30 results about "Prostatic mass" patented technology

This invention relates to a non-invasive predictive kit and method for the progression of benign prostatic hyperplasia (BPH) based on prostatic fluid. The invention provides the application of FGF9 as a non-invasive predictive biomarker for the progression of BPH based on prostatic fluid, wherein the concentration of FGF9 in prostatic fluid serves as an indicator of BPH progression. The invention also provides a method for detecting the concentration of FGF9 in prostatic fluid for non-disease diagnostic purposes. Compared with existing technologies, the non-invasive BPH detection method based on prostatic fluid of this invention has advantages such as non-invasiveness, accuracy, simplicity, practicality, and scalability, and is expected to be widely used in the clinical diagnosis and treatment of prostate diseases.

The present application relates to the technical field of stem cell medicine, in particular to a mesenchymal stem cell composition for treating prostate diseases and a preparation method and application thereof. The mesenchymal stem cell composition for treating prostate diseases comprises mesenchymal stem cells treated by low oxygen and an anti-inflammatory peptide WYPWMKKHHRRRRRRRRR. The prostate diseases are selected from prostatitis, prostate calcification, sexual function improvement, frequent urination and urgency, etc. The mesenchymal stem cell composition can significantly improve the symptoms of prostate diseases, and the curative effect is remarkable.

The use of a Morus alba extract in the preparation of a drug for treating and / or preventing prostate diseases. The Morus alba extract contains an alkaloid with a weight content of 3% or more, and / or a polysaccharide with a weight content of no more than 70%, and / or a flavone with a weight content of no more than 10%, and / or an amino acid with a weight content of no more than 50%, and / or other components. The Morus alba extract has a significant therapeutic effect on prostate-related diseases.

The invention discloses a medical biological dressing suppository matrix and a preparation method thereof, and relates to the technical field of suppositories, the medical biological dressing suppository matrix is prepared by taking gelatin, glycerol, polyethylene glycol derivatives and chitosan quaternary ammonium salt as raw materials, the biocompatibility of the suppository matrix is good, and stimulation and anaphylactic reaction cannot be generated on a medication cavity; and after the suppository matrix is dissolved in the cavity, a film with good adhesion can be formed on the mucous membrane of the cavity, so that the released medicine is fully contacted with the focus for a long time, the curative effect and bioavailability of the medicine are improved, and the suppository is suitable for preparing suppositories for treating gynecological diseases, anorectal diseases and prostate diseases.

The invention provides an analysis kit and a detection method of prostate small body leaked protein, and relates to the technical field of kits.The analysis kit comprises a kit body, a heating cavity is formed in the portion, adjacent to the lower portion of a storage groove, in the kit body, and an electric heating piece is fixedly installed on the top face of the inner end of the heating cavity; the microcontroller synchronously starts the failure judgment timing module, if the detection articles are not used within one hour, the module feeds back a signal to enable the microcontroller to control the micro motor to lock the box cover again, and the electric heating sheet in the heating cavity of the box body is started to forcibly discard the reagent, so that the detection error caused by the active failure reagent is prevented; according to the present invention, the accurate detection is ensured through the preparation before the detection and the reagent aging control, and the problems that the accuracy of the detection result is affected due to the lack of the temperature balance control mechanism and the reagent aging control function of the current prostate small body leakage protein detection kit so as to interfere the prostate disease clinical diagnosis and illness state evaluation are solved.

The invention relates to the technical field of stem cell medicines, in particular to a mesenchymal stem cell composition for treating prostate diseases as well as a preparation method and application of the mesenchymal stem cell composition. The mesenchymal stem cell composition for treating the prostate diseases, disclosed by the invention, is prepared from mesenchymal stem cells subjected to hypoxia treatment and an anti-inflammatory peptide WYPWMKKHRRRRRRRR. The prostate diseases are selected from prostatitis, prostate calcification, sexual function improvement, frequent micturition, urgent micturition and the like. The mesenchymal stem cell composition disclosed by the invention can be used for remarkably improving symptoms of prostate diseases and is remarkable in curative effect.

