1,4-naphthoquinone compounds and application thereof

Abstract

The invention provides 1,4-naphthoquinone compounds with a formula II, and the definition of substituents of the naphthoquinone compounds are described as the specification. The compounds have the connecting ring structures of piperazine or piperidine, have notable antitumor activity, and provide a new choice for preparing antitumor drugs in clinical practice.

Description

technical field The invention relates to a class of 1,4-naphthoquinone compounds and applications thereof. Background technique Worldwide, the cost of new drug research and development is increasing year by year, but the number of new drugs on the market is decreasing, and the efficiency of new drug research and development is decreasing year by year. In recent years, the number of new drugs approved by countries around the world has shown a new "trough" in the past 20 years. The process of drug innovation is very complicated. First, the development cycle of new drugs is long. It usually takes 10 to 15 years from the synthesis of active compounds to the launch of drugs. Second, the investment in new drug research and development is large. In the United States, it takes about 8 Thirdly, the success rate of new drug research and development is low. Of the 10,000 compounds with in vitro activity synthesized, only 250 can enter animal experiments, only 5 can enter clinical tri...

AI Technical Summary

Problems solved by technology

Shikonin compounds are a class of natural naphthoquinone compounds that widely exist in nature and have significant antitumor activity, but their clinical application is limited due to the toxicity and poor water solubility of these compounds

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