80 results about "1,4-Naphthoquinone" patented technology

The invention relates to a cyanide-free silver plating solution additive which comprises the following components by ratio: 0.1-10g/ l of brightener, 5-10g/ l of leveling agent, 100-600g/ l of complexing agent and the balance of plasma water, wherein the brightener is one or mixture of more in nitrogen-containing compound, triazole, benzotriazole, 2-hydroxypyridine, pyridine, 22 dipyridyl, 1, 10-phenanthroline, triethylene tetramine and diethylene triamine according to any ratio; the leveling agent is one or mixture of more in aromatic hydrocarbon compounds, naphthalene, 1-methylnaphthalene, 1, 4-naphthoquinone and 1-naphthol according to any ratio; the complexing agent is one or mixture of more in disodium ethylenediamine tetraacetate, niacin, aminosulfonic acid and potassium pyrophosphate according to any ratio. The cyanide-free silver plating solution additive has the beneficial effects that the plating solution is stable, low in toxicity and good in dispersing ability; the obtained plating layer is bright and fine as well as good in binding force; the technology adopts the environment-friendly organic additive which does not contain heavy metal and sulfide; the plating layer is good in corrosion resistance. Furthermore, the cyanide-free silver plating solution additive can be directly used for parts such as brass, copper, chemical nickel and the like, preplating is not needed, and the binding force is also guaranteed.

The invention relates to a novel synthesis method of 2-methyl-1,4-naphthoquinone. The novel synthesis method comprises the steps: respectively dissolving a defined amount of 2-methylnaphthalene and metachloroperbenzoic acid in moderate glacial acetic acid to prepare solutions (1) and (2), dropwise adding the solution (2) in the solution (1) under the stirring, after reacting for a period of time at a certain temperature, extracting a reaction solution by using chloroform, washing an extraction solution with a saturated NaHCO3 solution and water, after anhydrous Na2SO4 is dried, performing reduced pressure distillation to prepare a crude product of the 2-methyl-1,4-naphthoquinone, and recrystalizing by using alcohol as a solvent to obtain a pure product of the 2-methyl-1,4-naphthoquinone. According to the novel synthesis method, the conversion rate of the 2-methylnaphthalene can reach 80 percent, and the yield of the 2-methyl-1,4-naphthoquinone can reach 31 percent. The method disclosed by the invention has the characteristics of short reaction time, mild conditions, and the like, and products are easily separated; and no any catalyst is used in the reaction, thus the energy consumption and the environment pollution can be reduced.

It is an object to provide a non-aqueous electrolyte for use in a primary battery, which is advantageous in that the primary battery using the non-aqueous electrolyte suffers less lowering of voltage during the high-rate discharge and can work stably. Disclosed are a non-aqueous electrolyte for use in a primary battery, comprising at least one organic compound selected from the group consisting of 1,2-benzoquinone, 1,4-naphthoquinone, 1,2-naphthoquinone, 9,10-anthraquinone, 1,4-anthraquinone, acenaphthenequinone, and a derivative of 1,2-benzoquinone, 1,4-naphthoquinone, 1,2-naphthoquinone, 9,10-anthraquinone, 1,4-anthraquinone, acenaphthenequinone, or 1,4-benzoquinone; a non-aqueous electrolyte for use in a primary battery, comprising an organic compound exhibiting a reduction potential of 2.5 V or higher and a quantity of electricity in reduction reaction per electrode area of 1,000 mC/cm² or lower under specific conditions; and a non-aqueous electrolyte for use in a primary battery, having a reduction potential of 2.5 V or higher and a quantity of electricity in reduction reaction per electrode area of 1,000 mC/cm² or lower.

The invention relates to a preparation method of a bi-component coating unsaturated polyester resin. The preparation method comprises the following steps of putting reactants and a first polymerization inhibitor accounting for 250 ppm-320 ppm of a total mass of the resin into a container to carry out polycondensation and dehydration reaction, wherein the reactants comprise a dihydric alcohol, allyl ether and unsaturated dicarboxylic acid or anhydride; cooling to a temperature of 120 DEG C-140 DEG C; adding the first polymerization inhibitor accounting for 40 ppm-80 ppm of the total mass of the resin; diluting by adding styrene; cooling to the temperature of 40-60 DEG C; and adding a second polymerization inhibitor accounting for 40 ppm-80 ppm of the total mass of the resin, wherein the second polymerization inhibitor is one or two of 1,4-naphthoquinone and p-benzoquinone. The bi-component coating unsaturated polyester resin prepared by the preparation method has a long resin activation period after an initiator is added; a drying time after the resin added with an accelerant and a resin added with the initiator are mixed is relatively short; and film-forming quality is high.

