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Method for quantum dot improvement and synchronous monitoring of antibacterial performance of ceftriaxone sodium

A technology of ceftriaxone sodium and quantum dots, applied in the field of biomedicine, can solve the problems of high cost, uncontrollable dosage, etc., and achieve the effects of high bacteriostatic effect, low cost, and easy availability of raw materials

Inactive Publication Date: 2010-04-07
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, nano-gold, silver and other materials have been used in combination with conventional antibiotics, and achieved good results, but at the same time, there are disadvantages such as high cost and uncontrollable dosage.

Method used

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  • Method for quantum dot improvement and synchronous monitoring of antibacterial performance of ceftriaxone sodium
  • Method for quantum dot improvement and synchronous monitoring of antibacterial performance of ceftriaxone sodium
  • Method for quantum dot improvement and synchronous monitoring of antibacterial performance of ceftriaxone sodium

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Experimental program
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Effect test

Embodiment 1

[0022] (1) Quantum dot synergistic method of ceftriaxone sodium antibacterial properties

[0023] 0.0319g tellurium powder and 0.0539g NaBH 4 Pour into three-necked flasks respectively, inject 3ml of water, quickly seal, and pass through N 2 To discharge the air in the reaction system, then put the three-necked flask into a 60°C water bath, and react under the stirring of a magnetic stirrer to generate an oxygen-free tellurium hydride solution (NaHTe), and the concentration in 50ml of nitrogen saturation is 5× 10 -3 mol / LCdCl 2 Add 96 μl thioglycolic acid to the aqueous solution, adjust the pH of the solution to 11-11.4 with 0.1mol / L NaOH, and use N 2 Deoxidize for 20min, then quickly add the oxygen-free tellurium hydride solution prepared above, Cd 2+ : Te 2- : MPA mol ratio is 1: 0.5: 2.4 (molar ratio), continue to stir 20min, obtain the original solution of orange-yellow transparent CdTe quantum dot; Get the original solution of CdTe quantum dot and join in the polytet...

Embodiment 2

[0032] Under the condition of ultrasonic stirring, the CdTe quantum dot solution obtained by the reaction was mixed with the commercially available ceftriaxone sodium solution according to the mass concentration ratio of 480:1, and stirred for 30min to obtain the sufficient mixing of the two to achieve the antibacterial properties of ceftriaxone sodium. synergy. As can be seen from the changes in the diameter of the inhibition zone in Table 1, the same synergistic antibacterial performance is better than that of the two used alone.

Embodiment 3

[0034] Under the condition of ultrasonic stirring, the CdTe quantum dot solution obtained by the reaction was mixed with the commercially available ceftriaxone sodium solution according to the mass concentration ratio of 960:1, and stirred for 30min to obtain the two fully mixed to enhance the antibacterial properties of ceftriaxone sodium. effect. As can be seen from the changes in the diameter of the inhibition zone in Table 1, the same synergistic antibacterial performance is better than that of the two used alone.

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Abstract

The invention belongs to the technical field of biomedical and particularly relates to a method for the quantum dot improvement and synchronous monitoring of antibacterial performance of ceftriaxone sodium. Cadmium telluride quantum dots serving as inorganic nano material are added in merchant ceftriaxone sodium to improve the antibacterial performance of the merchant ceftriaxone sodium. Antibacterial experiments performed by taking Escherichia coli as an example indicate that the cadmium telluride quantum dots have a remarkable coordination and improvement effect, which is far better than those achieved by the single use of the cadmium and telluride, on the antibacterial performance of the ceftriaxone sodium. Meanwhile, the number of bacteria and medicament antibacterial performance are synchronously monitored by using the change in the fluorescence intensity of the mixed solution of ceftriaxone sodium and the cadmium telluride quantum dots in an antibacterial process. Thus, a foundation is laid for the effective judgment of the treatment course and withdrawal time of a medicament.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a quantum dot synergistic and synchronous monitoring method for the antibacterial performance of ceftriaxone sodium. Background technique [0002] For a long time, in the clinical application of drugs, people have been pursuing how to achieve greater efficacy. There are two main ways to improve drug efficacy, the first is to develop new drugs to continuously enhance the efficacy of drugs, and the second is to increase the dosage of drugs. However, due to the long-term use of drugs, the efficiency will decrease and the impact of bacterial resistance will often lead to the reduction of drug efficacy, so that excessive drugs are often used in clinical treatment. At the same time, it will cause that the course of treatment of the medicine cannot be correctly grasped, which will bring multiple burdens such as economically, physically and mentally to the patient. [0...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61P31/04G01N21/64A61K31/546
CPCY02A50/30
Inventor 吴庆生罗志辉张孟
Owner TONGJI UNIV
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