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Cefixime oral administration mixed suspension and preparation method thereof

A technology for oral suspension and cefixime, which is applied in liquid delivery, pharmaceutical formula, emulsion delivery, etc., to achieve good drug compliance, simple preparation method, and solve stability problems

Active Publication Date: 2010-06-09
SINOPHARM ZHIJUN (SHENZHEN) PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The technical effect of this patented technology involves making stable aqua solutions containing ceftimidazole hydrochloride (Cefoxil) without losing flavor over time. This solution makes it easier than other methods like mixing them together because they are ready to use directly from their original container instead of being diluted beforehand. It's convenient to take these liquids at once, especially when young pills have trouble ingesting tablets due to bad smell or difficulty chewing on food. These compositions provide better tastiness compared to traditional ways such as powders or sugar syrups used alone.

Problems solved by technology

The technical problem addressed by this patented technology relates to finding an effective way to administer these types of drug without losing its effectiveness when stored dry up during storage at room temperature (approaching 37°C).

Method used

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  • Cefixime oral administration mixed suspension and preparation method thereof
  • Cefixime oral administration mixed suspension and preparation method thereof
  • Cefixime oral administration mixed suspension and preparation method thereof

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preparation example Construction

[0024] The preparation method of cefixime oral suspension of the present invention, every 100ml of cefixime oral suspension comprises the following steps: one, by the conventional dosage of liquid preparation, methylparaben, ethylparaben, nipagin More than one of propylparaben and butylparaben is dissolved in propylene glycol or / and ethanol; 2. one of povidone K30, povidone K25 and povidone K90 greater than 0 to 20.0g Add more than one kind of liquid maltitol or / and liquid sorbitol, stir to dissolve; three, add more than one of menthol, cherry flavor, strawberry flavor, vanilla flavor, orange flavor and banana flavor, paraben One or more of ester, ethylparaben, propylparaben and butylparaben, mixed with propylene glycol or / and ethanol solution, stirring and mixing evenly; 4. Add 0.5-4.0g cefixime micropowder, liquid maltose Stir and disperse evenly to the required amount of alcohol to obtain cefixime oral suspension; the particle size of the cefixime micropowder is greater tha...

Embodiment 1

[0028] Embodiment 1, preparation 1000ml cefixime oral suspension (5ml: 25mg)

[0029]

[0030]

[0031] Preparation process: Dissolve ethylparaben in propylene glycol and set aside; add povidone K30 to an appropriate amount of maltitol and stir to dissolve, then add strawberry essence and propylene glycol solution of ethylparaben, stir and mix evenly, then add Add cefixime micropowder and maltitol to 1000ml, stir at high speed to disperse evenly, and you get it. The particle size of the cefixime micropowder is greater than 0 to 150 μm, the stirring speed is 1000 rpm, and the stirring time is 20 minutes.

Embodiment 2

[0032] Embodiment 2, preparation 1000ml cefixime oral suspension (5ml: 50mg)

[0033]

[0034] Preparation process: Dissolve ethylparaben in propylene glycol and set aside; add povidone K30 to an appropriate amount of maltitol and stir to dissolve, then add strawberry essence and propylene glycol solution of ethylparaben, stir and mix evenly, then add Add cefixime micropowder and maltitol to 1000ml, stir at high speed to disperse evenly, and you get it. The particle size of the cefixime micropowder is greater than 0 to 120 μm, the stirring speed is 1500 rpm, and the stirring time is 15 minutes.

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Abstract

The invention discloses a cefixime oral administration mixed suspension and a preparation method thereof, in order to meet the requirement of special medicament taking crowds on the taking of cefixime. The cefixime oral administration mixed suspension per 100ml comprises the following components: 0.5-4.0g of cefixime, larger than 0-20.0g of thickening suspension assistant agent, a cosolvent, a flavoring agent, a preservative and the balance of non-aqueous liquid medium. The preparation method comprises the following steps of: dissolving the preservative into the cosolvent; adding the thickening suspension assistant agent into the non-aqueous liquid medium, stirring and dissolving; adding solutions of the flavoring agent, the preservative and the cosolvent uniformly stirring; and adding cefixime micropowder and uniformly stirring and spreading. Compared with the prior art, the unstable cefixime in water is made into the oral administration mixed suspension by using non-aqueous liquid as a dispersing medium, and the invention solves the problem of stability, has good taste and simple preparation method, is convenient for children, old people and a dysphagia patient to accept and is suitable for industrialized production.

Description

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Claims

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Application Information

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Owner SINOPHARM ZHIJUN (SHENZHEN) PHARMA CO LTD
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