The present invention relates to the field of computer-aided surgery technology and craniomaxillofacial repair and reconstruction surgery medical equipment, in particular to an intraoperative real-time navigation operation method for assisting removal of foreign bodies in the mandibular region, which is characterized by the following steps: preoperatively modulating dental self-curing gum to make mouth opening Fix the guide plate, and then wear the guide plate in the mouth to perform thin-slice spiral CT scanning of the patient’s maxillofacial area, import the CT data into the navigation software i‑plan for preoperative planning, accurately mark the position of foreign bodies and set the approach of clamping instruments; , wearing a mouth opening guide plate for maxillofacial surgery area surface registration and clamping instrument registration, and the navigation operation can be performed after the accuracy is verified to be qualified. After exposing the operation area, follow the planned path and trajectory, observe and adjust the path of the instrument tip in real time on the navigation display, and remove the foreign body. The invention realizes the navigation surgery technique in the movable area of the mandible, the method is convenient, the additional cost is low, easy to learn and use, and the curative effect is stable.