33results about How to "Purity" patented technology

A coupling system for the transfer of a flat object from a confinement box towards a processing unit for processing the flat object. The coupling system includes a first shutter, at least one second opening, a second shutter, and a third shutter associated with the second opening on a side facing the processing unit, and devices for releasing the first, second and third shutter, after coupling the transfer opening of the confinement box with the transfer opening of the processing unit, in order to allow the transfer of the object between the confinement box and the processing unit.

Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H / D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear / scalability / performance basis and also from a validation and regulatory basis. In summary, the 10 L bioreactor system disclosed provides for “linear scalability” by using the same or substantially simulating the same vessel geometry, gas sparging system, impeller shape and type, polymer composition of the flexible bag / components, process control system, and shear rates as larger 50-5000 L systems.

The invention relates to a method for continuously manufacturing aligned nanostructures on a running support, which comprises conveying the support through a heated space and synthesising, in this space, aligned nanostructures on the support by catalytic chemical vapour deposition. The heated space is divided into n consecutive zones in the conveying direction of the support (n being an integer ≧2), and the synthesis of the nanostructures results from heating and injection operations, in each of these n zones, of a flux of an aerosol containing a catalytic precursor and a source precursor of the material of the nanostructures to be formed, carried by a carrier gas. The injection operations are made by modifying, in at least two of the n zones, at least one parameter chosen among the flow rate of the carrier gas flux, the chemical composition of the carrier gas, the mass concentration of the catalytic precursor in the catalytic precursor and source precursor mixture. The invention also relates to a device for implementing this method.

Compositions are disclosed which have as a component thereof an inhibitor of the enzymatic production of 3-deoxyglucosone (3DG) from fructoselysine and / or an inactivator of 3DG, and which are useful for the treatment or prophylaxis of a condition or disease state that is alleviated by inhibiting such 3DG production. Methods of using such compositions, e.g., for improving the appearance, texture and / or elasticity of aging skin, are also disclosed.

A process for the production of polylactide, the stages of which for the production and purification of lactide, starting from an aqueous solution of lactic acid or of its derivatives, includes evaporation of water with formation of oligomers, depolymerization to give lactide, condensation and then crystallization of the crude lactide product to give purified lactide, aqueous treatment of the residual fractions from the crystallization and polymerization of purified and / or prepurified lactide to give polylactide in an extruder and in the presence of catalysts. An alternative process includes carrying out the aqueous treatment before the crystallization.

There is provided an aluminum pigment including an aluminum particle having a film formed on a surface thereof, wherein the film contains a metallic amine salt and the metallic amine salt is represented by the compositional formula RmHnN+−O-M(=O)2—OH (wherein M represents a metal element, R represents a hydrocarbon chain optionally having a substituent, m represents an integer of 1 or more, and n represents an integer satisfying n=4-m).

A novel red fluorescent powder of the following formula (I):AB(MO4)2  (I)wherein A is independently Li+, Na+, K+, Rb+, Cs+, or Ag+; B is Europium of trivalent rare-earth ion (Eu3+); and M is molybdenum (Mo) or tungsten(W). The red fluorescent powder prepared by a solid-state method is used in light emitted diodes (LED), particular in white light LEDs. It has strong absorption in the near-UV wavelength of 360 nm to 420 nm, improved luminescence intensity than commercially available, high color purity, luminescent efficiency, and excellent chemical stability.

Provided are a method and a device for synthesizing proteins from DNA molecules captured in microchambers, whereby the distance between microchambers can be shortened, thereby allowing the density of arrays to be increased. Microchambers (32) are arranged at a high density. A DNA solution (34) which has been diluted so as to capture one DNA molecule on average is enclosed in the microchambers (32). Then, mRNA is synthesized using one DNA molecule on average as a template. Based on this mRNA, a protein (37) is extracellularly synthesized.

An evaporator is provided, comprising a heating core shell and a heating core assembly; the heating core assembly comprises a pipe bowl container, a cavity air passage structure, a heating element and a control circuit; the control circuit is configured to heat the heating element according to received trigger signals from different trigger paths, the heating element is configured to conduct heat energy to and evaporate a matter to be evaporated stored in the pipe bowl container, and evaporated gas is guided to outside of the heating core shell through the cavity air passage structure. A control method of the evaporator is also provided. The pipe bowl container is convenient for cleaning, and the control circuit receives signals from different trigger paths to heat the heating element, so as to make the heating working state of the control and operation of the heating element more concise and convenient.

