Staphylokinase variant

A technology of staphylokinase and variants, applied in the fields of peptide/protein components, peptides, chemical instruments and methods, etc.
CN101848928BInactive Publication Date: 2013-07-17凝血基因公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
凝血基因公司
Publication Date
2013-07-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to an optimized thrombolytically or fibrinolytically active staphylokinase variant exhibiting low T-cell immunogenicity and reduced clearance by circulating antibodies that can be expressed at high levels.
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Description

field of invention

[0001] The present invention relates to optimized staphylokinase variants with thrombotic or fibrinolytic activity, low T-cell immunogenicity and low clearance by circulating antibodies expressing high levels. Background technique

[0002] Administration of fibrinolytic agents early in the onset of symptoms of myocardial ischemia can protect myocardial tissue, prevent secondary complications caused by myocardial infarction (congestive heart failure, arrhythmia, etc.), and most importantly - save life. The two most commonly used fibrinolytic agents are streptokinase (SK) and recombinant tissue plasminogen activator (rtPA). Despite the advantage of very low cost, SK is not as effective as rtPA (or mutants of rt-PA) in terms of arterial patency and 30-day mortality (the difference in mortality is maintained for at least two years) with concomitant hypotension , allergic reactions and neutralizing antibodies. Conversely, because rtPA is relatively expensive ...

Claims

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