Aromatic ketones having an extended fluoro-alkyl or fluoro-alkoxy moiety are disclosed. In particular aspects, the compounds comprise substituted 9-acridone, 9-xanthone, 4(1H)-quinolone, 4(1H) pyridone, 1,4-naphthoquinone, 9,10-anthraquinone derivatives. These preparations possess potent pharmacological activity for inhibiting malaria and mosquito-borne (Plasmodium) diseases. The haloalkyl/alkoxy aromatic compounds possess significant pharmacological activity, with IC₅₀ values in the nanomolar and sub-nanomolar range, and reduced toxicity against host derived cells and tissues. Methods of using the fluoro-alkyl/alkoxy aromatic compounds in the treatment of malaria and other human and animal diseases are also disclosed. Agricultural uses of the fluoro-alkyl/alkoxy aromatic compounds, such as in control of fungal diseases and in the production of important commercial crops (apples, etc.), are also presented.

The invention discloses a method for synthesizing vitamin K1, relating to the field of synthesis of organics. The method comprises the following steps: reducing 2-methyl1,4-naphthalenediol in a certain solvent in the presence of a reducing agent under certain conditions to generate 2-methyl-1,4-hydronaphthoquinone; then, adding pohytol and reacting under certain conditions in the presence of a proper catalyst to synthesize 2-methyl3-phytyl1,4-naphthalenediol; oxidizing with a proper oxidizing agent to generate vitamin K1; and carrying out vacuum concentration to obtain finished vitamin K1. When the method is used for synthesizing vitamin K1, 2-methyl1,4-naphthoquinone is used as a raw material, no hydroxyl group protection is needed. Therefore, the method disclosed by the invention has the characteristics of simple process, mild reaction conditions, high yield, high product purity and high product yield; and in addition, the production cost is low, and therefore the method is very suitable for industrial production.

The invention provides 7-(4-chlorphenyl)-5,6-dihydro-7aH-benzo[h]1,2,4-triazolo[3,4-b]quinazoline-5,6-diketone and a synthetic method thereof. The method comprises the following steps of: uniformly mixing 3-amino-1,2,4-triazole, p-chlorobenzaldehyde, 2-hydroxyl-1,4-naphthaquinone and p-methylbenzene sulfonic acid with a usage amount of catalyst, heating and stirring, controlling the temperature at 110-125 DEG C and reacting for 2.5-3 hours. The 7-(4-chlorphenyl)5,6-dihydro-7aH-benzo[h]1,2,4-triazolo[3,4-b]quinazoline-5,6-diketone prepared according to the invention introduces chlorine atoms, thus having stronger activity and being more beneficial to absorption. The method provided by the invention is green and environment-friendly, and has the characteristics that the raw materials are available, the operation is simple and the yield is high.

The invention uses naphthoquinone, amine and mercaptan as raw materials, and provides a preparation method of a thiamine 1,4-naphthoquinone compound. The synthesis method has mild reaction conditions,oxygen is used as an oxidant under the condition of copper catalysis, and multiple thiamine 1,4-naphthoquinone compounds can be synthesized through a one-step reaction, and thus the method provides an efficient and practical synthesis method which is simple, convenient and efficient, cheap and easily-available in raw materials and catalysts, wide in adaptability, and has good application value and market prospect.

The invention discloses a preparation method of atovaquone, and belongs to the drug synthesis field. The method comprises the following steps: condensing alpha-naphthol and 4-(4-chlorophenyl)cyclohexanol under acid catalysis to obtain 2-(4-(4-chlorophenyl)cyclohexyl)-1-naphthol (formula V), oxidizing the compound represented by formula V to obtain 2-(4-(4-chlorophenyl)cyclohexyl)-1,4-naphthoquinone (formula IV), enabling the compound represented by the formula IV to react with bromine in additive reaction to obtain 2,3-dibromo-2-(4-(4-chlorophenyl)cyclohexyl)-1,4-naphthoquinone (formula III), releasing a molecule of hydrogen bromide to obtain 3-bromo-2-(4-(4-chlorophenyl)cyclohexyl)-1,4-naphthoquinone (formula II), hydrolyzing to obtain the atovaquone (formula I). Compared with the prior art, the method disclosed by the invention is simple in process, the expensive silver nitrate is prevented from using in the preparation process; and meanwhile, the yield is improved, the pollution to the environment is reduced, and the method has good popularization and application value.

