 1.

[0058] The polylactide-glycolide electrospun fiber membrane loaded with dimethyl sulfone at a mass percentage of 1% was used for gene expression detection by RT-PCR method. From Figure 10 It can be seen that the expression of type II collagen in the polylactide-glycolide fiber membrane loaded with dimethyl sulfone at a mass percentage of 1% is obvious. It shows that the polylactide-glycolide fiber membrane loaded with 1% mass percentage of dimethyl sulfone can effectively promote the synthesis of type II collagen in cells.

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Abstract

The invention relates to a bioabsorbable polymer artificial dressing and a preparation method. The dressing is a nano-fiber membrane which is prepared by mixing dimethyl sulfone and absorbable polymer biological material-polylactide-glycolide and then using an electrospinning method. The polylactide-glycolide fiber membrane can completely wrap the dimethyl sulfone therein, and the two can be completely mixed to show a homogeneous state; the mixing of the dimethyl sulfone can enhance the mechanical performance of the polylactide-glycolide and improve the mechanical strength thereof, and the polylactide-glycolide fiber membrane can slowly release the dimethyl sulfone. The bioabsorbable polymer artificial dressing can be used for coverings of burns, cutting wounds and other wounds, and the dimethyl sulfone which is carried in the dressing has the function of promoting the wound repair.

Description

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Claims

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Application Information

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Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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