The present invention relates to a cell for producing acyl glycinates wherein the cell is genetically modified to compriseat least a first genetic mutation that increases the expression relative to the wild type cell of an amino acid-N-acyl-transferase,at least a second genetic mutation that increases the expression relative to the wild type cell of an acyl-CoA synthetase, andat least a third genetic mutation that decreases the expression relative to the wild type cell of at least one enzyme selected from the group consisting of an enzyme of the glycine cleavage system, glycine hydroxymethyltransferase (GlyA) and threonine aldolase (LtaE).

The present invention relates to a phosphor for UV and long-wavelength excitation and a preparation method thereof, more particularly to a phosphor for UV and long-wavelength excitation prepared from a phosphor precursor comprising strontium, barium, zinc, silica and rare-earth metal, wherein the proportion of barium and zinc is optimized to obtain a color coordinate in the range of x=0.50-0.64 and y=0.38-0.51, and a method for preparing the same by heat-treating the phosphor precursor under a mixed gas atmosphere of nitrogen and hydrogen with specific proportion. Since heat treatment is possible even at low temperature, a phosphor for UV and long-wavelength excitation having superior luminescence characteristics and thus offering superior efficiency when applied to diodes or liquid crystal displays can be obtained without having to use conventional flux materials to lower baking temperature and without using toxic substances.

The present disclosure provides an adsorption tower for an oxygen generator system configured to adsorb nitrogen in air and supply oxygen, the tower comprising: a housing defining an inner space therein in which an adsorbing agent is filled; a housing inlet through which air enters into the housing; an housing outlet through which air is discharged from the housing, wherein the housing inlet is opposite to the housing outlet; a sodium based adsorbing agent layer disposed in the inner space and adjacent to the housing inlet; and a lithium-based adsorbing agent layer disposed in the inner space and adjacent the housing outlet.

The present invention relates to a process for preparing Ziprasidone of formula I,or a pharmaceutically acceptable salt or a solvate or a hydrate thereof;comprising the steps of reacting 1-(1,2-benzisothiazol-3-yl) piperazine of formula II or its salt:with 5-(2-haloethyl)-6-chloro-oxindole of formula III:wherein X is leaving groups like fluoro, chloro, bromo, iodo or sulphonyl;in the presence of a dispersing agent and a base in a solvent to form ziprasidone of formula I; and optionally converting the ziprasidone formed into a pharmaceutically acceptable acid addition salts of ziprasidone; or a solvate or a hydrate thereof.

The invention relates to a process for extracting ammonium thiosulfate and ammonium thiocyanate from coke-oven gas desulfurization waste liquid, which comprises the following steps of firstly, adsorbing the preliminarily filtered desulfurization waste liquid with activated carbon for deep decoloration treatment, carrying out negative pressure evaporation concentration on the decolorized waste liquid, and then carrying out crystallization separation purification to prepare ammonium thiosulfate and ammonium thiocyanate products. According to the process, fractional crystallization is adopted, the extracted salt does not need to be separated subsequently, the overall process is simple, the cost is low, no pollution is caused to the environment, sulfur in the desulfurization waste liquid is extracted more thoroughly, and the purity of the extracted salt is high and can reach 99% or above.

The invention discloses a low-temperature culture medium for pichia pastoris. The culture medium is favorable for realizing high-density fermentation of the pichia pastoris under the condition of lowtemperature (18-22 DEG C) while increasing the expression quantity of unit thalli. Various proteases in fermentation broth can be inhibited, so that the stability of the product structure can be maintained, and the generation of related impurities of the product can be reduced; When the method is applied to industrial preparation, the expression yield of exogenous proteins can be remarkably increased, and the downstream purification treatment difficulty is reduced. The preparation cost and the processing difficulty of products such as genetically engineered drugs, enzyme preparations and the like taking the pichia pastoris as the host are reduced.

The present invention refers to a process for the purification of levulinic acid, an aqueous solution comprising levulinic acid and a process for the production of levulinic acid.

