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Phenolic compound and uses

A technology of compounds and drugs, applied in the field of medicine, can solve the problems of high toxicity and easy generation of drug resistance

Active Publication Date: 2011-11-30
广东德鑫制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although chemically synthesized drugs currently used clinically for tumor treatment play a very important role in tumor treatment, their side effects such as high toxicity and easy drug resistance limit their wide use.

Method used

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  • Phenolic compound and uses
  • Phenolic compound and uses
  • Phenolic compound and uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Take 20 kg of sunflower seeds that are dried and pulverized, use 70% ethanol (150 L) to reflux extract 3 times, each time for 3 hours, and combine the extracts. Ethanol was recovered under reduced pressure at 55°C to obtain 3.0 kg of concentrated extract (LC). Disperse 3.0kg of concentrated extract (LC) with 4.0L of water, and extract three times with equal volumes of petroleum ether, chloroform, ethyl acetate and n-butanol. The extracts were collected and concentrated to obtain 90.21 g of petroleum ether extract (LCP), 91.72 g of chloroform extract (LCC), 55.05 g of ethyl acetate extract (LCE) and 554.35 g of n-butanol extract (LCB).

[0066] Take 55.05 g of ethyl acetate extract (LCE), dissolve it with chloroform and methanol, and weigh 80 g of column chromatography silica gel (100-200 mesh) to mix the sample. Weigh 1200g of silica gel (200-300 mesh), dissolve the silica gel in chloroform and pack the column, and equilibrate the column with chloroform until the silic...

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Abstract

The invention belongs to the field of medical technology, and discloses a novel phenolic compound and uses. The physical and chemical constants and spectroscopic means are utilized to identify the chemical structure of the compound. The compound not only has good anti-aging effect, but also has good anti-tumor effect, has the advantages of high efficiency and low toxicity, and becomes a novel anti-tumor drug on the market.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a novel phenolic compound and its application. Background technique [0002] Malignant tumors are major diseases that endanger human health and life, and are increasingly threatening humans. In recent years, the incidence of tumors has increased significantly. Due to the reduction of infectious diseases, tumors and cardiovascular and cerebrovascular diseases have risen to the first and second place. However, if cardiovascular diseases and cerebrovascular diseases are separated, the incidence of tumors will be stable. rate and fatality rate. Based on this reality, governments, research institutions and pharmaceutical companies have long attached great importance to and invested heavily in tumor research and anti-tumor drug development, so that tumor treatment has been continuously developed. China is a world-recognized big country of natural medicine (Chinese herbal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/80A61K31/343A61P39/06A61P35/00A61P35/02
Inventor 何祥久滕慧梅曾小斌蒋晨光景运条黄有带
Owner 广东德鑫制药有限公司