The invention relates to the technical field of medicinal liquor, in particular to medicinal liquor special for treating prostate diseases. 420g to 500g of Chinese yam; 420 g to 500 g of prepared rehmannia root; 420g to 500g of semen euryales; the weight of the cornus officinalis is 450 to 500 grams; 150 g to 180 g of syngnathus; 390-450 g of lotus seeds; and 5000-5500 g of sorghum liquor with the alcohol content of 62%. The medicinal liquor contains effective components of Chinese yam, gordon euryale seed, dogwood, lotus seed, syngnathus and stir-fried Chinese chive seed, 62-degree kaoliang spirit is selected as a solvent, the alcoholic strength is moderate, the effective components in the medicinal materials are fully extracted, the medicinal liquor has a remarkable treatment effect, and related symptoms of prostate diseases can be effectively relieved; after the medicinal liquor is prepared, a patient only needs to take the medicinal liquor according to the specified taking time and dosage, complicated operation or additional treatment equipment is not needed, and the medicinal liquor is suitable for patients with various types of prostate diseases, including prostatitis, prostatic hyperplasia and the like, has a wide application prospect, and has a cure effect of 100%.

The invention belongs to the technical field of food, and discloses endurance sports nutritious food, which is characterized by being prepared from the following raw materials by weight: 3g of raspberry, 1g of fructus lycii, 1g of fructus alpiniae oxyphyllae, 0.1 mg of vitamin B1, 0.1 mg of vitamin B2, 1mg of vitamin E, 0.5 mg of zinc, 0.05 g of stevia rebaudiana, and 0.01 g of edible essence. The traditional Chinese medicine has the effects of tonifying kidney, nourishing blood, protecting ovary and regulating menstruation. The traditional Chinese medicine composition can protect testis, prevent sexual hypofunction and prostate diseases, delay senescence, blacken hair and treat amnesia, tinnitus and hypopsia. And enuresis and dripping are carried out.

The present invention discloses a preparation process and application of a compound preparation of astaxanthin, lycopene and proanthocyanidins for anti-aging and prevention of prostate diseases, belonging to the field of biomedicine. The preparation is composed of astaxanthin (1-10 parts), proanthocyanidins (5-30 parts), lycopene (2-15 parts), black cumin seed oil (0.5-3 parts), Phyllanthus emblica extract (3-8 parts) and Withania somnifera extract (1-5 parts), and is prepared by high-efficiency wet granulation technology. The components act synergistically to significantly enhance antioxidant, anti-inflammatory and anti-cancer activities, and have dual effects of anti-aging and prevention and treatment of prostate diseases. Experiments show that the hydroxyl radical scavenging rate of the compound preparation is 2.3 times higher than that of the single ingredient, the inflammatory factors in the prostatitis model are reduced by 68%, the skin antioxidant capacity is increased by 55%, and the combination with finasteride can reduce the dosage of chemical drugs by 80% and reduce the risk of sexual dysfunction. Black cumin seed oil significantly improves the bioavailability of lycopene (29.7%), and the drug concentration in the prostate tissue reaches 6.5 times that in the blood, achieving high efficiency with low dosage.

The purpose of this invention is to establish a single-particle inductively coupled plasma mass spectrometry (ICP-MS) method for analyzing single magnetic microspheres, which can effectively avoid signal fluctuations caused by errors during absolute quantification, achieving stable and accurate quantification of two prostate cancer biomarkers. The principle of this invention is: using... + Fe 58 The frequency signals of isotopes are used to unify the number of magnetic microspheres, and the results are obtained by evaluating the frequency signals of individual magnetic microspheres. + Au 197 and + Pt 194 The intensity distribution, calculated through average intensity or fitted intensity, yields stable analytical results unaffected by changes in the number of magnetic microspheres detected. This is achieved using the intensity distribution on a single magnetic microsphere. + Au 197 and + Pt 194 The linear relationship between intensity and tPSA and fPSA demonstrates that this analytical method enables the simultaneous detection of two prostate cancer biomarkers and can be applied to the simultaneous analysis of the concentrations of the two biomarkers in the serum of patients with prostate disease.

