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Particle for eliminating turbidity and treating arthralgia

A technology of Tongbi and granules, which is applied in the direction of plant raw materials, bone diseases, plant/algae/fungus/moss components, etc., can solve the problems of unsatisfactory curative effect and large side effects, and achieve anti-inflammatory and analgesic fast, quick effect, and drug effect strong effect

Active Publication Date: 2010-11-17
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN1895522 discloses a gout granule, which is composed of Smilax smilax, silkworm excrement, Clematis clematis, Fen , Zhonglou, Xu Changqing, Plantago and other raw materials, but the curative effect is not satisfactory, and the side effects are large

Method used

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  • Particle for eliminating turbidity and treating arthralgia
  • Particle for eliminating turbidity and treating arthralgia
  • Particle for eliminating turbidity and treating arthralgia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] [Example 1] Preparation of Quzhuo Tongbi Granules of the present invention

[0027] 1) Accurately weigh 600g Smilax smilax decoction pieces, put it in a 250mL standard ground three-neck bottle, add 100mL of 50% ethanol solution, heat at 80°C, solid-liquid ratio 1:20, heat and reflux for 3 hours, remove the leaching solution, and add 100mL of 50% ethanol solution, continue to leaching, a total of 3 times of leaching, evaporate the 3 times of leaching solution under reduced pressure, dry, and set aside;

[0028] 2) Grind coix seed through a 30-mesh sieve to make fine particles, accurately weigh 300g of coix seed granules, and extract at an extraction pressure of 33Mpa, an extraction temperature of 42°C, and CO 2 HL-1L / 50MPa-IIB type supercritical CO is used at a fluid flow rate of 10Kg / h 2 The fluid extraction equipment extracts coix seed oil for 3 hours, and then separates coix seed oil and CO 2 ,spare;

[0029] 3) Accurately weigh 200g of Radix Paeoniae Alba decoctio...

experiment example 1

[0035] 【Experimental Example 1】Effect on the Permeability of Mouse Peritoneal Capillaries

[0036] 50 NIH mice, half male and half male, were randomly divided into 5 groups, 10 mice in each group. After 7 days of continuous administration, 30 minutes after the last administration, each mouse was intravenously injected with 0.5% Evans blue normal saline solution 10ml / kg, and immediately intraperitoneally injected 0.2ml of 0.7% acetic acid. The peritoneal cavity was flushed with normal saline for 2 to 3 times, the peritoneal fluid was aspirated, and the optical density (OD) value was read with a 722-type grating spectrophotometer at 590 nm for colorimetry. The results were 1.328±0.423 in the normal saline group, 0.948±0.354 in the colchicine group (P<0.05), and 0.933±0.379 (P<0.05) and 0.713±0.315 (P<0.315) in the Quzhuo Tongbi granule high, middle and low dose groups respectively. 0.01), 0.913±0.423 (P<0.05). It shows that Quzhuo Tongbi granule has obvious inhibitory effect o...

experiment example 2

[0037] [Experimental Example 2] Effects on Adjuvant Arthritis Rats

[0038] Injection of Freund's complete adjuvant into the right hind toe of rats can cause acute inflammation and local tissue swelling. The anti-inflammatory effect of Quzhuo Tongbi Granules was observed by measuring the circumference changes of rat ankle joints before and after the experiment.

[0039] (1) Preparation of Freund's complete adjuvant

[0040]Prepare 100ml of liquid paraffin and lanolin (2:1), heat to 70°C, shake, and autoclave for 15 minutes to make Freund's incomplete adjuvant. Take 3 tubes of BCG (50mg / piece), add it to a mortar, grind while dripping Freund's incomplete adjuvant, grind for 2 hours, Freund's complete adjuvant turns milky white, take 1 drop into cold water, Freund's complete adjuvant does not spread , the preparation is successful.

[0041] (2) Establishment of adjuvant arthritis rat model

[0042] Take 40 rats, weigh them, and divide them into normal saline group, Quzhuo To...

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Abstract

The invention provides a medicine for treating gout, in particular relates to a particle for eliminating turbidity and treating arthralgia, which is prepared from rhizoma smilacis glabrae, coix seed, red peony root and caulis lonicerae. The particle is used for clinically treating acute gout, does not have side effects caused by treatment of Western medicines, has obvious effects on resisting inflammation and relieving pain, and has strong medical effect and lasting action. The short-term treatment effect of the particle is equivalent to the short-term treatment effect of Western medicine colchicine, and the long-term treatment effect of the particle is better than the long-term treatment effect of the colchicine.

Description

technical field [0001] The invention relates to a medicine for treating gout and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Gout is a refractory and recurrent metabolic rheumatic disease, which is closely related to a certain genetic background and excessive consumption of high-purine and high-protein foods. Since the 1990s, it has also become a common disease in China, especially in large cities and coastal areas, the incidence rate is about 0.77%, and there is an increasing trend. Acute arthritis is the first symptom. Although hyperuricemia is the biochemical basis, it has local inflammation as the main clinical manifestation, and because all urate-lowering drugs have no anti-inflammatory effect, it is useless for the treatment of inflammation, and acute arthritis often occurs clinically. Uric acid-lowering drugs for gout can aggravate or prolong the acute symptoms, or induce another acute attack, s...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61P19/06
Inventor 温成平范永升谢志军俞颖
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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