Vaccine delivery compositions and methods of use
A composition and vaccine technology, applied in the field of allelic vaccine delivery compositions, can solve problems such as toxicity
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[0296] Synthesis of PEA-antigen conjugates
[0297] [0176] Synthesis of PE4 succinimidyl ester (PEA-Osu). All examples are from N-acetylated polymer (A). PEA 1.392g, 754 μ M, calculated molecular weight MW=1845 per repeating unit (formula I, R 1 =(CH 2 ) 8 ; 2 = H; R 3 =(CH 3 ) 2 CHCH 2 ; 4 =(CH 2 ) 6 ; n=70; m / m+p=0.75 and p / m+p=0.25), which were dissolved in 7 ml of anhydrous DMF under stirring. To this slightly viscous PEA solution was added 0.110 g, 955 [mu]M solid N-hydroxysuccinimide (NHS). 146 mg, 759.8 [mu]M of 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride was transferred as a suspension in DMF. The total volume of DMF used for this reaction was 10 ml. This reaction was carried out at room temperature under a nitrogen atmosphere for 24 hours.
[0298] Synthesis of PEA-influenza peptide conjugates:
[0299] [0177] B1) With a 49.5 μM aliquot of the activated ester (A) in DMF, and 96 mg (49.5 μM) H-PKYVKQNTLKLAT-OH, as the trifluoroacetate s...
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