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aging inhibitor

An aging and preparation technology, applied in food preparation, medical preparations containing active ingredients, medical raw materials derived from angiosperm subphylum, etc., can solve problems such as ignorance of the role of catechins

Active Publication Date: 2015-09-23
KAO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the role of catechins in combination with amino acids or both in suppressing aging-associated declines in muscle mass and muscle strength is largely unknown

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0235] Preparation example 1 (container-packed beverage for anti-aging)

[0236] According to the formulation and conditions shown in Table 11, the aging-suppressing container-packed beverage was prepared. In addition, the composition of the tea extract (tea catechin) in this container-packed drink is shown in Table 12. Both the preservation stability and flavor of this drink were favorable.

[0237] Table 11

[0238] Composition of tea beverages (g / 100mL)

[0239]

green tea drink

oolong tea drink

Green tea extract (g)

Oolong tea extract (g)

Tea extract (g)

Purified water (g)

Sodium ascorbate (g)

17.5

0

0.37

balance

0.05

0

8

0.48

balance

0.05

pH (after sterilization)

5.98

5.87

Sterilization temperature (℃)

133

134

Sterilization heating time (seconds)

30

30

container

PET container

PET container

...

preparation example 5

[0252] Preparation example 5 (chewable tablet for antiaging)

[0253] With the formula containing 180mg ascorbic acid, 50mg citric acid, 12mg aspartame, 24mg magnesium stearate, 120mg crystalline cellulose, 274mg lactose, 540mg tea catechin (TEAFURAN 90S (Ito Garden)), according to the Japanese Pharmacopoeia Tablets were produced in accordance with the provisions of the General Regulations on Preparations "Tablets", and chewable tablets containing catechin were obtained.

preparation example 6

[0254] Formulation example 6 (tablet for aging suppression)

[0255] Tablets containing catechins were prepared according to the usual method with the following formulation. Formula (weight%): tea catechin (Polyphenon 70S (Mitsui Norin)) 20%, sodium malate 20%, palatinose 20%, ascorbic acid 20%, vitamin combination (manufactured by Nippon Fragrance and Pharmaceutical Co., Ltd.) 5%, Crystalline cellulose 5%, sucrose ester 4%, silicon dioxide 1%, eggshell calcium 5%.

[0256] Preparation Example 7 Beverage for prevention of muscle function decline / muscle atrophy suppression / bed-ridden prevention (hereinafter referred to as muscle function decline suppression, etc.)

[0257] According to the formula and conditions shown in Table 14, prepare the preparation of the present invention in the form of tea beverage. In addition, the composition of catechins in this drink is shown in Table 15. Both the preservation stability and flavor of this drink were favorable.

[0258] Table 14 ...

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Abstract

Provision of a drug, a quasi-drug, and a food or beverage, which are effective for senescence inhibition, mitochondrial function improvement, muscle dysfunction inhibition, muscular atrophy inhibition, prevention of a bedridden state, muscle senescence inhibition, or motor function improvement. A senescence inhibitor, a mitochondrial function-improving agent, a muscle dysfunction inhibitor, a muscular atrophy inhibitor, and an agent for preventing a bedridden state, containing a catechin as an effective ingredient. A muscle senescence inhibitor and a motor function-improving agent, containing a catechin and an amino acid as effective ingredients.

Description

technical field [0001] The present invention relates to an aging inhibitor, an agent for improving mitochondrial function, an inhibitor for muscle function decline, an inhibitor for muscle atrophy, a preventive agent for bedridden, an inhibitor for muscle aging, and an agent for improving motor function. Background technique [0002] Aging is roughly divided into physiological aging and pathological aging. Physiological aging is the aging that will inevitably occur with the increase of age. There will be changes in hair, skin, eyes, bones, brain, etc., and the decline of motor function and energy metabolism. In recent years, it has been reported that the variation and damage of mitochondrial DNA, that is, the decline of mitochondrial function, is related to the decline of energy metabolism caused by aging (refer to Non-Patent Document 1). [0003] On the other hand, the decline in muscle strength and endurance caused by aging reduces the ability to perform daily activities....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A23L1/30A61K36/00A61K36/18A61P21/00A61P43/00
Inventor 太田宣康原水聪史村瀬孝利
Owner KAO CORP
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