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Methods and apparatus for reducing noise in mass spectrometry

A mass analyzer and mass spectrometer technology, applied in the field of mass spectrometry, can solve problems affecting and limiting system performance

Active Publication Date: 2009-08-05
AGILENT TECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These two methods will affect and limit the performance of the system
Moreover, even combining these two methods, there is still obvious noise

Method used

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  • Methods and apparatus for reducing noise in mass spectrometry
  • Methods and apparatus for reducing noise in mass spectrometry
  • Methods and apparatus for reducing noise in mass spectrometry

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Embodiment Construction

[0055] Embodiments of the present invention include but are not limited to:

[0056] 1. A method for mass spectrometry analysis of a sample containing an analyte in a mass spectrometer, comprising:

[0057] ionizing the sample to generate ions of an analyte in the sample;

[0058] The resulting ions are separated using the mass-to-charge ratio;

[0059] detecting the separated ions with a detector; and

[0060] A metastable reducing gas is introduced into the mass spectrometer at a point after ionization and before detection.

[0061] 2. The method of embodiment 1, wherein the sample is accompanied by a carrier gas, and wherein the metastable reducing gas is a substance having an excited energy state similar to that of metastable particles of the carrier gas.

[0062] 3. The method of embodiment 2, wherein the metastable reducing gas and the carrier gas are the same substance.

[0063] 4. The method of embodiment 3, wherein both the carrier gas and the metastable reducing ...

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Abstract

The invention pertains to methods and apparatus for performing mass spectrometry with reduced noise. In some embodiment, an ultra amount of carrier gas is lead into the mass spectrograph for reducing the noise.

Description

technical field [0001] The present invention relates to mass spectrometry techniques. More specifically, the present invention relates to methods and apparatus for reducing noise in mass spectrometry. Background technique [0002] Mass spectrometry (MS) is a well-known technique for the identification and quantification of detected sample components. The mass spectrometer can separate the components of the sample analyte according to its mass-to-charge ratio (hereinafter referred to as m / z or m / z ratio). Although there are many different designs for mass spectrometers operating on different separation principles using m / z ratios, most mass spectrometers consist of four basic components. Specifically, almost all mass spectrometers include an ion source for generating ions from a sample, a mass analyzer for separating ions with different m / z ratios, and a mass analyzer for detecting the number of ions generated for each m / z ratio detectors and data analyzers to collect data...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/68
CPCH01J49/0045
Inventor 托马斯·P·多尔蒂杰弗里·T·凯尔南詹姆斯·D·福特
Owner AGILENT TECH INC