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Subtraction computer body-layer perfusion functional imaging method

A technology of perfusion imaging and functional imaging, applied in echo tomography, computed tomography scanner, etc., can solve the problem of unsuccessful clinical application in diagnosing osteonecrosis, inability to obtain accurate and effective bone ischemia, osteonecrosis physiology, pathological state and other problems. Change evaluation and diagnosis information, etc., to achieve the effect of short scanning and imaging time, expanding application scope, and few influencing factors

Inactive Publication Date: 2010-07-21
上海市第八人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, on CT images, the extremely high density image of bone tissue conceals the changes in local blood perfusion before and after contrast agent injection, and it is impossible to obtain accurate and effective physiological data such as bone ischemia and osteonecrosis using existing CTP technology and software. , pathological state and change evaluation and diagnostic information, making bone CTP a bottleneck in the clinical application of CTP, so far there has been no successful clinical application, especially the report of diagnosis of osteonecrosis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Object: femoral head

[0016] Adopt GE LightSpeed ​​4-slice spiral CT instrument, use cine mode, 80kV, 200mA, matrix 512×512, FOV 12cm, scan 4 slices at the same time every revolution of the tube, scan time is 1s, slice thickness 5mm, scan range 20mm, contrast agent Use 50ml of 300mgI / ml Omnipaque, automatically push injection through the forearm vein high pressure syringe at a rate of 4ml / s, delay for 5s, and scan (data acquisition) for 50s.

[0017] After the scan is completed, the CTP image data is transmitted to the imaging workstation (AW 4.2), and the image data after blood perfusion at the selected femoral head level is firstly compared with the image data of the same level and the same frame, layer by layer according to the perfusion sequence. Subtraction, to generate a new set of subtraction image (data) sequence, and then use the conventional bone perfusion imaging analysis system of Perfusion 3 software to image and analyze the subtraction image (data) sequen...

Embodiment 2

[0019] Target: brain (brain tumor)

[0020] Adopt GE LightSpeed ​​4-slice spiral CT instrument, use cine mode, 80kV, 200mA, matrix 512×512, FOV 12cm, scan 4 slices at the same time every revolution of the tube, scan time is 1s, slice thickness 5mm, scan range 20mm, contrast agent Use 50ml of 300mgI / ml Omnipaque, automatically push injection through the forearm vein high pressure syringe at a rate of 4ml / s, delay for 8s, and scan (data acquisition) for 50s.

[0021] After the scan is completed, the CTP image data is transmitted to the imaging workstation (AW 4.2), and the image data after blood perfusion of the selected brain tumor layer is firstly compared with the image data of the same layer and the same frame, layer by layer according to the perfusion sequence. Subtraction to generate a new set of subtraction image (data) sequence, which is imaged and analyzed in the conventional bone perfusion imaging analysis system using Perfusion 3 software, and the computer automatical...

Embodiment 3

[0023] Object: Brain (cerebral infarction)

[0024] Adopt GE LightSpeed ​​4-slice spiral CT instrument, use cine mode, 80kV, 200mA, matrix 512×512, FOV 25cm, scan 4 slices at the same time every revolution of the tube, scan time is 1s, slice thickness 10mm, scan range 40mm, contrast agent Use 50ml of 300mgI / ml Omnipaque, inject automatically through the forearm vein high pressure syringe at a rate of 4ml / s, delay for 8s, and scan (data acquisition) for 40s.

[0025] After the scan is completed, the CTP image data is transmitted to the imaging workstation (AW 4.2), and the image data after blood perfusion at the selected basal ganglia level is firstly compared with the image data of the same level and the same frame, layer by layer according to the perfusion sequence. Subtraction, to generate a new set of subtraction image (data) sequence, in the conventional brain perfusion imaging analysis system using Perfusion 3 software to image and analyze the subtraction image (data) seq...

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Abstract

The invention provides a subtraction computer body-layer perfusion functional imaging method. The method comprises the following steps: performing single-single or multi-layer dynamic continuous reinforced spiral CT scan on local tissue in order to get image data of each layer of tissue before and after contrast agent blood perfusion; transmitting images to an image workstation; using image subtraction software to create a novel digital image sequence of a group of contrast agent blood perfusion images of protruding tissue; and utilizing CT perfusion imaging (CTP) software of the image workstation to process and analyze the data of the novel digital image sequence in order to produce a group of color level images and values of parameters reflecting tissue blood perfusion states after subtraction. The method has the advantages of economical efficiency, practicability, no need for radioisotope, high image space and time resolution, short scanning and imaging time, few influencing factors, excellent repeatability, wide popularization, low examination cost and the like, and solves the problem that the prior art cannot effectively realize CTP evaluation and non-invasive examination of bone tissue or other high-density tissue and lesions.

Description

technical field [0001] The invention relates to a computer imaging method, in particular to a tissue subtraction computer tomographic perfusion function imaging method. Background technique [0002] Osteonecrosis, such as femoral head necrosis, is a common and frequently-occurring disease. The high incidence rate and the young age of the affected population have brought great harm and challenges to the whole society and human health. Moreover, its prognosis is poor and the harm is great. remains a thorny problem in medicine. Osteonecrosis focuses on early diagnosis, discovery and timely and effective intervention and treatment. However, there is still a lack of an effective means to accurately diagnose early or even ultra-early osteonecrosis. Osteonecrosis due to various reasons always leads to local bone blood supply disorder, which leads to further changes of bone cells such as ischemia, necrosis, bone trabecular fracture, and bone surface collapse. In theory, CT perfus...

Claims

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Application Information

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IPC IPC(8): A61B6/03
CPCA61B6/507
Inventor 杨秀军
Owner 上海市第八人民医院
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