The invention relates to the technical field of urinary system disease diagnosis, in particular to a prostate tumor onset risk prediction method and system. By combining multiple groups of indexes and image group feature data, the prostate diseases, especially the prostate tumors, can be effectively evaluated, score data reflecting the state of the prostate tumors can be obtained, and the incidence probability and the staging result degree of the endometrial diseases can be more intuitively determined through the score data. Therefore, the overall automatic prediction of the prostate disease is realized.

The invention discloses a bispecific antibody-UC-MSCs preparation for targeting prostate diseases as well as preparation and application of the bispecific antibody-UC-MSCs preparation. The preparation comprises a bispecific antibody BsAb-1 and human umbilical cord mesenchymal stem cells (UC-MSCs), the BsAb-1 is formed by connecting an anti-CD105 single-domain antibody, an anti-PSCA single-domain antibody and a flexible peptide linker in series, wherein the amino acid sequence of the BsAb-1 is as shown in SEQ ID NO: 4. According to the preparation, the UC-MSCs are delivered to a prostate focus through the targeting bridge effect of BsAb-1, the focus enrichment amount within 72 hours is increased by 6.3 times compared with that of pure UC-MSCs, and meanwhile retention of non-target organs such as the liver and the spleen is reduced. The preparation can effectively relieve inflammatory response and fibrosis of chronic prostatitis, and the curative effect of the preparation is remarkably superior to that of pure UC-MSCs treatment. Precise targeted treatment of prostate diseases is achieved, the curative effect is remarkably better than that of a traditional stem cell therapy method, and high clinical application value is achieved.

The invention provides a prostate small body leaked protein detection kit for early screening of prostate diseases, and relates to the technical field of detection kits. A moving frame is installed at the left end of the base in a threaded mode, an electric telescopic rod and an optical probe are fixedly installed at the outer end of the moving frame, an electromagnetic head is fixedly installed at the bottom of the electric telescopic rod, and a set of protective covers are slidably installed at the right end of the base; through cooperation of the limiting block and the elastic piece, rapid dismounting and accurate positioning of the detection disc are realized, and the detection disc can rapidly rotate to switch functional subareas. The moving frame is driven by the motor to link the electromagnetic head and the optical probe to complete the whole process of sample adsorption, cleaning and detection; the protective cover is quickly opened and closed through the sliding design of the elastic piece, and the detection protective performance is effectively improved; the problems that the detection precision and the service life of equipment are affected due to the fact that the detection disc of the detection box is complex in installation structure and tedious in disassembly and assembly process are solved; and a sample processing flow in a detection process lacks an effective partition isolation and automatic control mechanism.

1. The name of this design product: USB flash drive (Commemorative Edition of the Integrated Prostate Disease Diagnosis and Treatment Center). 2. Purpose of this design product: used for quick access to data. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

This invention relates to the field of in vitro diagnostics, and particularly to a combined diagnostic kit for prostate diseases. The invention provides reagents including pH, peroxidase, elastase, lecithin bodies, citric acid, zinc, and acid phosphatase under mild reaction conditions, enabling rapid differentiation of inflammatory and non-inflammatory prostatitis, benign prostatic hyperplasia, and non-prostatic genital tract infections using a single test card. Through extensive experimentation, this invention has developed a one-step reaction scheme suitable for the dry chemical determination of acid phosphatase and lecithin bodies in seminal plasma. This method eliminates the need for a stop solution, achieving a one-step reaction under mild conditions that will not cause damage to operators or fully automated instruments. The samples used are seminal plasma or semen, allowing for large sample volumes and easy acquisition, significantly improving diagnostic efficiency for doctors and patient comfort.

