The present invention discloses a preparation method and a compound preparation of
clavulanate potassium. The preparation method comprises: filtering a
Streptomyces clavuligerus
fermentation sequentially with a microporous
filtration membrane, a
polysulfone membrane and an aromatic
polyamide composite membrane; adding
active carbon to the filtrate to decolorize, adding an extractant, transferring and filling into a
pressure resistance container, removing gas bubbles, carrying out sealed oscillation, carrying out
temperature control freezing until the water phase is frozen, taking out, and removing the water phase to obtain an extraction liquid; stirring the extraction liquid while adding a
potassium carbonate solution, transferring and filling into a
pressure resistance container, removing gas bubbles, carrying out sealed oscillation, carrying out
temperature control freezing, taking out, removing the organic phase, slowly adding
acetone in a dropwise manner after the
solid melts, slowly stirring, filtering, washing with
acetone, and carrying out
vacuum drying to obtain
clavulanate potassium; and carrying out sterile mixing on
clavulanate potassium and
amoxicillin according to a weight ratio of 1:5 or on clavulanate
potassium and ticarcillin according to a ratio of 1:15-30. According to the present invention, the preparation method has characteristics of simple process and low cost, and the prepared product has characteristics of low
impurity content and high purity.