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Anhydrous compositions useful for attaining enhanced sexual wellness

A technology of composition and mixture, applied in the direction of drug combination, sexual diseases, drug delivery, etc., can solve problems such as redness, skin irritation, itching, etc.

Inactive Publication Date: 2009-09-30
MCNEIL PPC INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These niacin-containing products, however, are aqueous compositions and, when applied to the skin, cause irritation, itching and / or redness of the skin, also known as a "flushing" reaction, which can last for a considerable period of time

Method used

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  • Anhydrous compositions useful for attaining enhanced sexual wellness
  • Anhydrous compositions useful for attaining enhanced sexual wellness
  • Anhydrous compositions useful for attaining enhanced sexual wellness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Element (%w / w)

[0067] Macrogol 400 75.00

[0068] Propylene glycol 24.60

[0069] Hydroxypropyl cellulose (Klucel HF) 0.30

[0070] Dl-A-tocopherol (alcohol vitamin E) 0.10

[0071] Total 100.00

[0072] The composition of Example 1 was prepared as follows:

[0073] 1. Add the following components to the preparation container:

[0074] Propylene Glycol

[0075] polyethylene glycol 400

[0076] Klucel HF

[0077] 2. Mix with a Silverson mixer while heating to about 50°C (45°C-55°C) until a homogeneous gel is obtained.

[0078] 3. Cool to room temperature

[0079] 4. Add alpha-tocopherol and mix until dissolved.

Embodiment 2

[0081] Element (%w / w)

[0082] Niacin (niacin) 0.10

[0083] Macrogol 400 75.00

[0084] Propylene glycol 24.50

[0085] Hydroxypropyl cellulose (KlucelHF) 0.30

[0086] Dl-A-tocopherol (alcohol vitamin E) 0.10

[0087] Total 100.00

[0088] The composition of Example 2 was prepared as follows:

[0089] 1. Add to the preparation container:

[0090] Propylene Glycol

[0091] polyethylene glycol 400

[0092] Klucel HF

[0093] niacin

[0094] 2. Mix with a Spherson mixer while heating to about 50°C (45°C-55°C) until a homogeneous gel is obtained.

[0095] 3. Cool to room temperature

[0096] 4. Add alpha-tocopherol and mix until dissolved.

Embodiment 3

[0098] Element (%w / w)

[0099] Niacin (niacin) 0.50

[0100] Macrogol 400 75.00

[0101] Propylene glycol 24.10

[0102] Hydroxypropyl cellulose (Klucel HF) 0.30

[0103] Dl-A-tocopherol (alcohol vitamin E) 0.10

[0104] Total 100.00

[0105] The composition of Example 3 was prepared as follows:

[0106] 1. Add to the preparation container

[0107] Propylene Glycol

[0108] polyethylene glycol 400

[0109] Klucel HF

[0110] niacin

[0111] 2. Mix with a Spherson mixer while heating to about 50°C (45°C-55°C) until a homogeneous gel is obtained.

[0112] 3. Cool to room temperature

[0113] 4. Add alpha-tocopherol and mix until dissolved.

[0114] Such as figure 1 As shown, the mean blood flow flux was greater for Example 3, which contained 0.5% niacin, compared to Example 2, which contained 0.1% niacin. Flux is the "rate at which blood flows through a site" or it is the "amount moved". figure 1 The flux or rate of blood flow before sample application and 3 m...

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PUM

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Abstract

The invention relates to an anhydrous composition for attaining enhanced sexual wellness, comprising a vasodilator, for example, a niacin derivative, and an acceptable carrier, wherein the vasodilator such as a niacin derivative, is present in an amount effective to increase the blood flow when the composition is applied to human tissue. The compositions according to the invention are non-flushing.

Description

technical field [0001] The present invention relates to an anhydrous composition for obtaining enhanced sexual pleasure, especially an anhydrous composition comprising a niacin derivative and an acceptable carrier. Background technique [0002] It is estimated that 40 percent of women will experience sexual dysfunction at some point in their lives. Female sexual dysfunction includes a syndrome of arousal, desire, orgasm, and / or painful intercourse. Studies have shown that women achieve orgasm only 25% of the time during pure intercourse. In many cases, physiological factors can be attributed to decreased blood flow to the genital area, especially the clitoris. [0003] Prescription and over-the-counter drugs, illicit drugs, and alcohol abuse lead to sexual dysfunction. There is a different list of drugs or agents that can cause libido disorders, drugs that can cause arousal disorders, and drugs that can cause orgasmic disorders. [0004] Women with sexual dysfunction are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/455A61P15/10
CPCA61K31/455A61K9/0034A61P15/00A61P15/02A61P15/08A61P15/10A61P15/12A61P9/00A61P9/08
Inventor N·艾哈迈德M·乔伊斯S·皮特
Owner MCNEIL PPC INC
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