The invention relates to application of a mulberry extract in preparation of a medicine for treating and / or preventing prostate diseases. The mulberry extract comprises alkaloid with the weight content being 3% or above, and / or polysaccharide with the weight content being not higher than 70%, and / or flavone with the weight content being not higher than 10%, and / or amino acid with the weight content being not higher than 50%, and / or other components. The mulberry extract has a remarkable treatment effect on prostate related diseases.

The present invention discloses a method, device and storage medium for detecting prostate lesion regions, which relates to the field of computer vision. Accurate automatic segmentation of prostate lesion regions is an important requirement for computer-aided diagnosis and treatment of prostate diseases. However, there is a lack of clear boundaries and high contrast between the prostate and surrounding tissues, making it difficult to accurately extract the prostate from the background. Due to the scarcity of information in medical images, multiple methods must be used for multi-dimensional information extraction, but the current methods cannot fully learn and mine hidden information. To address the above challenges, the present invention proposes a brand-new method, device and storage medium for detecting prostate lesion regions applicable to the field of computer vision. In order to improve the quality of information extraction at different scales, different convolution combinations and various attention mechanisms are used in the proposed network, enabling it to have superior performance under different imaging modalities.

The invention relates to the technical field of prostate, and discloses a prostate adjuvant therapy system and device.The prostate adjuvant therapy system comprises a needle cylinder, a bottom plate fixedly connected with the needle cylinder, a sealing sliding piece arranged in the needle cylinder in a sliding mode, a push handle connected with the sealing sliding piece, and an electric cylinder fixedly arranged at one end of the bottom plate; an output shaft of the electric cylinder is connected with the push handle; a metal tube is fixedly connected in the needle cylinder through a support, a heating inductance coil is fixedly wound at the outer side end of the metal tube, a filling through tube is connected with the metal tube in a penetrating mode, the filling through tube penetrates through the side wall of the needle cylinder, and the heating inductance coil penetrates through the side wall of the needle cylinder and is connected with a heating device. And a filling funnel is arranged at the top end of the filling through pipe in a manner of penetrating through the filling through pipe. Sealing plates are arranged at the two ends of the metal pipe in a sealed mode. The system is simple to operate, has the advantage of universal and accurate treatment of prostate diseases, and can accurately deliver treatment drugs to prostate lesions.

The invention relates to the technical field of traditional Chinese medicine, in particular to application of a traditional Chinese medicine composition in preparation of a medicine for treating prostate diseases. The traditional Chinese medicine composition takes prepared rehmannia root and poria cocos as main medicines, can assist spleen transportation and transformation to insulate a source of phlegm and can also remove dampness and turbidity to directly relieve dysuria, meanwhile, the dampness removing property of the traditional Chinese medicine composition can restrict greasy taste of the prepared rehmannia root, and the effect of treating prostate diseases is achieved. Cistanche deserticola, astragalus mongholicus and ginseng are used as auxiliary medicines to tonify yin and yang and provide motive power for lower-jiao gasification, astragalus mongholicus and ginseng greatly tonify primordial qi, invigorate the spleen, benefit qi and strengthen the postnatal root, and maca is used as auxiliary medicines to enhance the overall function. According to the traditional Chinese medicine composition, all the medicines are compatible to jointly achieve the effects of tonifying kidney and spleen to consolidate foundation, promoting diuresis and reducing phlegm, and activating blood circulation and eliminating diseases to treat symptoms, the prostate volume is effectively reduced, the urination symptom is improved and the purpose of treating prostatic hyperplasia is achieved by improving the lower-jiao gasification function, promoting water metabolism and softening and dissipating prostate phlegm and blood stasis diseases, and the traditional Chinese medicine composition attacks pathogens without hurting vital energy, tonifies deficiency without lingering pathogens and has no toxic or side effect. And specimens are considered.

