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Artificial substrate membrane emulsifying paste for wound surface restoration

A technology of artificial basement membrane and cream, which is applied in the directions of ointment delivery, emulsion delivery, and cosmetic preparations, etc., can solve the problems of limited action, no protective effect of wound surface, lack of cell growth platform, etc., and achieves good stability and product quality. Stable quality, uniform and fine finished product

Inactive Publication Date: 2009-12-09
彭强 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the lack of an effective cell growth platform and no protective effect on wounds, this type of drug is limited.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Prescription 1

[0011] Humanoid Collagen 10g

[0012] Recombinant Human Epidermal Growth Factor 10000IU(2mg)

[0013] Silver Sulfadiazine 1g

[0014] Medical Vaseline 5g

[0015] Glycerin 5g

[0016] Distilled water up to 100g

[0017] Preparation method: take medical human-like collagen freeze-dried solid raw material, dissolve with distilled water; add recombinant human epidermal growth factor, dissolve and stir evenly at a temperature of 4°C; add silver sulfadiazine, dissolve and stir evenly; add medical vaseline And glycerin, add distilled water, put into particle size and be ground into emulsifiable paste in the colloid mill of 200 objects. Pour into a tubular container, seal it, and store it at 4°C to 10°C. The whole process is done in a sterile environment.

Embodiment 2

[0019] Prescription 2

[0020] Human Collagen 30g

[0021] Recombinant Human Epidermal Growth Factor 20000IU(4mg)

[0022] Silver Sulfadiazine 2g

[0023] Medical Vaseline 2g

[0024] Glycerin 5g

[0025] Distilled water up to 100g

[0026] Preparation method: with embodiment 1.

Embodiment 3

[0028] Prescription 3

[0029] Humanoid Collagen 25g

[0030] Recombinant Human Epidermal Growth Factor 20000IU(4mg)

[0031] Silver Sulfadiazine 2g

[0032] Glycerin 5g

[0033] Dimethyl sulfoxide 0.1g

[0034] Distilled water up to 100g

[0035] Preparation method: take medical human-like collagen freeze-dried solid raw materials, dissolve in distilled water; add recombinant human epidermal growth factor, dissolve and stir evenly at a temperature of 4°C; add silver sulfadiazine, dissolve and stir evenly; add dimethyl base sulfoxide and glycerin, add distilled water, put into a colloid mill with a particle size of 200 mesh, and grind it into a cream. Pour into a tubular container, seal it, and store it at 4°C to 10°C. The whole process is done in a sterile environment.

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Abstract

The invention provides an artificial substrate membrane emulsifying paste as well as a preparation method and an application thereof. An artificial substrate membrane emulsifying paste composite biological preparation comprises the following components in percentage by weight: 1-60 percent of human-like collagen, 0.001-0.01 percent of epidermal growth factor, 0.5-5 percent of flamazine, 20-95 percent of distilled water and 1-20 percent of medical emulsifying paste matrix. The artificial substrate membrane emulsifying paste can be used for treating wound surfaces of burning, scalding, frostbite and cauma, a skin donor site wound surface, and the like and promoting various fresh wound surfaces and chronic ulcer wound surfaces (including diabetes mellitus, vascellum and radiation ulceration), and the like to be healed and being applied to treat injurious and ulcerous eye diseases and prepare cosmetics and facial beautifying products. The artificial substrate membrane compound has the function of protecting the wound surfaces and can promote epidermal cell growth and wound surface restoration. The emulsifying paste has the advantages of simple and convenient preparation technology, stable product quality and wide application range and is suitable for industrialized production.

Description

technical field [0001] The invention belongs to the technical field of biological preparations. In particular, it relates to an artificial basement membrane cream for wound repair, a preparation method and application thereof. Background technique [0002] At present, there are two main categories of drugs that promote wound healing. One type is the spray prepared by various Chinese medicine ingredients, such as burn spray etc., its main function is to promote the healing of the wound surface through the effects of Chinese medicine such as promoting blood circulation and promoting muscle growth. These medicines have a better effect on burns and scalds, but are less effective on common wounds, foot gangrene, keratitis, tympanic membrane perforation, decubitus ulcers, oral ulcers, and diabetic refractory skin wounds. The other type is biological agents containing various cytokines, such as epidermal growth factor spray, etc., which mainly promote wound healing by promoting t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61K8/64A61K9/06A61K47/42A61K47/10A61K47/20A61K47/36A61P17/02A61P1/02A61P27/02A61P17/00A61Q19/00A61K38/18A61K31/505A61K31/7036
Inventor 彭强李先华
Owner 彭强
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