Method for preparing vitamin K3

Abstract

The invention provides a method for preparing vitamin K3, and relates to vitamin K3. The method for preparing vitamin K3 with the chemical name of 2-methyl-1,4-naphthoquinone includes the following steps: dissolving 2-methylnaphthalene into a hydrocarbon solvent; adding sodium dodecyl sulfate and chromium ion oxidation liquid for an oxidation reaction; after completion of the reaction, purifying the reaction solution to obtain vitamin K3 with the chemical name of 2-methyl-1,4-naphthoquinone. The method for preparing vitamin K3 with the chemical name of 2-methyl-1,4-naphthoquinone sodium bisulfate includes the following steps: dissolving 2-methyl-1,4-naphthoquinone into a mixed solvent of water and ethyl alcohol; then adding sodium bisulfite for a sulfonation reaction; after completion of the reaction, purifying the reaction solution to obtain vitamin K3 with the chemical name of 2-methyl-1,4-naphthoquinone sodium bisulfate. According to the invention, the method is high in reaction selectivity, mild in reaction conditions, short in operation steps, green and environment-friendly, and stable in process; the product purity is 97% or above, and the total yield is 79% or above.

Description

technical field [0001] The invention relates to vitamin K3, in particular to a preparation method of vitamin K3. Background technique [0002] Vitamin K3 is not only an important vitamin variety, but also an important intermediate for the synthesis of K-series vitamins, such as vitamin K1 (β-methyl-3-phytyl-l,4-naphthone), vitamin K2 (β- Methyl-3-difarnesyl-1,4-naphthoquinone), etc. 2-Methyl-1,4-naphthoquinone is the earliest vitamin K3 used by people. It has high activity and low price, but it has poor stability and is not easy to absorb. Then people developed a new type of easily absorbed vitamin K3 (sodium bisulfite menadione ). The function of vitamin K3 is to promote coagulation, and the level of prothrombin in the blood is directly related to the supply of vitamin K3. Animals deficient in vitamin K3 will significantly prolong the coagulation time, and in severe deficiencies, slight abrasions will cause bleeding and lead to death. In order to promote animal growth a...

AI Technical Summary

Problems solved by technology

2-Methyl-1,4-naphthoquinone is the earliest vitamin K3 used by people. It has high activity and low price, but it has poor stability and is not easy to absorb. Then people developed a new type of easily absorbed vitamin K3 (sodium bisulfite menadione )

Both of the above two routes need to adopt chromium oxidation system, but the current reaction system has the following disadvantages: poor selectivity of reaction, low yield, high reaction temperature, complicated post-treatment, etc.

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