The invention provides a 2-(3-amino-2-oxoindolin-3-yl)-3-hydroxyl-1,4-naphthoquinone derivative and a preparation method thereof, and belongs to the technical field of compound synthesis. The preparation method comprises the following steps: dissolving isatin derivative as shown in the formula (I), 2-hydroxyl-1,4-naphthoquinone as shown in the formula (II) and an ammonia source as shown in the formula (III) in a solvent; sufficiently stirring to react under a reflux state; tracking by TLC (thin layer chromatography) until the raw materials are completely reacted; cooling, performing suction filtering, and baking to obtain the target product. The preparation method has the advantages of mild reacting condition, simple operation, convenience in post-treatment and high yield which is over 98 percent at most and the melting range of the prepared product is short; the structures of corresponding compounds are certified by IR (infrared radiation), 1HNMR (1H nuclear magnetic resonance), 12CNMR (12C nuclear magnetic resonance) and ESI-MS (electrospray ionization mass spectrometry), and monocrystal can be cultured by a part of target products.

The invention relates to a method for preparing 2-methyl-1,4-naphthoquinone through microwave radiation. The 2-methyl-1,4-naphthoquinone is prepared from beta-methylnaphthalene in a solvent acetate acid gracial under the action of microwave radiation with a polystyrene type polymeric peroxy acid as an oxidant, and the yield reaches 65.0% or above. Microwave radiation heating is adopted, so the reaction time is obviously shortened, and the product yield is improved; and the polymeric peroxy acid oxidant is adopted, so the method has the advantages of high product yield, convenient post-treatment , avoiding of heavy metal pollution of chromium salt oxidants, environmental protection, and important application values.

The invention discloses a preparation method of 2-hydroxy-1, 4-naphthoquinone, which is characterized by mixing naphthol and hydroxide, taking metal phthalocyanine dissolved by hydrophobic ionic liquid as catalyst to have oxygenic reaction, and leaching and drying the reactant to prepare 2-hydroxy-1, 4-naphthoquinone. Compared with the prior art, the invention has simple synthesis process, low cost and easy taking of raw material, low reaction cost and high yield, and the catalyst can be recycled to used and can not pollute environment.

The invention provides a method for preparing vitamin K3, and relates to vitamin K3. The method for preparing vitamin K3 with the chemical name of 2-methyl-1,4-naphthoquinone includes the following steps: dissolving 2-methylnaphthalene into a hydrocarbon solvent; adding sodium dodecyl sulfate and chromium ion oxidation liquid for an oxidation reaction; after completion of the reaction, purifying the reaction solution to obtain vitamin K3 with the chemical name of 2-methyl-1,4-naphthoquinone. The method for preparing vitamin K3 with the chemical name of 2-methyl-1,4-naphthoquinone sodium bisulfate includes the following steps: dissolving 2-methyl-1,4-naphthoquinone into a mixed solvent of water and ethyl alcohol; then adding sodium bisulfite for a sulfonation reaction; after completion of the reaction, purifying the reaction solution to obtain vitamin K3 with the chemical name of 2-methyl-1,4-naphthoquinone sodium bisulfate. According to the invention, the method is high in reaction selectivity, mild in reaction conditions, short in operation steps, green and environment-friendly, and stable in process; the product purity is 97% or above, and the total yield is 79% or above.

The corrosion of unprotected steel substrates causes damage that is costly to repair or replace. Current protective coatings predominately rely on environmentally harmful anticorrosive agents and toxic solvents to protect the underlying substrate. The use of lawsone (2-hydroxy-1,4-napthoquinone) together with a environmentally benign epoxy coating provides an environmentally-friendly alternative for common protective coatings. Microencapsulated lawsone embedded coatings allows the anticorrosive agent to remain dormant until released by damage and is then deposited directly onto the steel substrate. Both visual and electrochemical analysis shows that this self-protective scheme leads to 60% corrosion inhibition in a neutral salt water solution.

The invention relates to a preparation method for 2-methyl-1,4-naphthoquinone. The preparation method utilizes phthalic acid diester and 3-cyanobutyrate to prepare 2-methyl-1,4-naphthoquinone throughcondensation, hydrolysis and decarboxylation and hydrogen cyanide removal under the action of strong alkali. The preparation method is easy in raw material obtaining, cheap in price and high in reaction atomic economy; and the 3-cyanobutyrate can be obtained through addition reaction of by-product hydrogen cyanide and 2-crotonate; and the preparation method is easy to operate, less in waste wateramount and green and environmentally friendly in technology, and therefore the discharging of waste water without heavy metals can be realized, and industrial production can be achieved.

The present invention relates to two novel and stable crystalline forms of atovaquone, to processes for their preparation and to pharmaceutical compositions comprising them. The present invention also provides crystalline particles of atovaquone having a specific surface area of from about 0.7 m²/g to about 4 m²/g, methods for the manufacture of said crystalline particles and pharmaceutical compositions comprising said crystalline particles. The present invention further provides an improved and commercially viable process for preparation of atovaquone substantially free of its undesired isomeric impurity, namely cis-2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone.

