5 results about "Poly d l lactide" patented technology

Disclosed are a composition for inducing immunity against an active ingredient and a method for preparing same, the composition comprising: a nucleic acid, a polypeptide, or a combination thereof as the active ingredient; a cationic compound; an amphiphilic block copolymer; and a polylactate, wherein the active ingredient is encapsulated in a nanoparticle structure formed by the amphiphilic block copolymer and the polylactate.

The invention relates to the technical field of ureteral stents, in particular to a thermo-sensitive bio-absorbable ureteral stent and a preparation method of a drug sustained-release coating thereof.The thermo-sensitive bio-absorbable ureteral stent comprises two polylactic acid anchoring rings, a longitudinal reinforcing radial line, a transverse response radial line, a threaded guide groove and a thermo-sensitive adhesive sheet, a longitudinal reinforcing radial line is annularly arranged between the two polylactic acid anchoring rings, a transverse response radial line is arranged outside the longitudinal reinforcing radial line, and the longitudinal reinforcing radial line and the transverse response radial line form a spiral stent structure. According to the thermo-sensitive bio-absorbable ureteral stent and the preparation method of the drug sustained-release coating thereof, by adjusting the lactide / glycolide ratio in PLGA to be 3: 1 and adding magnesium ion sustained-release particles, an acidic degradation environment is dynamically neutralized, synchronous degradation of a matrix and the coating is ensured, the support failure or inflammation risk is avoided, and sustained release of drugs in the support period of the stent is ensured.

The embodiment of the invention relates to the technical field of medical coating materials, in particular to a method for forming an active coating on the surface of a degradable plugging device and the degradable plugging device, and the method comprises the following steps: preparing a perfluorohexane liposome loaded with stromal cell-derived factor-1 alpha (SDF-1 alpha); preparing nano particles of the polylactic acid-glycolic acid copolymer, the rapamycin and the nitric oxide donor; preparing a methacryloyl gelatin-tannic acid hydrogel carrier; mixing the liposome and the nanoparticles into the hydrogel carrier; and soaking the degradable plugging device in the mixture obtained in the previous step, and carrying out photo-crosslinking treatment on the mixture, so that an active coating is formed on the surface of the degradable plugging device. Therefore, comprehensive consideration of'implantation early endothelial repair-implantation later cardiac muscle tissue remodeling 'is realized, controllable sequential repair of the degradable plugging device on the heart defect part is ensured, and the endogenous function repair effect of the heart of a patient is improved.

Methods for intranasal delivery of a GLP-1 (glucagon-like peptide-1) drug, such as tirzepatide (TZP), using a formulation of the drug encapsulated in poly(lactic-co-glycolic acid) or poly(caprolactone) nanoparticles optionally coated with chitosan and / or polyethylenimine-grafted chitosan at an optimized condition for surface charge change and particle size control are described. The disclosed intranasal formulations successfully provides dosing-dependent body fat loss in mice, showing a significant therapeutic effect.

The application discloses a 4D printing shape memory composite stent for delivering exosomes and magnesium ions and a preparation method and application thereof. The preparation method comprises the following steps: (1) mixing hydroxyapatite and silicon dioxide nanoparticles with poly(D, L-lactic acid-co-trimethylene carbonate) in dichloromethane to obtain an oil phase; adding exosomes into a magnesium oxide nanoparticle water dispersion to obtain an aqueous phase; and mixing to obtain a water-in-oil Pickering emulsion; and (2) using a 4D printing technology to prepare the composite porous shape memory stent (PHS / MgO-EXO) loaded with exosomes by using the Pickering emulsion ink. The stent has a multi-stage interconnected pore structure, and can promote cell osteogenic differentiation and bone tissue regeneration by synergistically releasing exosomes and magnesium ions. The stent also has a temperature-sensitive shape memory function, can restore the original shape under a slightly higher body temperature stimulus, can accurately match irregular bone defects, and is suitable for minimally invasive repair treatment of clinical irregular bone defects.