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Method for preparing changyanning granules

A technology of enteritis and granules, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve problems such as difficult mixing of medicinal powder and excipients, uneven content of finished products, and uncontrollable quality , to achieve the effect of avoiding uneven content, good mixing effect and low cost

Active Publication Date: 2010-03-10
HAINAN HULUWA PHARMA GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the spray-dried powder has the characteristics of light weight, poor fluidity, and strong hygroscopicity. During the granulation process, there is a problem that the powder and auxiliary materials are not easy to mi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Weigh the following ingredients by weight:

[0036] Dijin grass 6.6Kg, yellow hair ear grass 9Kg, camphor root 6.6Kg, fenugreek 3.3Kg

[0037] Maple leaves 3.3Kg dextrin 0.33Kg lactose 0.67Kg;

[0038] Prepare as follows:

[0039] (1) Weigh dextrin and lactose, dry them at 50°C for 5 hours respectively, pass through an 80-mesh sieve, and set aside;

[0040] (2) For the above five flavors, add water to decoct twice, add water 230.4kg for the first time, add water 201.6kg for the second time, each time for 2 hours, combine the filtrate, filter, and concentrate the filtrate to a clear paste with a relative density of 1.20 at 80°C 14.6kg; then add 29.2kg of ethanol with a concentration of 95% by volume, stir, stand, filter, and the filtrate is concentrated to 5.6kg of secondary clear paste with a relative density of 1.20 at 80°C; then add 100g of the above-mentioned dried dextrin , spraying and drying under the conditions of nozzle speed of 15000 rpm, air inlet temperatu...

Embodiment 2

[0043] Weigh the following ingredients by weight:

[0044] Dijin grass 5Kg, yellow hair ear grass 10Kg, camphor tree root 5Kg, fenugreek 2Kg

[0045] Maple leaves 4Kg dextrin 0.2Kg lactose 0.5Kg;

[0046] Prepare as follows:

[0047] (1) Weigh dextrin and lactose, dry at 60°C for 8 hours respectively, pass through 80-mesh sieve, and set aside;

[0048] (2) The above five flavors are decocted twice, adding 208kg of water for the first time, and 182kg of water for the second time, each time for 2 hours, combining the filtrate, filtering, and concentrating the filtrate to 12.7kg of a clear paste with a relative density of 1.18 at 80°C. Then add 25.4kg, volume percent concentration is 95% ethanol, stir, leave standstill, filter, and the filtrate is concentrated to 80 ℃ of relative densities and is the secondary clear cream 11.5kg of 1.05; Then add the above-mentioned dry dextrin of 200g, in Spray drying was carried out under the conditions of nozzle speed 10000 rpm, air inlet tem...

Embodiment 3

[0051] Weigh the following ingredients by weight:

[0052] Dijin grass 10Kg, yellow hair ear grass 8Kg, camphor tree root 10Kg, fenugreek 4Kg

[0053] Maple leaves 2Kg dextrin 0.5Kg lactose 0.8Kg;

[0054] Prepare as follows:

[0055] (1) Weigh dextrin and lactose, dry at 80°C for 2 hours respectively, pass through 80-mesh sieve, and set aside;

[0056] (2) The above five flavors are decocted twice, adding 272kg of water for the first time, and 238kg of water for the second time, each time for 2 hours, combining the filtrate, filtering, and concentrating the filtrate to 15.2kg of a clear paste with a relative density of 1.22 at 80°C. Then add 30.4kg, volume percent concentration is 95% ethanol, stir, leave standstill, filter, and the filtrate is concentrated to 80 ℃ of relative density and is the secondary clear cream 4.2kg of 1.25; Then add the above-mentioned dry dextrin of 50g, in Spray drying was carried out under the conditions of nozzle speed of 18000 rpm, air inlet t...

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Abstract

The invention discloses a method for preparing changyanning granules, which comprises the following steps: weighing the following raw materials in parts by weight: 5-10 parts of heba euphorbiae humifusae, 8-10 parts of goldhair hedyotis herb, 5-10 parts of camphor tree root, 2-4 parts of elsholtzia ciliata, 2-4 parts of maple tree leaf, 0.2-0.5 part of dextrin and 0.5-0.8 part of lactose; preparing an extract after leaching the five traditional Chinese medicinal materials by water and alcohol, preparing medicinal powder after mixing, spraying and drying the extract and a right amount of dextrin, mixing the medicinal powder and the remanent auxiliary materials thrice and preparing the changyanning granules by granulating in a dry method. The changyanning granules prepared by the method havestable, controllable and uniform quality, simple operation, short production period, no need of special equipment, low cost and high yield and are suitable for industrialized production.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a preparation method of Changyanning Granules. Background technique [0002] Existing Changyanning preparations are generally made from the five flavors of traditional Chinese medicines such as Dijincao, Pleurotus chinensis, camphor tree root, fenugreek and maple leaves. Diseases, dyspepsia in children, is currently one of the most commonly used gastrointestinal drugs. [0003] Most of the preparations of Changyanning are based on the quality standard of Changyanning syrup (WS 3 The syrup prepared by -B-3597-98) has high sugar content, which is unfavorable for diabetics to take, large volume, inconvenient transportation and storage, and easy mildew and other shortcomings. If it is made into granules, it is beneficial to divide doses, it is convenient to take, easy to transport and store, and it is made into solid preparations, which improves the stability of the drug....

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K9/16A61K47/36A61P1/00A61P1/12A61P1/14
Inventor 刘全国吴文安
Owner HAINAN HULUWA PHARMA GRP CO LTD
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