The invention discloses a practical synthesis method of compounds of 5-benzoyl-1, 4-naphthaquinone with a similar gossypol effect. The practical synthesis method comprises the steps that: a) malonic acid and acrolein take condensation reaction to obtain a compound of pentadienoic acid shown in the formula I; b) the compound shown in the formula I takes reaction with p-benzoquinone to obtain a compound of cis-5, 8-diketone-1,4,6,7,9,10-hexahydronaphthalene-beta-carboxylic acid shown in the formula II; c) the compound shown in the formula II is subjected to methylation to obtain a compound of 5,8-dimethoxy-1,4-dihydronaphthalene-1-carboxylic acid-methyl ester shown in the formula III; d) the compound shown in the formula III takes dehydro-aromatization reaction to obtain a compound of 5,8-dimethoxy naphthoate shown in the formula IV; e) the compound shown in the formula IV is hydrolyzed to obtain a compound of 5,8-dimethoxy naphthoyl naphthoic acid shown in the formula V; f) the compound shown in the formula V is subjected to chlorination to obtain a compound of 5,8-dimethoxy naphthoyl chloride shown in the formula VI; g) the compound shown in the formula VI and benzene are subjected to Friedel-Crafts acidylation to obtain a compound of 5-benzoyl-1,4-dimethoxy naphthalene shown in the formula VII; and h) the compound shown in the formula VII is oxidized to obtain a compound of 5-benzoyl-1,4-naphthoquinone shown in the formula VIII.

The invention relates to a preparation method of 2-acetoxyl-1,4-naphthoquinone, comprising the following steps of: (A) adding 2- hydroxyl-1,4-naphthoquinone into acetic anhydride; (B) adding concentrated sulfuric acid under the condition of water bath heating; (C) cooling a reactant at normal temperature; (D) adding a reacting solution into cold water and carrying out suction filtering to obtain a 2-acetoxyl-1,4-naphthoquinone crude product; and (E) re-crystalizing by using an organic solvent. The method is simple and feasible; and the obtained product used as a pesticide has broad application prospect.

The present invention describes a process for producing 2-methyl-1,4-naphthoquinone by oxidizing 2-methylnaphthalene with fresh hydrogen peroxide in the presence of glacial acetic acid without any mineral or transition metal catalyst.

The inventors have found that vitamin K3 and vitamin K5 which may be used in pharmaceuticals and foods or ACNQ, DHNA, or the like which can stimulate the growth of bifidobacteria can inhibit degranulation of basophil-like cells, exhibit a potent degranulation-inhibiting effect, and are useful anti-allergic agents or foods. The present invention provides an anti-allergic agent containing, as an active ingredient, one or more species selected from among 2-amino-3-carboxy-1,4-naphthoquinone, 1,4-dihydroxy-2-naphthoic acid, 1,4-naphthoquinone, 4-amino-2-methyl-1-naphthol, 2-methyl-1,4-naphthoquinone, 2-amino-3-chloro-1,4-naphthoquinone, and a salt thereof.

The invention discloses a catalyst. The catalyst comprises a carrier and an active component, wherein the carrier is a molecular sieve; the active component is a transition metal oxide modified by strong acid; the mass percentage content of the active component is 0.5%-50% based on the mass of the catalyst. The catalyst is used for preparing 1,4-naphthoquinone by liquid-phase oxidation of naphthalene. The invention also discloses a preparation method of the catalyst and application of the catalyst to preparation of 1,4-naphthoquinone by liquid-phase oxidation of naphthalene, the conversion rate of naphthalene and the selectivity of 1,4-naphthoquinone are effectively improved, the reaction conditions are mild, the operation is simple, and the catalyst is easy to prepare, pollution-free andrecyclable.

The invention discloses an atovaquone synthesis technology. The atovaquone synthesis technology comprises that in the presence of a silver nitrate catalyst, 2-ethoxy-1, 4-naphthoquinone and 4-(4-chlorophenyl)cyclohexyl-1-formic acid as raw materials are dissolved in an acetonitrile solvent, then the solution is added into a reactor and is heated along with stirring until reflux so that the reaction system undergoes a reaction, wherein in reflux, an ammonium persulfate aqueous solution is dropwisely added into the reaction system and the mole amount of the ammonium persulfate is 3-5 times that of 2-ethoxy-1, 4-naphthoquinone, after the reaction, the product is cooled and forms crystals, the crystals are filtered and are dissolved through trichloromethane, the solution is filtered, the filtrate is collected and is subjected to reduced pressure distillation so that trichloromethane is removed, and the solution is subjected to acetonitrile recrystallization so that atovaquone yellow acicular crystals are obtained. The atovaquone synthesis technology only needs one step, saves a synthesis cost, has a high yield and can produce high-purity atovaquone.