The present invention provides a method for producing lactic acid in a recombinant yeast cell culture using glucose as carbon source comprising a first, seed fermentation stage to produce biomass wherein the yeast is cultivated in a culture medium at a pH of 5 to 7, followed by a second, a production fermentation stage with biomass from the seed fermentation to produce lactic acid, wherein the yeast is cultivated in a culture medium at low p H using a yeast strain that is engineered to have lactate dehydrogenase (LDH) activity and optionally has decreased or knocked-out pyruvate decarboxylase (PDC) activity.

The present invention provides a cytokine-based culture method for ex vivo expansion of NK cells from postembryonic hematopoietic stem cells into a fully closed, large-scale, cell culture bioprocess. We optimized enrichment of CD34+ cells followed by efficient expansion in gas-permeable cell culture bags. Thereafter, expanded CD34+ cells could be reproducibly amplified and differentiated into CD56+CD3− NK cell products with a mean expansion of more than 2,000 fold and a purity of >90%. Also provided are collections of cultured cells having specific properties.

The present invention relates to a process of producing a monoterpene and / or derivatives thereof. The process comprises the steps of: a) providing a host microorganism genetically engineered to express a bacterial monoterpene synthase (mTS); and b) contacting geranyl pyrophosphate (GPP) with said bacterial mTS to produce said monoterpene and / or derivatives thereof. The present invention also relates to a microorganism for use in producing a monoterpene and / or derivatives thereof and a recombinant microor-ganism adapted to conduct the step of converting geranyl pyrophosphate (GPP) into a monoterpene and / or derivatives thereof by ex-pression of a bacterial mTS. It was shown to produce 1,8 cineole using 1,8 cineole synthase and to produce linalool using linalool synthase, both from Streptomyces clavuligerus.

Compositions are disclosed which have as a component thereof an inhibitor of the enzymatic production of 3-deoxyglucosone (3DG) from fructoselysine and / or an inactivator of 3DG, and which are useful for the treatment or prophylaxis of a condition or disease state that is alleviated by inhibiting such 3DG production. Methods of using such compositions, e.g., for improving the appearance, texture and / or elasticity of aging skin, are also disclosed.

The invention discloses an extruder. The extruder structurally comprises a shaft driving motor, a square cylinder oil scraping sleeve seat, a feeding bundle cylinder groove, a single-screw horizontalgroove, a bearing seat, a base box shell and a storage square box, and realizes that the square cylinder oil scraping sleeve seat is matched with the feeding bundle cylinder groove, meat is guided into a flat square cylinder groove through the feeding bundle cylinder groove; a rotary blade paddle seat in the flat square cylinder groove is mounted in an octagonal inner groove in a sleeving mode, and is connected with a knife sharpening scraping bracket for oil scraping, so that an annular surface knife supporting, oil cleaning and discharging effect is formed; the whole inner and outer shell frames are prevented from permeating oil blocks, the inner self-cleaning and connecting pipe discharge effects are achieved through an oil suction rod ball cylinder, the maintenance degree of a rotatingblade edge surface and the knife supporting millstone effect are improved; then a spiral cutter surface is matched with extrusion operation to rotate and ream the meat paste to form a piled meat density compaction effect, so that the sufficient degree of meat lines and the oil removal operation are improved, the percent of pass of people for purifying extruded meat processing food materials is improved, the internal impurity removal effect of the extruder is optimized, and the processing quality is improved.

It is an object of the present invention to provide a method for synthesizing β-lactams and a method for manufacturing β-lactams in water of high-temperature and under high-pressure, and the present invention relates to a β-lactam synthesis method which is characterized in that β-lactams are synthesized by reacting β-amino acids in water at high-temperature and under high-pressure, this method being further characterized in that β-lactams are synthesized at a high speed by cyclizing β-amino acids in water at high-temperature and under high-pressure in which the temperature range is 200° C. or higher and the pressure range is 10 MPa or greater, and the present invention also relates to a method for manufacturing β-lactams which is characterized in that β-lactams are synthesized by reacting β-amino acids in water at high-temperature and under high-pressure, and are then separated and purified using a column separation medium.

The present invention provides a method for producing lactic acid in a recombinant yeast cell culture using glucose as carbon source comprising a first, seed fermentation stage to produce biomass wherein the yeast is cultivated in a culture medium at a pH of 5 to 7, followed by a second, a production fermentation stage with biomass from the seed fermentation to produce lactic acid, wherein the yeast is cultivated in a culture medium at low p H using a yeast strain that is engineered to have lactate dehydrogenase (LDH) activity and optionally has decreased or knocked-out pyruvate decarboxylase (PDC) activity.

