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A coprostasis curative and production method thereof

A manufacturing method and constipation technology, which can be applied in the direction of pharmaceutical formulations, drug combinations, medical preparations containing active ingredients, etc., can solve problems such as insufficiency, and achieve the effects of reducing harmful substances, high swelling multiples, and excellent ingestibility

Inactive Publication Date: 2012-11-07
SS PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Then, as a study to improve water dispersibility, for example, a technique of adding sugars to improve water dispersibility and quick-acting properties (Patent Document 1), a technology containing a water-soluble polymer and a silicic acid compound (Patent Document 1) are known. 2), the method of dispersing in fats and oils (patent document 3), the technique of blending magnesium oxide, etc. (patent document 4), etc., but these are not sufficient, and the waste (stool) that stays in the intestine can be discharged smoothly Looking forward to further improvement

Method used

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  • A coprostasis curative and production method thereof
  • A coprostasis curative and production method thereof
  • A coprostasis curative and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Manufacture of constipation treatment medicine (1):

[0062] According to the prescription (per day) of the following Table 1, each constipation treatment drug was produced by the following production method. In addition, the cross-sections of each of the manufactured drugs for treating constipation were observed with an electron microscope. The electron micrographs of the cross-sections of each constipation treatment drug are shown in Figure 1~4 .

[0063] [Table 1]

[0064]

Product of the present invention 1

Comparative product 1

Comparator 2

Comparator 3

seed coat of psyllium ovale

4400

4400

4400

4400

Polyoxyethylene (160) polyoxypropylene (30) diol 1)

20

-

-

-

Sucrose Stearate 2)

-

-

20

-

Polyoxyethylene (20) sorbitan oleate 3)

-

-

-

20

Aloe Vera Extract 4)

375

375

375

375

...

Embodiment 2

[0136] Manufacture of medicine for treating constipation (2):

[0137] According to the following prescription (per day), a constipation treatment drug (product 2 of the present invention) was produced in the same manner as in Example 1.

[0138] (prescription)

[0139] Ingredient content (mg)

[0140] Seed coat of psyllium ovale 4000

[0141] Polyoxyethylene (160) polyoxypropylene (30) diol 1) 20

[0142] Aloe Vera Extract 2) 375

[0143] Minced water chestnut 500

[0144] Calcium sennoside 3) 40

[0145] Sweetener 100

[0146] Excipient 500

[0147] Fluidizer 24

[0148] Appropriate amount of spices

[0149] 1) PLONON#188P (manufactured by NOF Corporation)

[0150] 2) Converted to the original drug is 750mg

[0151] 3) Based on the total amount of sennoside A and sennoside B, it is 14.4mg

[0152] Like the product of the present invention 1, the product of the present invention 2 is excellent in the improvement effect...

Embodiment 3

[0154] Manufacture of constipation treatment medicine (3):

[0155] According to the following prescription (per day), a constipation treatment drug (product 3 of the present invention) was produced in the same manner as in Example 1.

[0156] (prescription)

[0157] Ingredient content (mg)

[0158] Seed coat of psyllium ovale 3000

[0159] Polyoxyethylene (160) polyoxypropylene (30) diol 1) 15

[0160] Aloe Vera Extract 2) 300

[0161] Minced water chestnut 500

[0162] Calcium sennoside 3) 40

[0163] Smilax powder 150

[0164] sweetener 30

[0165] Excipients 220

[0166] Fluidizer 24

[0167] Appropriate amount of spices

[0168] 1) PLONON#188P (manufactured by NOF Corporation)

[0169] 2) Converted to the original drug is 600mg

[0170] 3) 14.4 mg based on the total amount of sennoside A and sennoside B

[0171] Like the product of the present invention 1, the product of the present invention 3 is exce...

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Abstract

The invention provides a coprostasis curative, which takes seed vessel of blonde psyllium as effective ingredient, and can discharge waste (stubborn stool) in the intestine smoothly. The coprostasis curative provided in the invention characterized in that it contains ingredient (a) and (b) as following: (a) seed vessel of the blonde psyllium; (b) the following formula (1) represents polyoxyethylene polyoxypropylene glycol. In the formula (1), a+c is between 3 and 200, b is between 5 and 67. HO-(C2H4O)a-(C3H6O)b-(C2H4O)c-H (1).

Description

technical field [0001] The present invention relates to a medicine for treating constipation and a method for producing the same, more specifically, a medicine for treating constipation and a method for producing the same for smoothly discharging waste (stool) remaining in the intestine. Background technique [0002] Detoxification (detox) usually refers to the process of excreting harmful minerals and toxins in the body to purify the body. This detox is carried out by eliminating constipation, taking supplements, fasting, massage, bathing, etc. [0003] Various constipation remedies are used for one of the above-mentioned detoxifications, and in particular, in recent years, ingredients derived from plants have been used with emphasis on health. As such a plant-derived component, the seed coat of Plantago ovata can be mentioned. [0004] The egg-leaf plantain is a plant of the genus Plantago (Plantaginaceae), which is mainly cultivated in the Mediterranean region of Europe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/68A61K36/78A61K36/896A61K36/9066A61P1/10A61K31/08A61K31/77
Inventor 横田昌之望月阳子森阳子神户英芳
Owner SS PHARMA CO LTD