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Pharmaceutical composition for promoting blood circulation, removing blood stasis and relieving pain and preparation method thereof

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, non-central analgesics, etc., can solve the problems of prolonged heating time of drugs, difficult hygiene control, long concentration time, etc., to reduce the amount of excipients, solvents, etc. The effect of improving the curative effect with less dosage

Inactive Publication Date: 2010-06-23
四川省中医药科学院中医研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, Panax notoginseng is the monarch drug in the prescription. In the process, the medicinal material of Panax notoginseng is directly powdered into medicine and pressed into tablets, which will increase the dosage; in addition, it is difficult to control the hygiene of raw medicine powder into medicine; The dregs and safflower are decocted twice, the decoction is combined and concentrated, then mixed with Panax notoginseng raw medicine powder to granulate and tablet
When decocting, the amount of solvent is large, the concentration time is long, the heating time of the drug is also prolonged, and the production efficiency is low

Method used

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  • Pharmaceutical composition for promoting blood circulation, removing blood stasis and relieving pain and preparation method thereof
  • Pharmaceutical composition for promoting blood circulation, removing blood stasis and relieving pain and preparation method thereof
  • Pharmaceutical composition for promoting blood circulation, removing blood stasis and relieving pain and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of embodiment 1 medicine of the present invention

[0019] Take 100g of Panax notoginseng, 100g of safflower, and 200g of Chuanxiong Rhizoma Chuanxiong, all of which are extracted by dynamic countercurrent extraction technology. Among them, Panax notoginseng is soaked with 0.9 times of 70% ethanol to the heart, put into a dynamic countercurrent extraction device, and add 8 times the amount of 70% Ethanol 50°C countercurrent extraction, stage extraction time is 40min, the extract is recovered after ethanol for later use; safflower is added with 12 times the amount of water (safflower extracted for the first time is added with 2.6 times of water to make up the water absorption), 60°C countercurrent extraction, The stage extraction time is 30 minutes; Ligusticum chuanxiong is soaked in 1.7 times of water until it penetrates the heart, put into a dynamic countercurrent extraction device, add 10 times of water, and extract in countercurrent at 70 ° C. The stag...

Embodiment 2

[0021] The preparation of embodiment 2 medicinal extracts of the present invention

[0022] Take 100g of Panax notoginseng, 100g of safflower, 200g of Rhizoma Chuanxiong, soak Panax notoginseng with 3 times of 95% ethanol until it penetrates the heart, put it into a dynamic countercurrent extraction device, add 15 times of 95% ethanol for countercurrent extraction at 100°C, and the stage extraction time is 100min , the extract is recovered from ethanol and used for later use; safflower is added with 16 times the amount of water, extracted at 100°C countercurrently, and the stage extraction time is 100 minutes; Ligusticum chuanxiong is soaked in 3 times of water until the heart is penetrated, put into a dynamic countercurrent extraction device and then added 15 times the amount water, 100°C countercurrent extraction, stage extraction time 100min; combined extracts.

[0023] In the extract powder obtained by mixing, concentrating and drying the prepared extracts, the total weigh...

Embodiment 3

[0024] The preparation of embodiment 3 medicinal extracts of the present invention

[0025] Take 100g of Panax notoginseng, 100g of safflower, 200g of Rhizoma Chuanxiong, soak Panax notoginseng in 0.5 times of 30% ethanol until it penetrates the heart, put it into a dynamic countercurrent extraction device, add 3 times of 30% ethanol for countercurrent extraction at 30°C, and extract in stages for 20 minutes , the extract is recovered from ethanol and used for later use; safflower is added with 6 times the amount of water, extracted at 30°C countercurrently, and the stage extraction time is 20 minutes; Ligusticum chuanxiong is soaked in 0.5 times of water until it penetrates the heart, put it into a dynamic countercurrent extraction device, and then add 3 times the amount water, 30 ° C countercurrent extraction, stage extraction time 20min; combined extracts.

[0026] In the extract powder prepared by mixing, concentrating and drying the obtained extract, ginsenoside Rg 1 , G...

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Abstract

The invention relates to a pharmaceutical composition for promoting blood circulation, removing blood stasis and relieving pain, which is a common pharmaceutical medicament prepared by taking 1 part of notoginseng, 2 parts of hemlock parsley and 1 part of safflower in weight percent as raw materials, obtaining extracts by dynamic reverse flow extraction separation, and adding pharmaceutically acceptable adjuvant or auxiliary components, wherein in the extracts, the content in weight percent of ginsenoside Rg1, ginsenoside Rb1 and notoginsenoside R1 is 0.5-12%, the content in weight percent of hydroxysafflor yellow A is 0.1-2%, and the content in weight percent of ferulic acid is 0.01-0.2%. The pharmaceutical composition of the invention is prepared by continuous dynamic reverse flow extraction, has low extraction temperature and small dosage of solvent, reduces damage to effective components caused by the preparation process, and improves the curative effect of the medicament.

Description

technical field [0001] The invention relates to a pharmaceutical composition for promoting blood circulation, removing blood stasis and relieving pain, belonging to the field of medicines. Background technique [0002] Shuxiong Tablets is recorded in the 2005 edition of the "Chinese Pharmacopoeia". It is a traditional Chinese medicine preparation made of three medicinal materials: Panax notoginseng, safflower, and Chuanxiong. It has the effects of promoting blood circulation, removing blood stasis, dredging collaterals and relieving pain. It is clinically used for chest pain and other diseases caused by blood stasis. The prescription dosage is: Sanqi 100g, safflower 100g, and Chuanxiong 200g. The preparation method is: grind the three medicinal materials and Sanqi into fine powder, and sieve; add water to decoct Chuanxiong for 2 hours, filter, and store the filtrate separately. Decoct the flowers with water twice, 1 hour each time, combine the decoction three times, filter,...

Claims

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Application Information

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IPC IPC(8): A61K36/286A61P29/00
Inventor 李希谢守德肖锦冯建安张嵩
Owner 四川省中医药科学院中医研究所