Tablet used for treating prostate diseases as well as preparation method and application thereof

A prostate and tablet technology, which is applied in the field of tablet preparation for the treatment of prostate diseases, can solve the problems of difficult to meet the quality standards of pharmaceutical tablets, the shelf life of pharmaceuticals, and unqualified pharmaceutical quality, and achieve moderate hardness and friability. character, the amount of excipients and the effect of small quantity

Active Publication Date: 2010-08-18
贵州太和制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method not only has the disadvantages of long production cycle, complex process, large amount of excipients, large quantity, time-consuming, and energy-consuming, but also has a specific fishy smell that is unacceptable to patients because of the animal medicine hedgehog skin and mole cricket in the formula.
In addition, although there is still some oil left after processing the two-flavor medicinal material, it is highly hydrophobic, which will make it difficult to form a tablet. Even if it is made into a tablet, it also has the disadvantages of slow disintegration and extremely poor friability, and it is difficult to meet the requirements of pharmaceutical tablets. If the quality standard is required, and the storage time is a little long, the oil seeps out to form mottling, which leads to the unqualified quality of the medicine, and it is easy to mildew, and the shelf life of the medicine cannot be reached.

Method used

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  • Tablet used for treating prostate diseases as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 : the preparation method of tablet of the present invention

[0022] The present embodiment is the preparation method of tablet of the present invention, specifically comprises the following steps:

[0023] (1) Take 250 kg of bristle grass and 125 kg of saponins, add 1800 L of water, heat and reflux for extraction for 2 hours, and concentrate the extract to a relative density of 1.20-1.25 (80°C).

[0024] (2) 25 kg of Wang Buliuxing were stir-fried and processed at a temperature of 160-170°C for 5-6 minutes, crushed and passed through a 40-mesh sieve.

[0025] (3) Mix the fine powder of wangbuliuxing with the above-mentioned extract prepared from bristle grass and saponaria thorn, vacuum dry and pulverize, and pass through a 40-mesh sieve to obtain extract powder.

[0026] (4) Processing of mole crickets: Heat the pot with a slow fire, sprinkle 3.75 kg of bran with a mesh size greater than 20, stir fry continuously to generate smoke, add 15 kg of mole cricke...

Embodiment 2

[0031] Example 2 : identification of tablet of the present invention

[0032] Respectively according to the Chinese Pharmacopoeia 2005 Edition 1 Appendix XIIA "Disintegration Time Limit Inspection Method", Chinese Pharmacopoeia 2005 Edition 2 Edition Appendix XG "Tablet Friability Inspection Method", and Chinese Pharmacopoeia 2005 2 Edition Appendix XIXC "Drug Preparation Stability Test Guidelines", the disintegration, friability, and stability of the tablet prepared in the above-mentioned embodiment 1 are tested and investigated, and compared with the tablet made by conventional technology (according to Chinese patent CN1235608C Prepared by the method disclosed in) is carried out comparative test as a contrast, and in fact the results are as follows:

[0033] 1) Disintegration time limit test of tablets

[0034]The test is divided into three groups, and each group takes 6 tablets made by the technology of the present invention. According to the Chinese Pharmacopoeia in 200...

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PUM

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Abstract

The invention provides a tablet used for treating prostate diseases and a preparation method thereof. The preparation method provided by the invention comprises the following steps of: (1) carrying out water extraction and / or alcohol extraction on adiantum capillus-veneris and spina gleditsiae, preferably adding water, refluxing, extracting and concentrating an extracting solution into an extract; (2) after processing vaxxaria seed, pulverizing, mixing with the extract of the adiantum capillus-veneris and the spina gleditsiae, which is prepared in the step (1), and preparing extract powder after drying and pulverizing; (3) after processing, pulverizing and sterilizing mole cricket and hedgehog skin respectively, mixing to obtain the fine powder of the mole cricket and the hedgehog skin and mixing with a coating material to prepare coating particles; and (4) after mixing the extract powder prepared in the step (2) and the coating particles prepared in the step (3) evenly, tabletting. The tablet prepared according to the method has little use quantity and number of auxiliary materials, no abnormal fishiness, quick disintegration, simple production process and short production period, saves the energy effectively, reduces the discharge effectively and lowers the production cost, the friability conforms to the requirement, and a medicine has long shelf life.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy. Specifically, the present invention relates to a method for preparing a tablet for treating prostate diseases and its application. Background technique [0002] Prostate disease is a common male disease, which will affect the normal work and life of the patient if it is serious. The existing treatment method generally adopts oral Chinese medicine or western medicine. [0003] In the Chinese patent CN 1235608C, a traditional Chinese medicine composition developed on the basis of a century-old proven prescription of the Miao nationality in Guizhou, my country is disclosed. It has the effects of clearing dampness and heat, promoting blood circulation and removing blood stasis, diuresis and treating stranguria. It is used to treat prostatitis, benign prostatic hyperplasia and urinary system infection. The preparation method of the traditional Chinese medicine compositio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/483A61K9/20A61K9/30A61P13/08A61P13/00A61P31/00A61K35/64A61K35/36
Inventor 刘伟高爱琴
Owner 贵州太和制药有限公司
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