The invention relates to the technical field of traditional Chinese medicine navel patches, and particularly discloses a patch formula for prostate treatment and a preparation process. The patch comprises rhizoma smilacis glabrae, flos carthami, rhizoma corydalis, plantain herb, herba patriniae, oxalis corniculata, oldenlandia diffusa, hibiscus mutabilis, borneol and menthol, and houttuynia cordata can also be added. The preparation method comprises the following steps: firstly, mixing part of medicinal materials, carrying out alcohol extraction twice, then carrying out water extraction, combining extracting solutions, and concentrating into extract; heating and melting the bionic polymerized gel, adding the extract, borneol and menthol, stirring, and finally coating on a base material for forming. The patch can be used for treating prostate diseases, and has the advantages that the transdermal delivery efficiency of active ingredients is high, the active ingredients can be effectively accumulated in prostate tissues, the anti-inflammatory effect is good, and the improvement rate of urinary tract symptoms can be increased; in addition, the preparation method has the advantages that active ingredients of the medicinal materials can be fully extracted, the process is stable, and industrial production is facilitated.

The present invention belongs to the field of biomedicine and specifically relates to an umbilical cord mesenchymal stem cell preparation and its use in treating prostate diseases. This preparation, which utilizes 3rd to 6th generation umbilical cord mesenchymal stem cells and neurofilament peptide as active ingredients, along with pharmaceutically acceptable excipients, can significantly reduce the prostate index, PACP, and SRD5A2 concentrations, demonstrating significant therapeutic efficacy in treating prostate hyperplasia. Furthermore, the 3rd to 6th generation umbilical cord mesenchymal stem cells and neurofilament peptide complement each other, creating a synergistic effect that yields significant improvements.

The present invention relates to a composition comprising a mixture comprising or, alternatively, consisting of i) an extract of Gastrodia elata and ii) at least one ingredient selected from the group comprising or, alternatively, consisting of a coenzyme Q10, plant extracts and preparations (so-called botanicals) and / or mixtures thereof. Said mixture comprising or, alternatively, consisting of i) an extract of Gastrodia elata and iia) a coenzyme Q10. Furthermore, the present invention relates to said mixture and the composition containing it for use in the treatment and / or prevention of prostate diseases and / or disorders, in particular benign prostatic hyperplasia (BPH), LUTS (lower urinary tract symptoms) due to BPH, inflammation, preferably inflammation due to BPH, and / or other functional disorders affecting the urinary tract, bladder, testicles and prostate.

The invention provides an automatic prostate pathology reporting system and method based on artificial intelligence, and the system comprises an image obtaining module which is used for obtaining a section image of a prostate; the image segmentation module is used for splitting and extracting the section image of the prostate; the feature extraction module is used for performing feature extraction on the tissue image; the Gleason model module is used for constructing a Gleason scoring model and inputting the first feature data into the Gleason scoring model for training and tuning; the Gleason scoring module is used for inputting the slice image to be analyzed into the optimal Gleason scoring model for scoring; and the report generation module is used for generating a pathological report based on the Gleason score of the slice image to be analyzed. The prostate pathology report is automatically generated through artificial intelligence, and diagnosis and treatment of patients about prostate diseases are greatly improved. And meanwhile, by combining a medical knowledge database and an artificial intelligence technology, better technical support is provided for doctors, and the doctors can make an optimal treatment scheme conveniently.

The present invention relates to a composition comprising sestrin 2 for preventing or treating prostate diseases. Specifically, it has been identified that prostate diseases are inhibited by reducing the size, weight, or epithelial thickness of the prostate in an animal model in which prostate diseases are induced, and thus prostate diseases can be treated or prevented and urination disorders caused by prostate diseases can be alleviated.

