Imidazopyridine derivative containing dioxane-pyridine

Abstract

The invention belongs to the pharmaceutical technical field and specifically relates to imidazopyridine derivatives which are shown in general formula (I) and contain dioxide heterocyclic pyridine, pharmaceutically acceptable salts and isomers thereof, wherein, R<1>, R<2>, R<3> and n are defined as in the specification. The invention also relates to preparation methods of the compounds, drug compositions containing the compounds and the application of the compounds in preparing drugs for preventing and / or treating digestive ulcer.

Description

1. Technical field The present invention belongs to the technical field of medicine, and specifically relates to imidazopyridine derivatives containing dioxacyclopyridines, pharmaceutically acceptable salts and isomers thereof, methods for preparing these compounds, and pharmaceutical compositions containing these compounds. And the application of these compounds in the preparation of medicines for treating and / or preventing peptic ulcer. 2. Background technology Peptic ulcers are caused by ulceration of the gastrointestinal mucosa. These ulcers expose the bottom layer of the lining of the digestive tract to the acidic secretions of the stomach and pepsin. Cell autolysis occurs when there is an imbalance between the intestinal control). It is generally believed that peptic ulcer is caused by this autolysis. Peptic ulcer is one of the common frequently-occurring diseases, and the incidence of ulcer disease accounts for about 10% to 12% of the total population. The initia...

AI Technical Summary

Problems solved by technology

However, this type of drug has a slow onset time and is not strong enough. It takes several doses (and a few days later) to achieve the maximum acid-suppressing effect, and it may not be able to stably suppress acid for 24 hours. The time of taking the drug and eating may affect the drug. Pharmacokinetic parameters, individual differences in pharmacokinetics, and significant interactions with other drugs

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