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A composition and vaccine technology, applied in the field of allelic vaccine delivery compositions, can solve problems such as toxicity
Inactive Publication Date: 2009-08-12
MEDIVAS LLC
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Although many candidate adjuvants are currently under investigation, they suffer from numerous drawbacks, including toxicity in humans and the requirement for sophisticated techniques for introducing antigens
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Embodiment 1
[0296] Synthesis of PEA-antigen conjugates
[0297] [0176] Synthesis of PE4 succinimidyl ester (PEA-Osu). All examples are from N-acetylated polymer (A). PEA 1.392g, 754 μ M, calculated molecular weight MW=1845 per repeating unit (formula I, R 1 =(CH 2 ) 8 ; 2 = H; R 3 =(CH 3 ) 2 CHCH 2 ; 4 =(CH 2 ) 6 ; n=70; m / m+p=0.75 and p / m+p=0.25), which were dissolved in 7 ml of anhydrous DMF under stirring. To this slightly viscous PEA solution was added 0.110 g, 955 [mu]M solid N-hydroxysuccinimide (NHS). 146 mg, 759.8 [mu]M of 1-ethyl-3-(3'-dimethylaminopropyl)carbodiimide hydrochloride was transferred as a suspension in DMF. The total volume of DMF used for this reaction was 10 ml. This reaction was carried out at room temperature under a nitrogen atmosphere for 24 hours.
[0298] Synthesis of PEA-influenza peptide conjugates:
[0299] [0177] B1) With a 49.5 μM aliquot of the activated ester (A) in DMF, and 96 mg (49.5 μM) H-PKYVKQNTLKLAT-OH, as the trifluoroacetate s...
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Abstract
The present invention provides synthetic vaccine delivery compositions based on polyester amide (PEA), polyester urethane (PEUR), and polyester urea (PEU) polymers for stimulating an immune response to a variety of pathogenic organisms and tumor cells in humans and other mammals. The vaccine delivery compositions are formulated as a liquid dispersion of polymer particles or molecules including class I or class II antigen peptides derived from organism or tumor cell proteins, which are taken up by antigen presenting cells of the mammal to induce an immune response in the mammal. Methods of inducing an immune response to the pathogenic organism or tumor cells in the invention compositions are also included.
Description
[0001] related application [0002] [0001] This application claims Provisional Application Serial Nos. 60 / 649,289 filed February 1, 2005, 60 / 689,003 filed June 8, 2005, 60 / 742,188 filed December 2, 2005, 2005 60 / 748,486 filed December 7, 60 / 719,950 filed September 22, 2005, 60 / 687,570 filed June 3, 2005, 60 / 759,179 filed January 13, 2006 at 35 U.S.A. §119 Priority under (e). field of invention [0003] [0002] The present invention relates generally to immunogenic compositions, and in particular to vaccine delivery compositions that bind MHC alleles. technical background [0004] [0003] Although significant advances have been made in vaccine development and administration, alternative ways of enhancing the efficacy and safety of vaccine formulations are still being investigated. Subunit vaccines such as recombinant proteins, synthetic peptides, and polysaccharide-peptide conjugates are emerging as novel vaccine candidates. However, traditional vaccines consisting of attenu...
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