Sustained-release pellet containing ibuprofen

A technology of sustained-release pellets and content, which is applied in the directions of medical preparations containing active ingredients, medical preparations without active ingredients, organic active ingredients, etc. Ask for advanced questions

Inactive Publication Date: 2009-07-01
北京德众万全医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] CN1090477C and CN10102393A respectively disclose a kind of coated granules, which can achieve the purpose of taste masking or sustained release through double-layer coating, but there are relatively high equipment requirements for granule coating, and the equipment conditions of existing domestic manufacturers require large-scale industrial production. There is a certain degree of difficulty
[0009] It controls the release rate of the drug by adding some co-solvents and hydrophilic polymers, but the tablet tends to have large individual differences, and the dissolution has a burst release effect

Method used

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  • Sustained-release pellet containing ibuprofen
  • Sustained-release pellet containing ibuprofen
  • Sustained-release pellet containing ibuprofen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024]

[0025] Coating solution:

[0026]

[0027] Preparation Process:

[0028] Take a certain amount of sucrose blank cores, weigh the raw and auxiliary materials in the prescription and dissolve them in absolute ethanol respectively to prepare a concentration of 80% (medicine-containing) ethanol solution, stir and dissolve, coat the weight to 150%, and dry it Pack into capsules to obtain slow-release capsules each containing 300 mg of ibuprofen.

Embodiment 2

[0030]

[0031] Coating solution:

[0032]

[0033] Preparation Process:

[0034] Take a certain amount of sucrose blank cores, weigh the raw and auxiliary materials in the prescription and dissolve them in absolute ethanol respectively to prepare a concentration of 80% (medicine-containing) ethanol solution, stir and dissolve, coat the weight to 150%, and dry it Pack into capsules to obtain slow-release capsules each containing 300 mg of ibuprofen.

Embodiment 3

[0036]

[0037] Coating solution:

[0038]

[0039] Preparation Process:

[0040] Take a certain amount of sucrose blank cores, weigh the raw and auxiliary materials in the prescription and dissolve them in absolute ethanol respectively to prepare a concentration of 80% (medicine-containing) ethanol solution, stir and dissolve, coat the weight to 150%, and dry it Pack into capsules to obtain slow-release capsules each containing 300 mg of ibuprofen.

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Abstract

The invention relates to a sustained-release pellet containing ibuprofen having an empty core and a medicament-contained coating layer. The inventive pellet can control release of medicament in a better way and stay good stability within a comparatively long time.

Description

Technical field: [0001] The invention relates to a sustained-release pellet, in particular to a sustained-release pellet containing ibuprofen. Background technique: [0002] Ibuprofen, namely 2-(4-isobutylphenyl)propionic acid, is a non-steroidal anti-inflammatory drug (NSAID), and is one of the safest drugs in NSAIDs recognized in the world. It has an effective treatment for rheumatoid arthritis Anti-inflammatory, analgesic, and antipyretic activities necessary for arthritis, osteoarthritis, and other inflammatory conditions. It, together with paracetamol, aspirin, and diclofenac, has become the four pillar products in my country's antipyretic and analgesic drug market, but compared with the other three, ibuprofen has more advantages. Pharmacodynamic studies have proved that: the drug's sedative The pain and antipyretic effects are 28 times and 20 times that of aspirin respectively, and other adverse reactions are less and milder than aspirin. When the body temperature is h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K9/16A61K47/12A61K47/32A61K47/34A61K47/38A61P29/00
Inventor 岳本花
Owner 北京德众万全医药科技有限公司
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