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Fat emulsion pre-emulsifying concentrated solution for teniposide intravenous injection and preparation method thereof

A teniposide and pre-emulsification technology, which is applied in the direction of emulsion delivery, oil/fat/wax non-active ingredients, medical preparations of non-active ingredients, etc., can solve the problems of strong side effects, etc., to extend the validity period and improve the preparation process Simple, effective improvement for severe allergies

Inactive Publication Date: 2012-08-29
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But as mentioned earlier, both Cremophor EL and Tween 80 have strong side effects

Method used

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  • Fat emulsion pre-emulsifying concentrated solution for teniposide intravenous injection and preparation method thereof
  • Fat emulsion pre-emulsifying concentrated solution for teniposide intravenous injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1, prescription screening of teniposide injection

[0047] Prepare the solution as above, and observe the result after 8 hours. The prescription composition and screening results of teniposide are shown in Table 1.

[0048] Table 1. Prescription composition and screening results of teniposide

[0049]

[0050]

Embodiment 2

[0052] prescription:

[0053] Teniposide 0.05g

[0054] Lecithin 3.0g

[0055] soybean oil 0.2g

[0056] N,N-Dimethylacetamide 0.3g

[0057] Absolute ethanol 5g

[0058] Preparation:

[0059] Add 0.05g of teniposide into 0.3g of N,N-dimethylacetamide, after it is completely dissolved, add 3g of lecithin, 0.2g of soybean oil and 5g of absolute ethanol, stir to make them evenly mixed Forms a clear, clear pre-emulsion concentrate.

Embodiment 3

[0061] prescription:

[0062] Teniposide 0.05g

[0063] Lecithin 3.0g

[0064] soybean oil 0.2g

[0065] N,N-Dimethylacetamide 0.3g

[0066] Absolute ethanol 5g

[0067] Preparation:

[0068] Teniposide 0.05g is added to the mixed solution of 0.3g of N,N-dimethylacetamide and 0.2g of soybean oil, after completely dissolving, add lecithin 3g and dehydrated alcohol 5g, stir to make They are mixed well to form a clear and clear pre-emulsion concentrate.

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Abstract

The invention belongs to the field of medicinal preparations and discloses fat emulsion pre-emulsifying concentrated solution for teniposide intravenous injection and a preparation method thereof. The fat emulsion pre-emulsifying concentrated solution for teniposide intravenous injection comprises the following components in percentage by weight: 0.01 to 10 percent of teniposide, 0 to 20 percent of oil phase, 10 to 80 percent of phospholipids and 10 to 99 percent of organic solvent for injection. The preparation method comprises the following steps of: dissolving the active ingredient, namelythe teniposide, in the organic solvent or the oil phase or the mixture of the organic solvent and the oil phase, adding the other components in the formula into the mixture, and after stirring to uniformly mix the components, obtaining the transparent and clear pre-emulsifying concentrated solution.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a formula of fat emulsion pre-emulsified concentrate for intravenous injection of teniposide and a preparation method thereof. Background technique: [0002] Teniposide (Teniposide, Vumon, VM-26) aliases: Wittmann, Vumon 26, thiamin glucoside, Banglai, podophylloside. It is a semi-synthetic derivative of podophyllotoxin, which belongs to the antitumor drug of plant origin. It is a cycle-specific cytotoxic drug that inhibits DNA topoisomerase II, causing double-strand or single-strand damage to stop cell mitosis at late S or G 2 In the early stage, it hinders tumor cell division and inhibits tumor growth. Teniposide has a remarkable curative effect, and its biological activity is 5 to 10 times that of the same type of drug etoposide, and clinical data show that teniposide has few side effects, low toxicity, and has no obvious effect on liver and kidney func...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/7048A61K47/24A61K47/44A61K47/14A61K47/18A61P35/00
Inventor 张强代文兵王坚成张烜
Owner PEKING UNIV
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