Anhydrous compositions useful for attaining enhanced sexual wellness
A technology of composition and mixture, applied in the direction of drug combination, sexual diseases, drug delivery, etc., can solve problems such as redness, skin irritation, itching, etc.
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Embodiment 1
[0066] Element (%w / w)
[0067] Macrogol 400 75.00
[0068] Propylene glycol 24.60
[0069] Hydroxypropyl cellulose (Klucel HF) 0.30
[0070] Dl-A-tocopherol (alcohol vitamin E) 0.10
[0071] Total 100.00
[0072] The composition of Example 1 was prepared as follows:
[0073] 1. Add the following components to the preparation container:
[0074] Propylene Glycol
[0075] polyethylene glycol 400
[0076] Klucel HF
[0077] 2. Mix with a Silverson mixer while heating to about 50°C (45°C-55°C) until a homogeneous gel is obtained.
[0078] 3. Cool to room temperature
[0079] 4. Add alpha-tocopherol and mix until dissolved.
Embodiment 2
[0081] Element (%w / w)
[0082] Niacin (niacin) 0.10
[0083] Macrogol 400 75.00
[0084] Propylene glycol 24.50
[0085] Hydroxypropyl cellulose (KlucelHF) 0.30
[0086] Dl-A-tocopherol (alcohol vitamin E) 0.10
[0087] Total 100.00
[0088] The composition of Example 2 was prepared as follows:
[0089] 1. Add to the preparation container:
[0090] Propylene Glycol
[0091] polyethylene glycol 400
[0092] Klucel HF
[0093] niacin
[0094] 2. Mix with a Spherson mixer while heating to about 50°C (45°C-55°C) until a homogeneous gel is obtained.
[0095] 3. Cool to room temperature
[0096] 4. Add alpha-tocopherol and mix until dissolved.
Embodiment 3
[0098] Element (%w / w)
[0099] Niacin (niacin) 0.50
[0100] Macrogol 400 75.00
[0101] Propylene glycol 24.10
[0102] Hydroxypropyl cellulose (Klucel HF) 0.30
[0103] Dl-A-tocopherol (alcohol vitamin E) 0.10
[0104] Total 100.00
[0105] The composition of Example 3 was prepared as follows:
[0106] 1. Add to the preparation container
[0107] Propylene Glycol
[0108] polyethylene glycol 400
[0109] Klucel HF
[0110] niacin
[0111] 2. Mix with a Spherson mixer while heating to about 50°C (45°C-55°C) until a homogeneous gel is obtained.
[0112] 3. Cool to room temperature
[0113] 4. Add alpha-tocopherol and mix until dissolved.
[0114] Such as figure 1 As shown, the mean blood flow flux was greater for Example 3, which contained 0.5% niacin, compared to Example 2, which contained 0.1% niacin. Flux is the "rate at which blood flows through a site" or it is the "amount moved". figure 1 The flux or rate of blood flow before sample application and 3 m...
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