Medicine releasing system of aliphatic polylactone mixture

A polylactone and aliphatic technology, applied in the field of drug release system, can solve the problems of poor drug permeability, slow degradation rate, and inability to achieve constant drug release.
CN1393267AInactive Publication Date: 2003-01-29INST OF CHEM CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF CHEM CHINESE ACAD OF SCI
Publication Date
2003-01-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

An aliphatic polylactone intermingled material as medicine releasing system contains hydrophilic medicine (1-30 wt. portions) and medicine carrier (100 wt. portions). The mentioned hydrophilic medicine may be 5-fluorouracil, streptomycin, growth factor, etc.. The mentioned carrier is the mixture of PLA, PGA, PCL, PHB, or PHV. Its advantage is constant-speed sustained releasing.
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Description

Technical field:

[0001] The invention relates to a drug release system using a blend of biodegradable aliphatic polylactone homopolymers as a hydrophilic drug carrier. Background technique:

[0002] For a long time, matrix pharmaceutical preparations have been the most commonly used drug delivery system, such as ordinary tablets and drug capsules. The matrix pharmaceutical preparation is generally prepared by uniformly dissolving or dispersing the drug in the drug carrier, and has the characteristics of simple molding method, easy production, and low price. However, this type of drug preparation usually exhibits a "first-order" release behavior, that is, whether it is a tablet preparation, a cylindrical dosage form, or a spherical preparation, there is a burst of drug release at the initial stage, and then the drug release rate continues to decrease. release behavior. This is because matrix pharmaceutical preparations are generally diffusion-controlled drug release dosage ...

Claims

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