Ceftibuten chewable tablet

A technology of ceftibuten and chewable tablets, which is applied in the field of ceftibuten chewable tablets, can solve problems such as inconvenience, and achieve the effect of high quality, good stability and simple method

Inactive Publication Date: 2009-07-01
BEIJING HOPE HUGE PHARM SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the third-generation varieties need to

Method used

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  • Ceftibuten chewable tablet
  • Ceftibuten chewable tablet
  • Ceftibuten chewable tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: specification 1000 pieces

[0033] prescription:

[0034] Ceftibuten 200g 400g

[0035] Sucrose 180g 270g

[0036] Mannitol 250g 350g

[0037] Sodium chloride 10g 15g

[0038] Aspartame 1g 2g

[0039] Strawberry essence 0.4g 0.8g

[0040] Silica 1.5g 3g

[0041] Magnesium Stearate 3g 6g

[0042] 50% ethanol appropriate amount

[0043]

[0044] Preparation method:

[0045] Pass ceftibuten, sucrose, and mannitol through 80-mesh sieve respectively, weigh according to the prescription amount, mix evenly, dissolve sodium chloride in 50% ethanol to make soft material, granulate, dry at 60°C, granulate, and then add additional Excipients strawberry flavor, aspartame, silicon dioxide, magnesium stearate, mixed evenly, the intermediates are subpackaged after passing various quality inspections to obtain

Embodiment 2

[0046] Embodiment 2: specification 10000 pieces

[0047] prescription:

[0048] Ceftibuten 2000g 4000g

[0049] Sucrose 1800g 2700g

[0050] Mannitol 2500g 3500g

[0051] Sodium chloride 100g 150g

[0052] Aspartame 10g 20g

[0053] Strawberry essence 4g 8g

[0054] Silica 15g 30g

[0055] Magnesium Stearate 30g 60g

[0056] 50% ethanol appropriate amount

[0057]

[0058] Preparation method:

[0059] Pass ceftibuten, sucrose, and mannitol through 80-mesh sieve respectively, weigh according to the prescription amount, mix evenly, dissolve sodium chloride in 50% ethanol to make soft material, granulate, dry at 60°C, granulate, and then add additional Excipients strawberry flavor, aspartame, silicon dioxide, magnesium stearate, mixed evenly, the intermediates are subpackaged after passing various quality inspections to obtain

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Abstract

The invention belongs to the technical field of medicaments, a chewable tablet of ceftibuten is used for treating upper respiratory tract infections, such as pharyngitis, tonsillitis, scarlatina, parasinusitis and tympanitis; lower respiratory tract infections, such as acute bronchitis, acute onset of chronic bronchitis and pneumonia; urinary tract infection; enteritis and gastroenteritis. The novel dosage form is characterized in that the product is a chewable tablet chewed or sucked in the mouth to dissolve for administration, and to take effect in the gastrointestinal tract or in the whole body through the absorption of the gastrointestinal tract.

Description

technical field [0001] The invention belongs to the technical field of medicines. A ceftibuten chewable tablet is used for treating upper respiratory tract infections such as pharyngitis, tonsillitis, scarlet fever, paranasal sinusitis and otitis media; lower respiratory tract infections such as acute bronchitis, acute exacerbation of chronic bronchitis and pneumonia ; urinary tract infection; enteritis and gastroenteritis. Specifically, a ceftibuten chewable tablet. Background technique [0002] Cephalosporin antibiotics have the characteristics of broad antibacterial spectrum, strong antibacterial activity, high curative effect, and low toxicity, and have been widely used clinically. By 1998, 56 varieties including the first generation to the fourth generation were on the market in the world. Since the first-generation cephalosporin cephalothin was successfully developed in China in the 1970s, cephalosporin antibiotics have been greatly developed in China. In 2001, the sa...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/546A61P31/04
Inventor 王翰斌闫艳立吴广俣
Owner BEIJING HOPE HUGE PHARM SCI
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