The present invention relates to a phosphor for UV and long-wavelength excitation and a preparation method thereof, more particularly to a phosphor for UV and long-wavelength excitation prepared from a phosphor precursor comprising strontium, barium, zinc, silica and rare-earth metal, wherein the proportion of barium and zinc is optimized to obtain a color coordinate in the range of x=0.50-0.64 and y=0.38-0.51, and a method for preparing the same by heat-treating the phosphor precursor under a mixed gas atmosphere of nitrogen and hydrogen with specific proportion. Since heat treatment is possible even at low temperature, a phosphor for UV and long-wavelength excitation having superior luminescence characteristics and thus offering superior efficiency when applied to diodes or liquid crystal displays can be obtained without having to use conventional flux materials to lower baking temperature and without using toxic substances.

Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single-use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H / D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. The disclosed small scale system models larger scale systems from both a shear / scalability / performance basis and also from a validation and regulatory basis. In summary, the 10L bioreactor system disclosed provides for “linear scalability” by using the same or substantially simulating the same vessel geometry, gas sparging system, impeller shape and type, polymer composition of the flexible bag / components, process control system, and shear rates as larger 50-5000 L systems.

An exemplary single bed reversing blower adsorption based air separation unit is configured to follow the O2 load placed thereon by adjusting flow rates therethrough and power consumption. At least one and preferably multiple pressure sensors sense O2 pressure within an O2 storage region downstream of an adsorber vessel. These sensed pressures are utilized to generate control signals controlling flow rates at locations upstream of the compressor, such as at a reversible blower and an output compressor. Control loops for the blower and the compressor are independent of each other and have different time constants. Effective following of the O2 load is thus achieved without driving the air separation unit into operational conditions outside of design and also maintaining optimal power consumption for the O2 produced, such that efficiency is maintained over a large turndown ratio.

This invention relates to crystals of compounds of formula (I), wherein TBS represents t-butyldimethylsilyl, and Ph represents phenyl, or its salt or solvate. Compounds of formula (I) are synthesis intermediates of 2-substituted-1β-methyl carbapenem compounds useful as antimicrobial agents. The crystals of the present invention have excellent handleability and can realize the production of carbapenem compounds having excellent antimicrobial activity in a simpler manner with improved yield and purity.

The present invention relates to a process of producing a monoterpene and / or derivatives thereof. The process comprises the steps of: a) providing a host microorganism genetically engineered to express a bacterial monoterpene synthase (mTS); and b) contacting geranyl pyrophosphate (GPP) with said bacterial mTS to produce said monoterpene and / or derivatives thereof. The present invention also relates to a microorganism for use in producing a monoterpene and / or derivatives thereof and a recombinant microorganism adapted to conduct the step of converting geranyl pyrophosphate (GPP) into a monoterpene and / or derivatives thereof by expression of a bacterial mTS. It was shown to produce 1,8 cineole using 1,8 cineole synthase and to produce linalool using linalool synthase, both from Streptomyces clavuligerus.

The invention discloses a low-temperature type medium of Pichia pastoris, which is helpful for realizing the expression of Pichia pastoris while increasing the expression amount of a unit cell under the condition of low temperature (18-22° C.). High-density fermentation; it can also inhibit various proteases in the fermentation broth, which is conducive to maintaining the stability of the product structure and reducing the generation of product-related impurities; when applied to industrial preparation, it can significantly improve the expression of exogenous proteins yield and reduce the difficulty of downstream purification. The preparation cost and processing difficulty of genetically engineered medicines, enzyme preparations and other products using Pichia pastoris as a host are reduced.

The invention relates to a furnace (1) for producing a discharge lamp, comprising an outer furnace wall. It is characterized by a hollow body (2) that surrounds the outer furnace wall and is provided to receive discharge vessel parts (4, 5) and joints of the same to a discharge vessel (8) for the discharge lamp. The hollow body (2) further comprises a discharge gas supply (9) for flooding with a discharge gas such that a discharge vessel (8) provided in the hollow body (2) is filled with the same. The invention further relates to a production method for discharge lamps comprising such a furnace (1).