Tibetan oriental wormwood extract as well as preparation method and use thereof

An extract and the technology of the extract of Cangwort Radix are applied in the field of extract, preparation and application of Cangwort Radix, which can solve the problems such as effective components, mechanism of action and safety are not very clear, affecting the application and the like.

Inactive Publication Date: 2009-07-15
MINZU UNIVERSITY OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the past, because the herbal medicine was mainly used by ethnic minorities, the active ingredients, mechanism of action and safety were not very clear, which affected the further clinical application of the medicine

Method used

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  • Tibetan oriental wormwood extract as well as preparation method and use thereof
  • Tibetan oriental wormwood extract as well as preparation method and use thereof
  • Tibetan oriental wormwood extract as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0125] Example 1 Tibetan Yinchen Crude Extract

[0126] 5 kg of dried plant whole grass, roughly crushed, soaked with 6 times the amount (weight) of 75% (wt%) ethanol for 2 hours, and then heated and refluxed for 1-3 hours, such as any one of 2 hours or 1.5-5 hours time, extract twice more in the same way, combine the extracts, recover the solvent ethanol, and obtain the ethanol extract of Capillary wormwood, concentrate it to about 0.95kg, and obtain the crude extract or total extract of Capillary wormwood ZYCT.

[0127]The yield of the crude extract of the Tibetan capillary is about 19%; wherein the content of the total flavonoids in the Tibetan capillary extract is 20%wt of the total weight of the Tibetan capillary extract.

[0128] After detection and pharmacological experiments, the crude extract of the cypress wormwood has the pharmacological effect of resisting liver and gallbladder damage.

[0129] The detection method includes extraction with organic solvents (includ...

Embodiment 2

[0130] Example 2 The preparation of the effective part of the extract of the Tibetan fungi of the present invention

[0131] Add the crude extract or total extract (ZYCT) (950g) of Capillary cypress obtained in Example 1, add water (the mass ratio of water to total extract is about 2:1) to suspend it, add petroleum ether for extraction (The volume ratio of petroleum ether to water is about 2:1) extraction to obtain petroleum ether extract and water layer A, water layer A is added with about the same volume of ethyl acetate as water layer A (extract 2 to 3 times to obtain acetic acid The ethyl acetate extract and the water layer B, the ethyl acetate extract recovers the solvent to obtain the ethyl acetate extract TE (about 95g), and the water layer B is extracted with n-butanol about the same volume as the water layer B for 2 to 3 times , obtain n-butanol extract and water layer, n-butanol extract reclaims solvent and obtains n-butanol extract TN (about 240g), collects TE and T...

Embodiment 3

[0135] Example 3. Isolation and identification of the chemical constituents of the extract (effective fraction or active fraction) of Capillary.

[0136] (1) Systematic separation of chemical components

[0137] The TE obtained in Example 2, i.e., the ethyl acetate extract (90g), was ultrasonically dissolved with 20%wt ethanol, and was put on an AB-8 macroporous adsorption resin column for rough separation of adsorbed impurities, using 40%, 60% , 80% and 95% mass concentration of ethanol for gradient ethanol elution, followed by 40% ethanol elution (EF, 8g), 60% ethanol elution (ES, 12g), 80% ethanol elution (EE, 29g) , 95% ethanol elution (EN, 40g), four polar parts obtained for the adsorption resin chromatogram rough separation, further adopt Si-gel, SephadexLH-20 and the method of HPLC to carry out separation and purification, obtain compound EN1, 2, 3, 4, 5, 6, compounds EE1, 2, 3, 4, 5, 6, and compounds ES1, 2,3.

[0138] The TN obtained in Example 2, that is, the n-but...

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Abstract

The invention provides a Tibetan herba artemisiae capillaris extract which at least contains general flavone. Taking the total weight of the Tibetan herba artemisiae capillaris extract as 100 percent, and the general flavone accounts for 20-75 percent of the Tibetan herba artemisiae capillaris extract. The Tibetan Herba Artemisiae Capillaris extract has the activity of treating diseases in the liver and the gallbladder.

Description

technical field [0001] The present invention relates to an extract from Gentianaceae (Gentianacese) Laryngophyllum long-stalked Laryngophyllum plant unique to the alpine habitat of the Qinghai-Tibet Plateau and a preparation method thereof, and the plant is used as a Tibetan medicine in Tibetan medicine Widely used, the extract has significant medicinal activity for treating hepatobiliary diseases. Background technique [0002] Tibetan Yinchen is a traditional Tibetan medicine that grows in the alpine region. It is one of the eight treasures of Tibetan medicine. In my country, Tibetan medicine is one of the few ethnic medicines with its own unique theoretical system. Its content is rich and systematic, second only to traditional Chinese medicine. A complete ethnic medicine system. Tibetan medicine has unique diagnosis and treatment methods and proven prescriptions for various acute and chronic diseases and difficult diseases such as liver and gallbladder diseases, and has ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/51A61P1/16
Inventor 唐丽冯金朝王文蜀
Owner MINZU UNIVERSITY OF CHINA
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