Unlock instant, AI-driven research and patent intelligence for your innovation.

Glycyl-L-glutamine pharmaceutical formulation and preparation method thereof

A technology of glutamine and glycyl, applied in the field of medicine, can solve problems such as limited application

Inactive Publication Date: 2009-08-12
大连紫萌科技有限公司
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the solubility and stability of glutamine and other reasons, the clinical application is limited.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1, the preparation of glycyl-L-glutamine injection:

[0012] Weigh 15.135Kg glycyl-L-glutamine and dissolve it in water for injection, add 0.1% (g / v) medicinal activated carbon, stir for 20 minutes to absorb, decarbonize and filter, measure the pH value, and adjust the pH value at 5.0~ Between 6.0, add water for injection to the full amount; after fine filtration through 0.45 μm and 0.22 μm microporous membranes, light inspection, filling into 50ml glass bottles respectively, stoppering, and autoclaving at 116°C for 40 minutes; light inspection ; Finished product inspection, packaging and warehousing, the specification is 50ml: 15.135g injection.

Embodiment 2

[0013] Embodiment 2, preparation of glycyl-L-glutamine injection:

[0014] Weigh 15.135Kg glycyl-L-glutamine and dissolve it in water for injection, add 0.1% (g / v) medicinal activated carbon, stir for 20 minutes to absorb, decarbonize and filter, measure the pH value, and adjust the pH value at 5.0~ Between 6.0, add water for injection to the full amount; after fine filtration through 0.45 μm and 0.22 μm microporous membranes, light inspection, filling into 100ml glass bottles respectively, stoppering, and autoclaving at 116°C for 40 minutes; light inspection ; Finished product inspection, packaging and warehousing, the specification is 100ml: 15.135g injection.

Embodiment 3

[0015] Embodiment 3, preparation of glycyl-L-glutamine injection:

[0016] Weigh 10.185Kg glycyl-L-glutamine and dissolve it in water for injection, add 0.1% (g / v) medicinal activated carbon, stir for 20 minutes to absorb, decarbonize and filter, measure the pH value, and adjust the pH value at 5.0~ Between 6.0, add water for injection to the full amount; after fine filtration through 0.45 μm and 0.22 μm microporous membranes, light inspection, filling into 50ml glass bottles respectively, stoppering, and autoclaving at 116°C for 40 minutes; light inspection ; Finished product inspection, packaging and warehousing, the specification is 50ml: 10.185g injection.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a glycyl-L-glutamine medicine preparation and a preparation method thereof, belonging to the technical field of medicine. The preparation of the invention is a clinical commonly used effective preparation formulation liquid injection which is mainly made of glycyl-L-glutamine and a certain amount of excipients. The glycyl-L-glutamine enters the body and is quickly hydrolyzed into glycin and glutamine, thus playing the functions. The glycyl-L-glutamine medicine preparation is a novel amino acid supplementary preparation by intravenous injection.

Description

Technical field: [0001] The invention relates to a glycyl-L-glutamine pharmaceutical preparation and a preparation method thereof, belonging to the technical field of medicine. This preparation consists of glycyl-L-glutamine. The present invention relates to the formulation of this preparation and its preparation method. Background technique: [0002] In the 1930s, Robert Elemn observed that amino acids in the form of protein hydrolysates could be safely used in humans, which was an important first step towards parenteral nutrition (PN). Total Parenteral Nutrition (TPN) was first reported by Dudric in 1968, that is, all the nutrients needed by the human body are supplied intravenously, including fat emulsion, amino acids, glucose, vitamins, electrolytes and trace elements, so that it cannot be delivered orally. The long-term survival of patients who ingested food is a major achievement in modern nutrition therapy. Indications are for patients who cannot or are not adequat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/05A61K9/08A61P3/02
Inventor 尚宝虎刘晓春
Owner 大连紫萌科技有限公司