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Human basic fibroblast growth factor eye drops and preparation method thereof

A technology of fibroblasts and growth factors, applied in the application of trauma, the field of eye drops of human basic fibroblast growth factors, can solve the problems of poor treatment effect, waste of active ingredients, blocking the line of sight, etc., and achieve shortening Effects on healing time, repairing wounds, avoiding immune response

Active Publication Date: 2011-01-19
朗肽生物制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the prior art, there are few reports on the proliferation-promoting effect of human basic fibroblast growth factor on the multiple non-fibroblasts that account for the majority in the conjunctiva and cornea, and the effective dose of the pharmaceutical preparation is also unclear, and even more A technical effect of lower doses or even better overall efficacy than higher doses could not be expected
[0004] In addition, the current eye drop preparations for treating eye diseases cannot stay in the eyelids for a long time, so the treatment effect is not good, and the active ingredients are seriously wasted.
Although it can stay in the eyelids for a long time by being formulated into eye ointment preparations, it is limited to use when sleeping because it is a semi-solid object that blocks the line of sight, which brings a lot of inconvenience to patients and limits its popularization and use.

Method used

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  • Human basic fibroblast growth factor eye drops and preparation method thereof
  • Human basic fibroblast growth factor eye drops and preparation method thereof
  • Human basic fibroblast growth factor eye drops and preparation method thereof

Examples

Experimental program
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preparation Embodiment 1

[0032]Prepare 100ml of eye drops: Dissolve 1g of sodium hyaluronate in 40ml of water for injection and set aside; take another 50ml of water for injection, add 5g of mannitol and 0.9g of sodium chloride, add 100μg of human basic fibroblasts after completely dissolving Growth factors, then add the sodium hyaluronate solution prepared in advance, mix well, add water for injection to the required volume and add sodium hydroxide solution at the same time to make the pH 7.0, use a 0.2-0.5 μm microporous membrane Filter and sterilize, and pack the filtrate into eye drop plastic bottles to make the eye drop finished product of the present invention.

preparation Embodiment 2

[0034] Prepare 100ml eye drops: Dissolve 1g of sodium hyaluronate completely in 40ml of water for injection for later use; take another 50ml of water for injection, add 0.3g of ethyl p-hydroxybenzoate, 5g of mannitol, 1g of human serum albumin, 0.9g of chlorine Sodium chloride, after completely dissolving, add 100 μg of human basic fibroblast growth factor, then add the sodium hyaluronate solution prepared in advance, mix well, add water for injection to the required volume and add sodium hydroxide solution at the same time to make When the pH is 7.0, it is sterilized by filtration with a microporous membrane of 0.2-0.5 μm, and the filtrate is dispensed into eye drop plastic bottles to prepare the finished eye drop product of the present invention.

preparation Embodiment 3

[0036] Prepare 100ml eye drops: Dissolve 1g sodium hyaluronate completely in 40ml water for injection for later use; take another 50ml water for injection, add 0.3g ethyl p-hydroxybenzoate, 0.01g heparin sodium, 5g mannitol, 1g human serum white Protein, 0.9g sodium chloride, after completely dissolved, add 100μg human basic fibroblast growth factor, then add the sodium hyaluronate solution prepared in advance, mix well, add water for injection to the required volume and add The pH of the sodium hydroxide solution is 7.0, and it is sterilized by filtration with a microporous membrane of 0.2-0.5 μm, and the filtrate is dispensed into eye drop plastic bottles to prepare the finished eye drop product of the present invention.

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Abstract

The invention belongs to the biological product field, and provides eye drops containing human basic fibroblast growth factors (hbFGF), which is characterized by containing the hbFGFs, sodium hyaluronate, mannitol, albumin, heparin sodium, sodium chloride and the like. In addition, the invention further provides a method for preparing the eye drops and an application of the eye drops in assisting in treating wounds of conjunctiva and cornea.

Description

technical field [0001] The invention belongs to the field of biological products, in particular, the invention relates to eye drops of human basic fibroblast growth factor, its preparation method and its application in auxiliary treatment of conjunctiva and cornea wounds. Background technique [0002] The conjunctival and corneal wounds on the ocular surface often last for more than 1 week without healing, forming persistent conjunctival and corneal defects on the ocular surface. Ocular surface trauma has a variety of causes, such as corneal trauma, surgery involving the cornea, alkaline chemical damage to the cornea or conjunctiva, and toxic reactions from eye drops. If timely and effective treatment cannot be obtained, it can often lead to corneal ulcer or dissolution, or even corneal perforation, which can affect visual function in severe cases. In the traditional wound treatment of the conjunctiva and cornea on the ocular surface, measures such as anti-infection, enhanc...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K47/42A61P27/02A61K31/7036
Inventor 黄启斌李校堃黄志峰张元方黄燕红吴玲
Owner 朗肽生物制药股份有限公司
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