Medicament for treating digestive tract side effects caused by cancer chemotherapy

A technology for digestive tract and side effects, applied in the field of traditional Chinese medicine, can solve the problems such as the lack of Chinese patent medicines that have not yet entered the system development stage, and achieve the effects of reducing animal toxic and side effects, delaying the occurrence of vomiting, and reducing the number of vomiting.

Inactive Publication Date: 2010-09-15
辽宁省中医药研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Li Shangwen and others from the Third People's Hospital of Datong City have also achieved certain results in the treatment of cisplatin-induced gastrointestinal toxicity with modified Evodia decoction, but these studies are only at the level of clinical experience and have not yet entered th

Method used

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  • Medicament for treating digestive tract side effects caused by cancer chemotherapy
  • Medicament for treating digestive tract side effects caused by cancer chemotherapy
  • Medicament for treating digestive tract side effects caused by cancer chemotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The original medicinal materials include: Astragalus 700g, Ophiopogon 260g, Red ginseng 230g, Atractylodes macrocephala 250g, Poria 200g, Licorice 220g, Scrophulariaceae 230g, Ebony 300g, Curcuma 250g, Angelica 200g, Agastache 220g, Tangerine peel 230g, French Pinellia 300g.

[0011] Effect on the phagocytic function of mouse macrophages: 50 mice weighing 18-22 grams, half male and half female, were randomly divided into blank control group, high, medium and low dose groups and Shenqi tablets group, each group of mice Gavage according to the dosage in Table 1, once a day for 7 consecutive days. The blank control group was given the same volume of distilled water, 1 hour after the last administration, according to the literature According to the method described in the method, the mice were injected with 5% chicken erythrocyte normal saline suspension 0.5ml / mouse, 3 hours later, the cervical spine was pulled to kill the mouse, the back was fixed, and 2ml / mouse normal saline ...

Embodiment 2

[0034] The original medicinal materials include: Astragalus 750g, Ophiopogon 280g, Red ginseng 250g, Atractylodes macrocephala 200g, Poria 220g, Licorice 230g, Scrophulariaceae 250g, Black plum 250g, Curcuma turmeric 200g, Angelica 220g, Agastache 230g, Tangerine peel 250g, French pinellia 250g.

[0035] Effect on the toxicity and side effects of cyclophosphamide in mice: Take 60 mice weighing 18-22g, male and female, and randomly divided into model control group, high, medium and low dose groups, cyclophosphamide group and Shenqi tablets group. Except for the cyclophosphamide group, each group was administered intragastrically according to the dosage in Table 5, once a day for 7 consecutive days. The model control group was given the same volume of distilled water. From the 5th day of administration, except for the model control group, the cyclophosphamide group and each administration group were intraperitoneally injected with cyclophosphamide injection at a dose of 100 mg / kg / d...

Embodiment 3

[0059] The original medicinal materials include: Astragalus 770g, Ophiopogon japonicus 7300g, Red ginseng 200g, Atractylodes macrocephala 220g, Poria 230g, Licorice 250g, Scrophulariaceae 200g, Ebony 280g, Curcuma turmeric 220g, Angelica 230g, Agastache 200~250g, Tangerine peel 200g, French pinellia 260g.

[0060] To S 180 Experiment on the effect of tumor weight on mice: Take 50 mice weighing 18-22g, half male and half, under aseptic conditions, routinely inoculate S under the armpit of the right forelimb of the mice. 180 Mouse abdominal cavity tumor fluid 0.2ml / mouse, on the second day after inoculation, randomly divided into high, medium and low dose groups, Shenqi tablets group and model control group according to body weight. The mice in each group were given intragastric administration according to the dosage in Table 9, once a day for 7 consecutive days. The model control group was given the same volume of distilled water. The mice were killed and weighed the next day afte...

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Abstract

The invention provides a medicament for treating digestive tract side effects caused by cancer chemotherapy, comprising the following medical materials: 700-800g of astragalus, 250-300g of dwarf lilyturf root, 200-250g of red ginseng, 200-250g of atractylodes, 200-250g of poria cocos, 200-250g of liquorice, 200-250g of figwort, 250-350g of dark plum, 200-250g of zedoary turmeric, 200-250g of angelica sinensis, 200-250g of ageratum, 200-250g of tangerine peel, and 250-350g of prepared pinellia tuber. The medicament for treating digestive tract side effects caused by cancer chemotherap obviously relieves vomiting response caused by copper sulfate and cisplatin, reduces the time of vomiting, delays vomiting generation, has remarkable function of reducing animal toxic side effects caused by anticancer drugs, and can improve the body immunity.

Description

Technical field [0001] The present invention relates to Chinese medicine. Background technique [0002] Western medicine solves this problem by applying some preparations to increase immunity and antiemetic drugs. It is generally believed that most anti-malignant drugs pass through the blood and cerebrospinal fluid as prototypes or their metabolites to stimulate the chemoemetic receptor area of ​​the fourth ventricle of the brain, thereby causing the excitement of the vomiting center and producing vomiting. In addition, some drugs cause vomiting through peripheral nerves, such as the stimulation of the gastrointestinal tract. [0003] Chemical drugs currently used to prevent and treat the side effects of gastrointestinal tract caused by anti-tumor drugs mainly include ①DA receptor antagonists: such as phenothiazine butyryl benzenes. These drugs mainly act on the chemoemetic receptor area of ​​the fourth ventricle of the brain and peripheral nerves. The DA receptors are effective ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P1/00A61P1/08
Inventor 史常永尤献民贾冬王玉琢
Owner 辽宁省中医药研究院
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