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Compound capsule of climbing entada seed for reducing blood sugar, preparation method and application thereof

The technology of Muyazi and capsules is applied in the field of compound Muyazi hypoglycemic capsules, which can solve the problems of major side effects and troubles, and achieve the effects of long storage period, overcoming poor stability, and being easy to take and carry.

Active Publication Date: 2010-05-05
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Insulin for injection has been developed into a long-acting sustained-release preparation administered by injection once a day from the initial injection three times a day, but patients still need daily injections, which is troublesome; and the pharmacological effects of oral hypoglycemic drugs There are a lot of research reports, which can be divided into three categories according to their basic chemical structure: namely sulfonylureas, biguanides and α-glucosidase inhibitors, all of which are chemical drugs, and if taken for a long time, there are relatively large side effects; and Due to the small side effects of traditional Chinese medicine, it is suitable for long-term use, and it is easy to stabilize blood sugar: this invention is based on excavating and sorting out Uyghur medical theory, combined with Uyghur medicine and modern Chinese medicine theory, carefully screened and designed, and developed a Uyghur new drug prescription. Improve the research level of Uyghur medicine

Method used

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  • Compound capsule of climbing entada seed for reducing blood sugar, preparation method and application thereof
  • Compound capsule of climbing entada seed for reducing blood sugar, preparation method and application thereof
  • Compound capsule of climbing entada seed for reducing blood sugar, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: (based on making 1000 grains)

[0024] a. First weigh 265g of the raw material medicine Kiloba chinensis and 60g of myrobalan, grind them into coarse powder according to the conventional method, mix them with 20g of safflower, 100g of cumin, 10g of celery seed and 45g of immortelle, and add 5 times the amount of water to reflux for extraction 1 time, time 1 hour, filter, temperature 40°C, filtrate is concentrated under reduced pressure to an extract with a relative density of 1.20-1.35, temperature is 40°C, concentrated under reduced pressure, dried to obtain extract powder, crushed, passed through a 40-mesh sieve, and set aside ;

[0025] b. Add 26g of auxiliary materials starch and 26g of microcrystalline cellulose to the extract powder of step a, mix evenly, make soft material with 50% ethanol according to conventional pharmaceutical methods, granulate with 14 mesh sieve, dry at 40°C, and sieve with 14 mesh granules, add 1g of magnesium stearate, mix e...

Embodiment 2

[0028] Embodiment 2: (based on making 1000 pieces)

[0029] a. First weigh 397g of the raw material medicine Kidney Kidney, 90g of Myrobalan, and grind them into coarse powder according to the conventional method, mix them with 30g of safflower, 150g of fennel, 15g of celery seed and 68g of Helichrysum chrysanthemum, add 6 times the amount of 50% ethanol to reflux Extract twice, each time for 2 hours, filter at a temperature of 45°C, recover ethanol from the filtrate under reduced pressure and concentrate it to an extract with a relative density of 1.20-1.35, at a temperature of 45°C, concentrate under reduced pressure, dry to obtain extract powder, pulverize, pass 50 mesh sieve, spare;

[0030] b. Add 39g of auxiliary materials starch and 39g of microcrystalline cellulose to the extract powder in step a, mix evenly, make soft material with 60% ethanol according to conventional pharmaceutical methods, granulate with 16 mesh sieve, dry at 45°C, and sieve with 16 mesh granules,...

Embodiment 3

[0033] Embodiment 3: (based on making 1000 pieces)

[0034] a. First weigh 500g of the raw material medicine Kiloba chinensis and 110g of myrobalan, grind them into coarse powder and mix them with 45g of safflower, 200g of cumin, 20g of celery seed and 80g of immortelle, and add 30 times the amount of water to reflux for extraction 3 times, 1 hour each time, filter, the temperature is 50°C, the filtrate is concentrated under reduced pressure to an extract with a relative density of 1.20-1.35, the temperature is 50°C, concentrated under reduced pressure, dried to obtain extract powder, crushed, and passed through a 60-mesh sieve, spare;

[0035] b. Take 52g of auxiliary materials starch and 52g of microcrystalline cellulose, add the extract powder of step a, mix evenly, make soft material with 70% ethanol according to the conventional pharmaceutical method, granulate with 15 mesh sieve, dry at 50°C, and sieve with 15 mesh granules, add 2g of magnesium stearate, mix evenly, and...

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Abstract

The invention relates to a pure traditional Chinese medical compound capsule of climbing entada seed for reducing blood sugar, prepared from raw medicinal materials: climbing entada seed, safflower, common fennel, celery seed, myrobalan and strawflower and assistant materials: starch, microcrystalline cellulose and magnesium stearate. Proved by a pharmacodynamic test, the compound capsule has the functions of regulating blood fat and reducing the blood sugar, has the advantages of high safety, good stability and no obvious toxic or side effects and medicine resistant property, is used for treating type I diabetes and type II diabetes and is also used as a preventive medicament for reducing the blood sugar for long-term use.

Description

technical field [0001] The invention relates to a compound muyaozi hypoglycemic capsule (hard capsule) prepared from medicinal materials commonly used in traditional Chinese medicine and ethnic medicine and used for preventing and treating diabetes. Background technique [0002] The prevalence of diabetes in China is constantly increasing, with an estimated annual growth rate of about 1%. It is estimated that the number of people suffering from diabetes in China will reach 63 million by 2010, and the total number will rank first in the world. Therefore, finding effective drugs for the prevention and treatment of diabetes has become a Important tasks at present. [0003] At the American Diabetes Annual Conference in 2001, Mc Garry proposed at the conference that abnormal lipid metabolism is the root of T2DM and its complications, and T2DM was called "DiabetesMellipidtus". The third report (NCEP ATP III) pointed out that diabetes is a risk equivalent disease of coronary heart...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61K9/48A61P3/10
Inventor 阿吉艾克拜尔·艾萨陈君李名学仲婕唐育中马依努尔·拜克力孙玉华
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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