The invention discloses a preparation method and application of prostate lineage progenitor cells obtained by multi-stage induction of human induced pluripotent stem cells. The method comprises the following steps: sequentially inducing to form a definitive endoderm, a posterior intestinal urogenital sinus progenitor cell and a prostate progenitor cell, and at the third stage, adopting a collaborative regulation system in which LDN193189 and CHIR99021 are simultaneously added, so that the lineage specialization efficiency and the cell amplification capacity are remarkably improved. And further sorting through a CD49f high-expression membrane marker combination, a Trop2 positive membrane marker combination, a CD26 low-expression membrane marker combination and a CD117 negative membrane marker combination, so that a cell population with high purity, low heterogeneity and immunoregulation potential can be obtained. The cell can reconstruct a gland structure and secrete prostate specific protein in an animal model, and meanwhile, the inflammatory microenvironment is improved through immune tolerance related pathways. The process can realize batch production and maintain product activity and stability, and is suitable for treating chronic prostatitis, postoperative tissue defect, dysfunction and other diseases.

The present invention relates to a use of Copaifera oleoresin to prevent and / or treat prostate pathologies, including benign prostatic hyperplasia or prostate cancer.

The disclosure relates to compositions and methods for rAAV-mediated delivery of a transgene to a subject. In some embodiments, the rAAV transduces the prostate tissue of a subject. In some embodiments, the methods are useful for treatment of prostate disease (e.g., prostatitis, BPH, prostate cancer).

The present invention discloses a traditional Chinese medicine directional transdermal instrument, which comprises a box body, a liquid medicine placer and a soaking container. A waste liquid collection device is arranged at the bottom inside the box body. Placing plates are fixed on the opposite side walls inside the box body. A double-headed pump is installed on one side of the upper end of the placing plate. A delivery pipe is connected to the double-headed pump. A four-way valve is arranged inside the box body. One end of the delivery pipe is connected to the four-way valve. A waste liquid collector is installed on the placing plate. The present invention achieves the purpose of soaking the private parts of male patients with traditional Chinese medicine, promotes blood circulation, activates cells, accelerates the excretion of waste and harmful substances in cells, effectively eliminates bacteria, thereby protecting the prostate of men, reducing the occurrence of prostate diseases. When treating male venereal diseases, the role of the liquid medicine can be fully exerted, and directional and precise drug delivery promotes the full and rapid absorption of the liquid medicine, directly reaches the focus, quickly solves the embarrassing problems of patients, and improves the treatment effect.

According to the application of the flibaserin and the derivative thereof in preparing the medicine for resisting the prostate diseases, the flibaserin serves as a treatment medicine, proliferation of prostate cancer cells can be inhibited, growth of in-vivo tumors can be inhibited, on the premise of low toxic and side effects, the progress of castration-resistant prostate cancer can be relieved, and the prostate diseases can be prevented. Prostatic hyperplasia and prostatic hyperplasia are reduced; the method plays an important role in prolonging the lifetime of a patient and slowing down proliferation, migration and invasion of diseases.

The invention discloses a preparation method of medical biological hydrogel for treating prostate diseases. The preparation method is specifically implemented according to the following steps: step 1, preparing MXene; step 2, preparing ibuprofen-chitosan-gellan gum (ibuprofen-chitosan-gellan gum); and step 3, mixing the MXene in the step 1 with the ibuprofen-chitosan-gellan gum in the step 2 to prepare the MXene-ibuprofen-chitosan-gellan gum. The invention also discloses the biological hydrogel prepared by the method. The MXene serving as a novel material is widely applied to the field of medicine, has good biocompatibility, antibacterial property and photothermal conversion capacity, is loaded with chitosan-ibuprofen, is good in skin permeability, can give full play to the pharmacodynamic effect, and has good application prospects. The traditional Chinese medicine composition can be widely used for treating chronic prostatitis, benign prostatic hyperplasia and frequent micturition, urgent micturition and dysuria symptoms caused by other reasons.