Crosslinked polyallylamine or acid addition salt thereof, and use thereof for medical purposes
An acid addition salt, polyallylamine technology, applied in the field of cross-linked polyallylamine or its acid addition salt and its medicinal uses, can solve the problems of low swelling degree, no disclosure of phosphoric acid adsorption capacity, etc., and achieves alleviation of constipation , the effect of high phosphoric acid selectivity
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Example Embodiment
[0091] Example
[0092] The present invention will be described in more detail based on the following examples, but the present invention is not limited to these examples.
Example Embodiment
[0093] (Reference example 1) Synthesis of allyl ammonium dihydrogen phosphate
[0094] In a three-necked round bottom flask equipped with a mechanical stirrer and a thermometer, 46.1 g (0.40 mol) of phosphoric acid (85%) and 500 mL of ethanol were added, and 30.0 mL (0.40 mol) of allylamine was added under an ice bath. After stirring for 30 minutes at room temperature, the precipitated white crystals were filtered and washed thoroughly with ethanol. It was dried under reduced pressure at 60°C, thereby obtaining 59.6 g of allyl ammonium dihydrogen phosphate.
Example Embodiment
[0095] (Reference Example 2) Synthesis of N,N'-diallyl-1,3-diaminopropane and its diphosphate
[0096] In the flask, 38.0 mL (0.40 mol) of 1,3-dichloropropane and 300 mL (4.00 mol) of allylamine were added, and heated and stirred at an internal temperature of 50 to 52° C. for 16 hours in an argon atmosphere. About half of the excess allylamine was distilled off under reduced pressure, and an aqueous potassium hydroxide solution (prepared by dissolving 48 g of potassium hydroxide in 144 g of water) was added. The precipitated salt was removed by filtration, and the filtrate was further pressurized and concentrated to about half of the amount. After extraction with diethyl ether, the organic layer was dried with sodium sulfate, and concentrated under reduced pressure to obtain an oily crude product. The crude product (42 to 44°C / 0.3 kPa) was distilled under reduced pressure to obtain 38.4 g of N,N'-diallyl-1,3-diaminopropane. Add 15.0g (130mmol) of phosphoric acid (85%) and 300mL...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap