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Preparation method of lithocarpus litseifolius total flavone

A technology of total flavonoids and wood ginger, which is applied in the field of preparation of plant medicines and health products, can solve problems such as unacceptable, and achieve the effect of convenient source, low toxicity and high extraction rate

Inactive Publication Date: 2010-12-08
GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Diabetic patients are unacceptable to long-term injections

Method used

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  • Preparation method of lithocarpus litseifolius total flavone
  • Preparation method of lithocarpus litseifolius total flavone
  • Preparation method of lithocarpus litseifolius total flavone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0136]Take 1500g of young leaf powder of Alpinia japonicus, add 10 times the amount of 70% (volume concentration, the same below) ethanol to reflux for extraction three times, each time for 2 hours, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure until it has no alcohol smell, add water Dilute to 15000mL, stir well, stand for 24 hours, filter, and the filtrate is used as the sample solution; respectively measure 5100mL of polyamide resin (80-100 mesh) that has been processed, and wet-pack the column, and the amount of phlorizin on the column ( The ratio of mg) to resin volume (mL) is 23:1, and the sample solution is adsorbed at a flow rate of 1BV / h, eluted with 2BV of water, and the water eluate is discarded, and then used with 20% ethanol at a flow rate of 2BV / h Flow rate elution, collect 20BV of eluate, eluent decompression recovery ethanol, concentrated, vacuum-dried to obtain the hypoglycemic extract of the present invention, m...

Embodiment 2

[0139] Take 100g of dry leaf powder of Koji japonica, add 10 times the amount of 70% ethanol to reflux and extract three times, each time for 2 hours, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure until it has no alcohol smell, add water to dilute to 1000mL, stir well, Stand for 24 hours, filter, and the filtrate is used as the sample solution; measure 340 mL of the treated polyamide resin (80-100 mesh) respectively, and wet-pack the column. ) ratio of 23:1, the sample solution was adsorbed at a flow rate of 1BV / h, eluted with 2BV of water, discarded the water eluent, eluted with 20% ethanol at a flow rate of 2BV / h, and collected 20BV of The eluent, ethanol is recovered under reduced pressure from the eluent, concentrated, and vacuum-dried to obtain the hypoglycemic extract of the present invention-total flavonoids of Leucophyllum japonica. As a result of the determination, the purity of the total flavonoids was 85.13%, and the ...

Embodiment 3

[0141] Take 300g of fine powder of tender leaves of Alpinia japonicus, add 10 times the amount of 70% ethanol to reflux and extract three times, each time for 2 hours, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure until it has no alcohol smell, add water to dilute to 3000mL, stir well, Stand for 24 hours, filter, and the filtrate is used as the sample solution; measure 1050 mL of the treated polyamide resin (80-100 mesh) respectively, and wet-pack the column, the amount of phlorizin on the column (mg) and the resin volume (mL ) ratio of 23:1, the sample solution was adsorbed at a flow rate of 1BV / h, eluted with 2BV of water, discarded the water eluent, eluted with 20% ethanol at a flow rate of 2BV / h, and collected 20BV of The eluent, ethanol is recovered under reduced pressure from the eluent, concentrated, and vacuum-dried to obtain the hypoglycemic extract of the present invention-total flavonoids of Leucophyllum japonica. As ...

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Abstract

The invention discloses lithocarpus litseifolius total flavone extracted by using plant lithocarpus litseifolius as a raw material to develop a new hypoglycemic medicament, and provides a method for preparing the lithocarpus litseifolius total flavone. The purity of the lithocarpus litseifolius total flavone prepared by the method can reach over 80 percent, the phloridzin content reaches over 65 percent, the process is simple and has low energy consumption, and the technological condition is reasonable, stable and feasible. A hypoglycemic capsule developed by using the lithocarpus litseifolius total flavone can provide a convenient, acceptant and long-term taking oral hypoglycemic preparation for diabetics.

Description

technical field [0001] The invention relates to the preparation of medicines, more specifically the preparation methods of plant medicines and health care products for lowering blood sugar. Background technique [0002] Fagaceae is Lithocarpus litseifolius Chun., which is mainly distributed in the dense forests of Baise, Lingyun, Pingguo, Napo, Longlin, Daming Mountain and Hechi in Guangxi, China, and is rich in resources. The main components of Mujiang Yeke are flavonoids, with a content of up to 12.6%, mainly including phlorizin, trilobatin, and 3-hydroxyphloridin. Pharmacological studies have found that phlorizin and its isomer trilobatin have a pharmacokinetic synergistic effect on the regulation of glucose metabolism. Phlorizin can reverse insulin resistance and make insulin resistant rats glucose tolerance and insulin sensitivity Sexual recovery to normal, correcting the sensitivity of glucagon to glucose in hyperglycemic dogs, inhibiting the intestinal absorption of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P3/10A23L1/29A61K127/00A23L33/00
Inventor 韦宝伟李茂蒋珍藕曾宪彪邱宏聪
Owner GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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