Sugar-lowering drug composition and application thereof

A composition and technology of hypoglycemic drugs, applied in the field of hypoglycemic drug compositions, can solve problems such as uncontrollable type 2 diabetes, reduce plasma homocysteine ​​elevation, protect endothelial cell function, and prevent diabetic complications Effect

Active Publication Date: 2010-12-01
深圳市奥萨制药有限公司 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to provide a hypoglycemic pharmaceutical composition and its use, which can effectively solve the defect that type 2 diabetes cannot be controlled by taking commonly us...

Method used

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  • Sugar-lowering drug composition and application thereof
  • Sugar-lowering drug composition and application thereof
  • Sugar-lowering drug composition and application thereof

Examples

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Effect test

no. 1 example

[0025] The hypoglycemic pharmaceutical composition includes 25 mg of vildagliptin, 2000 mg of metformin and 0.1 mg of folic acid.

[0026] Compound metformin and vildagliptin folic acid tablet (1000 pieces) preparation method:

[0027] Formula: Metformin 400g

[0028] Vildagliptin 5g

[0029] Folic Acid 800mg

[0030] Starch 100g

[0031] Microcrystalline Cellulose 100g

[0032] Sodium carboxymethyl starch 75g

[0033] Low-substituted hydroxypropyl cellulose 75g

[0034] Proper amount of povidone ethanol solution

[0035] Magnesium Stearate 0.5%

[0036] Preparation method: crush the auxiliary materials in the above formula through a 80-mesh sieve, and dry for later use. Take 400g of metformin, 5g of vildagliptin, and 800mg of folic acid and mix them uniformly according to the method of equal increase, and add starch, microcrystalline cellulose, sodium carboxymethyl starch and low-substituted hydroxypropyl cellulose accor...

no. 2 example

[0040] The hypoglycemic pharmaceutical composition includes 50 mg of vildagliptin, 1000 mg of metformin and 0.4 mg of folic acid.

[0041] Compound metformin and vildagliptin folic acid tablet (1000 pieces) preparation method in the present embodiment and compound metformin and vildagliptin folic acid tablet (1000 pieces) in the seventeenth embodiment of a kind of hypoglycemic pharmaceutical composition of the present invention The preparation method is the same, and the choice of carrier or excipient can be selected or the dose of carrier or excipient can be adjusted according to the common technical means in the art to realize the preparation of the pharmaceutical composition.

[0042] In this embodiment, metformin can also be any one of metformin hydrochloride, phenformin or buformin or any combination of the four; folic acid can also be any one or three of vitamin B12 or vitamin B6 any combination between.

no. 3 example

[0044] The hypoglycemic pharmaceutical composition includes 100 mg of vildagliptin, 500 mg of metformin and 7.5 mg of folic acid.

[0045] Compound metformin and vildagliptin folic acid tablet (1000 pieces) preparation method in the present embodiment and compound metformin and vildagliptin folic acid tablet (1000 pieces) in the seventeenth embodiment of a kind of hypoglycemic pharmaceutical composition of the present invention The preparation method is the same, and the choice of carrier or excipient can be selected or the dose of carrier or excipient can be adjusted according to the common technical means in the art to realize the preparation of the pharmaceutical composition.

[0046] In this embodiment, metformin can also be any one of metformin hydrochloride, phenformin or buformin or any combination of the four; folic acid can also be any one or three of vitamin B12 or vitamin B6 any combination between.

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Abstract

The invention relates to a sugar-lowering drug composition and application thereof. The composition comprises 1) medicinal dosage of vildagliptin, 2) medicinal dosage of any one or combination of thiazolidinedione sugar-lowering drugs or medicinal salt thereof, sulfonylurea sugar-lowering drugs or medicinal salt thereof or biguanide sugar-lowering drugs or medicinal salt thereof and 3) B vitamins. The invention relates to application of the sugar-lowering drug composition to preparing the drugs for treating and/or controlling diabetes or diabetic complications. The composition can effectively overcome the defect that type 2 diabetes can not be controlled by singly taking the commonly used sugar-lowering drugs or vildagliptin in the prior art and simultaneously addition of the B vitamins is conductive to enhancing the treatment effect of the drug, effectively controlling the blood sugar, protecting the endothelial cell functions in a synergic manner, slowing rising of plasma homocysteine of the diabetes patients, especially the diabetes patients associated with chronic complications and reducing the diabetic complications.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a hypoglycemic pharmaceutical composition with vildagliptin, other hypoglycemic drugs and B vitamins as main active ingredients and its application. Background technique [0002] Diabetes mellitus (Diabetes Inellitus) is a metabolic disease of multiple etiologies, characterized by chronic hyperglycemia, accompanied by disorders of sugar, fat and protein metabolism caused by defects in insulin secretion and / or action. Diabetes can occur at any age. As the course of the disease prolongs, it is easy to cause histopathological damage such as systemic nerve, microvascular and macrovascular lesions, and can lead to chronic and progressive lesions of the heart, brain, kidney, nerves and eyes and other tissues and organs, resulting in Blindness, lower extremity gangrene, uremia, stroke or myocardial infarction will eventually occur, and even life-threatening. With the improvement of livin...

Claims

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Application Information

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IPC IPC(8): A61K31/40A61K31/155A61K45/00A61K31/519A61K31/714A61K31/4415A61K31/4439A61K31/64A61P3/10A61P9/00A61P13/12A61P25/00A61P27/02A61P17/00
Inventor 靳晴于多陈光亮徐希平
Owner 深圳市奥萨制药有限公司
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