Hydroxyapatite nanotube and preparation and application thereof in bone repair

A technology of hydroxyapatite and nanotubes, applied in the direction of nanostructure manufacturing, nanotechnology, nanotechnology, etc., to achieve the effect of simple process, low cost, and superior biomedical application prospects

Inactive Publication Date: 2010-07-28
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Summarizing the results of literature about the preparation of nano-hydroxyapatite in recent years, it can be found that there is ...

Method used

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  • Hydroxyapatite nanotube and preparation and application thereof in bone repair
  • Hydroxyapatite nanotube and preparation and application thereof in bone repair
  • Hydroxyapatite nanotube and preparation and application thereof in bone repair

Examples

Experimental program
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Embodiment 1

[0037] Dissolve 0.004mol of ammonium dihydrogen phosphate and 0.006mol of calcium chloride in 40ml of water, then add 10ml of ethanol solution containing 0.006mol of octadecylamine, stir for 60 minutes, and transfer the above mixed solution to a stainless steel autoclave , treated at 120° C. for 72 hours, cooled to room temperature after the reaction was complete, and finally centrifuged to obtain a precipitate, which was washed with deionized water and dried to obtain hydroxyapatite nanotubes. The product was identified as hydroxyapatite by X-ray powder diffraction (see figure 1 ), TEM electron microscope inspection product morphology (see figure 2 ).

Embodiment 2

[0039] Dissolve 0.006 mol of sodium dihydrogen phosphate and 0.009 mol of calcium chloride in 40 ml of water, then add 10 ml of decylamine ethanol solution containing 0.01 mol, stir for 60 minutes, transfer the above mixed solution to a stainless steel autoclave, Treat at 110° C. for 48 hours, cool to room temperature after the reaction is complete, and finally centrifuge to obtain a precipitate, which is washed with deionized water and dried to obtain hydroxyapatite nanotubes. The product is identified as hydroxyapatite through X-ray powder diffraction, and the product morphology is detected by TEM electron microscopy (see image 3 ).

Embodiment 3

[0041] Dissolve 0.01 mol of potassium dihydrogen phosphate and 0.015 mol of calcium nitrate in 40 ml of water, then add 10 ml of 0.01 mol of hexadecylamine ethanol solution, stir for 60 minutes, transfer the above mixed solution to a stainless steel autoclave, Treat at 150° C. for 24 hours, cool to room temperature after the reaction is complete, and finally centrifuge to obtain a precipitate, which is washed with deionized water and dried to obtain hydroxyapatite nanotubes. The product is identified as hydroxyapatite through X-ray powder diffraction, and the product morphology is detected by TEM electron microscopy (see Figure 4 ).

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Abstract

The invention discloses a hydroxyapatite nanotube with a diameter of 20-80 nanometers and a length of 1-20 micrometers. The hydroxyapatite nanotube can be prepared under low temperature by taking phosphor source which is cheap and easy to obtain, calcium source and surfactant as the reactants. The preparation method is simple in process, suitable for industrial mass production and low in cost and barely causes pollution to the environment. The hydroxyapatite nanotube is applicable in bone repair or bone grafting. The invention discloses a preparation method of the hydroxyapatite nanotube.

Description

Technical field: [0001] The invention relates to a nano-hydroxyapatite nanotube, a production method thereof and an application in biomedicine. Background technique: [0002] Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ), is the main inorganic mineral component of animal hard tissues such as bones and teeth, and is widely used in biological field of medicine. A large number of biocompatibility tests have proved that synthetic hydroxyapatite is as non-toxic, non-irritating, non-allergic, non-mutagenic, non-hemolytic, non-destructive to biological tissues, and can form with bone Strong chemical combination is a very promising material for artificial bone and artificial oral cavity. [0003] The study found that the artificially synthesized nano-hydroxyapatite powder has a high specific surface area and good adsorption performance. As a new, environmentally friendly and efficient adsorbent, it is widely used in the adsorption and separation of biological proteins, Adsorption ...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82B3/00A61L27/12
Inventor 郭学锋郭向可丁维平
Owner NANJING UNIV
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