Protein surface remodeling
A protein, green fluorescent protein technology, applied in the field of protein surface reconstruction, can solve problems such as aggregation troubles
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[0269] Example 1 - Supercharging Proteins Can Confer Great Resilience (Resilience)
[0270] Protein aggregation is a well-known cause of human disease (Cohen, F.E.; Kelly, J.W., Nature 2003, 426, (6968), 905-9; Chiti, F. ); Dobson (Dobson, C.M), Annu Rev Biochem 2006, 75, 333-66; each incorporated herein by reference), are also major challenges facing the use of proteins as therapeutic or diagnostic agents. Problems (Frokjaer, S.; Otzen, D.E., Nature Reviews: Nat Rev Drug Discov 2005, 4, (4), 298-306; Fowler, S.B.); Poon, S.; Muff, R.; Chiti, F.; Dobson, C.M.; Zurdo, J., National Academy of Sciences Proc. (Proc Natl Acad Sci USA) 2005, 102, (29), 10105-10; each incorporated herein by reference). Knowledge of the problem of protein aggregation has been gained from the study of natural proteins. We already know that proteins are least soluble when they carry an isoelectric point of zero net charge (Loeb, J., J Gen Physiol 1921, 4, 547-555, incorporated herein by reference mi...
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