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Antihuman Her2 monoclonal antibody hybridoma cell lines, monoclonal antibody, reagent kit and uses thereof

A hybridoma cell line, monoclonal antibody technology, applied in the direction of anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, anti-animal/human immunoglobulin, biochemical equipment and methods, etc. Problems such as specific ligands have not yet been found to achieve high sensitivity

Active Publication Date: 2012-06-27
UNION STEMCELL & GENE ENG
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Problems solved by technology

[0003] Human epidermal growth factor receptor-2 (human epidermal growth factor receptor-2, Her2) is the second member of the epidermal growth factor receptor family (EGFR), and its own specific ligand has not been found yet

Method used

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  • Antihuman Her2 monoclonal antibody hybridoma cell lines, monoclonal antibody, reagent kit and uses thereof
  • Antihuman Her2 monoclonal antibody hybridoma cell lines, monoclonal antibody, reagent kit and uses thereof
  • Antihuman Her2 monoclonal antibody hybridoma cell lines, monoclonal antibody, reagent kit and uses thereof

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Embodiment Construction

[0021] The hybridoma that prepared the mouse anti-human monoclonal antibody that specifically binds to the Her2 antigen molecule was deposited in the General Microbiology Center of the China Microbiology Culture Collection Management Committee CGMCC NO: 2748, and the storage date was 2008-11-19, and the classification was named: mouse anti-human Her2 Hybridoma cell lines.

[0022] Below in conjunction with accompanying drawing and specific embodiment the present invention is described in further detail:

[0023] An anti-human Her2 monoclonal antibody hybridoma cell line, the preservation number of the cell line is CGMCC NO.2748.

[0024] An anti-human Her2 monoclonal antibody is secreted by the hybridoma with the preservation number CGMCC NO.2748.

[0025] The antibody is a murine monoclonal antibody belonging to the IgM / κ subtype.

[0026] The application of the anti-human Her2 monoclonal antibody in the preparation of tumor diagnostic reagents or the detection of guiding t...

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Abstract

The invention discloses an antihuman Her2 monoclonal antibody hybridoma cell line, monoclonal antibody, a kit and the usage. The invention can be combined with human Her2 antigen in specificity in vitro and vivo, so as to indentify the normal or the tumour cells of the human beings according to the Her2 with different levels of expression. The preservation number of the cell line is CGMCC NO.2748, and the monoclonal antibody is secreted by hybrid tumor with the preservation number of CGMCC NO.2748. The antibody is murine monoclonal antibody and belongs to IgM / x subtype. The invention adopts classic hybrid tumor preparation technology to successfully prepare the antihuman Her2 monoclonal antibody, so as to provide an effective detecting way for diagnosticating and guiding to treat tumour, especially breast cancer.

Description

technical field [0001] The present invention relates to an anti-human Her2 monoclonal antibody hybridoma cell line, a monoclonal antibody, a kit and the application thereof, which can specifically recognize human Her2 molecules, and can be used for tumor diagnosis, prognosis judgment, or guiding treatment of tumors. Background technique [0002] Breast cancer is the main malignant tumor that endangers women's health, second only to cervical cancer, and ranks second in the incidence of female malignant tumors. Worldwide, about 1.2 million women are diagnosed with breast cancer each year, and 500,000 women die of breast cancer. North America and Northern Europe are areas with high incidence of breast cancer, and the incidence rate is about four times that of Asia, Africa, and Latin America. my country is an area with low incidence of breast cancer, but its incidence rate is increasing year by year, especially in big cities such as Shanghai, Beijing, Tianjin and coastal areas....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N5/20C07K16/30G01N33/577
Inventor 刘红芹石琳屈浩田晨王冬梅黄丽华张丽艳冯春玲张毅何大水朱卫彬
Owner UNION STEMCELL & GENE ENG
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