Use of diterpenoids from Isodon japonica var.galaucocalyx in preparing anti-cancer medicine

A technology of compound and diterpenes, applied in the field of preparation of anticancer drugs

Inactive Publication Date: 2009-06-17
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] So far, there are no reports about the anticancer activity of cyanine A, cyanine B, cyanine C, cyanine D, cyanine, cyanhex and cyanine X

Method used

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  • Use of diterpenoids from Isodon japonica var.galaucocalyx in preparing anti-cancer medicine
  • Use of diterpenoids from Isodon japonica var.galaucocalyx in preparing anti-cancer medicine
  • Use of diterpenoids from Isodon japonica var.galaucocalyx in preparing anti-cancer medicine

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Experimental program
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Effect test

Embodiment Construction

[0017] The present invention will be described in detail below through in vitro anti-tumor experiments.

[0018] In Vitro Antitumor Activity Test of Elyculin A, Elyculin C, Elyculin D, Elyculin, Elyculin

[0019] 1. Experimental drug:

[0020] R. calyxin A (RJ01), R. calyxin B (RJ02), R. calyxin C (RJ04), R. calyxin D (RJ03), R. calyxin (RJ05), R. calyxin (RJ06) from R. It is isolated from fragrant tea vegetables, and the preparation method is detailed in [Zhao Bao Xiang (xiang Zhaobao), Hai Sheng Chen (陈海生), et al.Two new diterpenoids from Rabdosia japonica var. glaucocalyx, Chinese Chemical Letter 2008; 19:852- 854; Zhao Bao Xiang (xiang Zhaobao), Hai Sheng Chen (Chen Haisheng), et al. Diterpenoids from Rabdosiajaponica Asian Journal of Chemistry 2009; 21:3].

[0021] Control drug: doxycycline (DOX), Shijiazhuang Ruitian Biochemical Co., Ltd.

[0022] 2. Cell line: provided by the Pharmacology Laboratory of Shanghai Institute of Pharmaceutical Industry

[0023] ①A549 (hu...

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Abstract

The present invention relates to technical field of medicine, and relates to the use of diterpenoid compounds of glaucocalyxin A, glaucocalyxin B, glaucocalyxin C, glaucocalyxin D, glaucocalyxin E and glaucocalyxin F in Isodon japonica (Burm f) Hara var glaucocalyx (Max) Hara for preparing anti-cancer medicine. The invention adopts an MTT method for executing cytotoxicity experiment. The result shows that the glaucocalyxin A, glaucocalyxin B, glaucocalyxin C, glaucocalyxin D, glaucocalyxin E and glaucocalyxin F all have remarkable cytotoxicity respectively thereby can be used for preparing the anti-cancer medicine. The invention provides a new source for preparing anti-cancer medicine.

Description

technical field [0001] The invention relates to the technical field of medicine, and is used for the preparation of diterpenoids laminaphyllin A, laminaphyllin B, lamycalyxin C, lamycalyxin, lamycalyxin and lamycalyxin from the tea plant Use of anticancer drugs. Background technique [0002] Glaucocalyxin A (RJ01), Glaucocalyxin B (RJ02), Glaucocalyxin C (RJ04), Glaucocalyxin D (RJ03), Glaucocalyxin Glaucocalyxin E (RJ05) and Glaucocalyxin F (RJ06) are derived from Rabdosia japonica (Burm.f.) Hara var. glaucocalyx (Maxim .) Hara) isolated from the whole herb of Kaurane-type diterpenoids [Guimingyu, et al. Study on the Chemical Constituents of Blue Calyx Fragrant Tea II, Chinese Journal of Pharmaceutical Sciences, 2000; 35(6): 375; Zhao BaoXiang (xiang Zhaobao), Hai Sheng Chen (Chen Haisheng), et al.Two new diterpenoids from Rabdosia japonica var.glaucocalyx, Chinese Chemical Letter2008; 19: 852-854; Zhao Bao Xiang (xiang Zhaobao), Hai Sheng Chen (Chen Haisheng), et al. Di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P35/00
Inventor 陈海生项昭保刘建国金永生赵卫权
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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