Process of producing monoterpenes

US20200102585A1Inactive Publication Date: 2020-04-02C3 BIO TECH LTD
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
C3 BIO TECH LTD
Publication Date
2020-04-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a process of producing a monoterpene and / or derivatives thereof. The process comprises the steps of: a) providing a host microorganism genetically engineered to express a bacterial monoterpene synthase (mTS); and b) contacting geranyl pyrophosphate (GPP) with said bacterial mTS to produce said monoterpene and / or derivatives thereof. The present invention also relates to a microorganism for use in producing a monoterpene and / or derivatives thereof and a recombinant microorganism adapted to conduct the step of converting geranyl pyrophosphate (GPP) into a monoterpene and / or derivatives thereof by expression of a bacterial mTS. It was shown to produce 1,8 cineole using 1,8 cineole synthase and to produce linalool using linalool synthase, both from Streptomyces clavuligerus.
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Description

FIELD OF THE INVENTION

[0001] The present invention relates to a process of producing monoterpenes. In particular, the present invention relates to a process of producing monoterpenes, for example in a host microorganism, by the action of a bacterial monoterpene synthase.BACKGROUND TO THE INVENTION

[0002] Terpenoids (also called isoprenoids) are the most abundant and largest class (>75000) of natural products. Most commonly found in plants, their biological roles are multitude ranging from species to species communication to intracellular signalling and defence against predatory species. They have a wide range of applications and are used in pharmaceuticals, herbicides, flavourings, fragrances and biofuels. Due to the broad commercial interest for terpenoids, efforts to synthesize them by synthetic biology routes have gathered pace in recent years.

[0003] Terpenoid substrates are synthesized from the C5 isoprene building blocks, namely dimethylallyl pyrophosphate (DMAPP) and isopenteny...

Claims

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